• To reduce the risk of cardiovascular death and hospitalization in adults with heart failure.

Sacubitril is a prodrug metabolized to the active metabolite, which inhibits neprilysin, thereby increasing levels of peptides (such as natriuretic peptides). It works to help control blood volume. Valsartan is an angiotensin receptor blocker that selectively blocks the AT1 receptor and inhibits angiotensin-II-dependent aldosterone release. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Sacurise 50mg Tablet and reduce its effectiveness by causing undesirable side effects. Inform your physician if you are taking medicines that contain aliskiren. 

• Do not store above 25°C).
• Store in the original package to protect from light.
• keep the injection away from the reach of children and pets.

Always take this medicine exactly as your doctor or pharmacist has told you. Your physician will decide the dose and duration of the treatment based on your disease severity and other factors. Swallow the tablets with a glass of water. You can take Sacurise 50mg Tablet with or without food. Do not crush, chew, or split the tablets. 

ide effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

• Low blood pressure
• Increased potassium levels
• Dizziness

Serious

• Kidney damage
• Angioedema (swelling of the face, lips, tongue and throat, and difficulties in breathing)

It is advisable to take your medicine at the same time each day. However, if you forget to take a dose, you should take the next one at the scheduled time. Do not take a double dose to make up for a forgotten tablet. Inform your physician if you have kidney problems before initiating the therapy. This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

1. Novartis Pharmaceuticals UK Ltd, Electronic Medicines Compendium(EMC), [Revised on June 2023 [Accessed on 14th June 2023], https://www.medicines.org.uk/emc/files/pil.5074.pdf
2. Novartis, US Food and Drug Administration, [Revised on February 2021] [Accessed on 14th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
3. KD Tripathi, Cardiac Glycosides and Drugs for Heart Failure, Essentials of Medical Pharmacology, 8th Edition, 2019, 556-569.
4. Ian A. Reid, Vasoactive Peptides, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 300-320.