Quick Summary
Samluta 40mg Capsule
Last updated on 11 Jun 2026 | 06:52 AM (IST)
₹4454
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₹4454
MRP: ₹10,781.24
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Introduction to Samluta 40mg Capsule
Samluta 40mg Capsule contains Enzalutamide, a targeted therapy classified as an androgen receptor inhibitor. It is commonly prescribed for adults with advanced prostate cancer, especially when the disease no longer responds to surgical or hormonal interventions. This oral anticancer medication works by blocking the effects of male hormones (androgens) that fuel the growth of prostate cancer cells.
Patients on Samluta 40mg may need regular monitoring through PSA (Prostate-Specific Antigen) blood tests to assess disease progression and treatment response. Liver function tests and complete blood counts are also recommended periodically to track safety during long-term use.
This medication may lower the threshold for seizures and should be used with caution in individuals with a history of neurological conditions. Avoid grapefruit or grapefruit juice, as it may raise drug levels in the blood. Because of its potential to cause infertility and fetal harm, effective contraception is essential for both men and women during and for at least three months after stopping the treatment.
Uses
- Used in the treatment of advanced prostate cancer that has not responded to other therapies.
How It Works
Samluta 40mg Capsule works by blocking the androgen receptors on prostate cancer cells. These receptors normally allow the hormone dihydrotestosterone (DHT) to stimulate cancer growth. By preventing DHT from binding, the drug disrupts cancer cell signaling, slows disease progression, and reduces tumor proliferation.
Interaction of Samluta 40mg Capsule with other drugs
Tell your doctor about any prescription drugs, herbal supplements, or over-the-counter medications you take regularly. Samluta Capsule may interact with anticoagulants, anticonvulsants, or drugs affecting liver enzymes. Some interactions may reduce treatment effectiveness or increase the risk of side effects.
Storage Information
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Store in a cool, dry place between 20°C to 25°C.
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Keep away from children and pets.
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Do not remove capsules from the original packaging until use.
How to Take it
Take Samluta Capsule exactly as prescribed by your doctor. The standard dose is 160mg once daily, which may be taken with or without food. Swallow the capsules whole with water do not crush or open them. If you miss a dose, take it at the next scheduled time. Do not double up to compensate for a missed dose.
Safety Advice for Samluta 40mg Capsule
Breast Feeding
Samluta is not intended for use in women, especially during lactation. Speak with your doctor if accidental exposure occurs.
Alcohol
The interaction of Samluta 40mg Capsule with alcohol is not well studied. Avoid alcohol unless your doctor says it is safe.
Liver
Patients with liver conditions should be closely monitored while taking Samluta. Liver function tests are advised before and during therapy.
Lungs
The safety of Samluta in patients with lung diseases has not been established. Report any existing respiratory concerns to your physician.
Driving
This medication may cause dizziness, fatigue, or seizures in rare cases. Avoid driving or operating machinery if these symptoms occur.
Pregnancy
Though not used by women, exposure during pregnancy can harm the unborn baby. Men with partners of childbearing age must use contraception during and for 3 months after the last dose.
Side Effects
Like most cancer treatments, Samluta 40mg may cause some side effects. While not everyone experiences them, it’s important to be aware:
Common Side Effects:
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Fatigue or tiredness
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Back pain or joint stiffness
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Headache or difficulty concentrating
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High blood pressure
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Constipation or diarrhea
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Loss of appetite
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Dry skin or skin rashes
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Breast swelling in men (gynecomastia)
Serious Side Effects:
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Seizures
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Allergic reactions
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Posterior Reversible Encephalopathy Syndrome (PRES)
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Falls or bone fractures
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Heart conditions or palpitations
Seek immediate medical help if you experience any signs of severe side effects.
Quick Tips
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Take the medicine at the same time daily to maintain consistent drug levels in your body.
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Avoid grapefruit juice, which may dangerously increase enzalutamide concentration in the bloodstream.
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Use skin moisturizers regularly, as Samluta 40mg may cause dryness and flaking.
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Stay hydrated and eat a balanced diet to manage fatigue and improve treatment tolerance.
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Inform all healthcare providers about your treatment if you’re scheduled for surgery or dental work.
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Do not stop the medicine abruptly without your oncologist’s advice—even if you feel better.
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Contraception is crucial: Men must use barrier protection throughout treatment and for 3 months afterward.
FAQs about Samluta 40mg Capsule
Q1.
What is Samluta 40mg Capsule used for?
Samluta is prescribed to treat men with advanced prostate cancer, particularly when the disease no longer responds to surgical or hormonal therapy. It’s part of hormone-based treatment plans
Q2.
Can Samluta replace chemotherapy?
Samluta is not chemotherapy. Instead, it's a targeted hormone therapy (androgen receptor inhibitor) used with castration or other hormone treatments. It may be used before or after chemotherapy, depending on the stage and patient condition .
Q3.
What are the common side effects from Samluta 40mg Capsule?
Common experiences may include fatigue, back or joint pain, diarrhea, high blood pressure, headache, hot flushes, and swelling in hands or feet
Q4.
What tests are needed during treatment?
Your doctor will regularly check PSA levels (to monitor cancer response), liver function tests, and blood counts. Blood pressure checks are also common during treatment monitoring.
Q5.
Which serious side effects require immediate attention?
Seek medical help if you encounter seizures, chest pain, significant swelling, fractures, or symptoms of PRES. Though rare, these could indicate severe complications.
Fact Box of Samluta 40mg Capsule
Molecule name: Enzalutamide
| Therapeutic class: Antineoplastics |
Pharmacological class: Androgen receptor inhibitors | Indications: 1.Advanced prostate cancer |
References
- Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
- Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
- Martín LázaroQuintela et al., Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021],https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
- Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.
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Author Details
Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 11 Jun 2026 | 06:52 AM (IST)
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