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Selepeg 400mcg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Substitutes
Zexipag 400mcg Tablet
CIPLA LTD
₹ 119.30/tablet
14% cheaper
Introduction to Selepeg 400mcg Tablet
Selepeg 400mcg Tablet is a pulmonary vasodilator medication that belongs to a class of drugs called prostacyclin receptor agonists containing the active ingredient Selexipag. It is used to treat pulmonary arterial hypertension (PAH) to improve exercise capacity and delay disease progression. Pulmonary arterial hypertension is a serious and rare medical condition caused by high blood pressure in the arteries that supply the lungs. It primarily affects the small blood vessels (arteries) in the lungs, leading to their narrowing and increased resistance to blood flow.
This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. It is also contraindicated if you have certain heart conditions such as severe coronary heart disease, unstable angina, recent heart attack, decompensated cardiac failure, severe irregular heartbeat, or certain heart valve defects. Also, if you have had a stroke within the last three months or any other event that reduces blood supply to the brain or are taking gemfibrozil (a medication used to lower lipid levels), this drug should not be taken.
If you have issues with your thyroid gland, it is necessary to inform your physician. Thyroid problems can impact the treatment plan, and your doctor will consider the potential effects of this drug on your condition. This drug is contraindicated during pregnancy because it can harm a developing fetus, and breastfeeding is not recommended in patients taking Selepeg 400mcg Tablet because it is unknown whether the medicine passes into the breast milk and harms your baby. This drug is metabolized and excreted by the kidneys, so if you have severe kidney problems or are undergoing dialysis, your doctor needs to determine the appropriate dosage or prescribe an alternative medicine if necessary.
Uses of Selepeg 400mcg Tablet
- Treatment of pulmonary arterial hypertension (PAH)
Therapeutic Effects of Selepeg 400mcg Tablet
Selexipag in Selepeg 400mcg Tablet works by activating the prostacyclin receptors in the blood vessels of the lungs. This activation leads to the relaxation and widening of the blood vessels, reducing the elevated blood pressure in the pulmonary arteries. By dilating the blood vessels, this drug improves blood flow and reduces the workload on the heart.
Interaction of Selepeg 400mcg Tablet with other drugs
Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Selepeg 400mcg Tablet and reduce effectiveness by causing undesirable side effects.
More Information about Selepeg 400mcg Tablet
- Store Selepeg 400mcg Tablet below (25°C).
- Protect from light and moisture.
How to consume Selepeg 400mcg Tablet
Take the Selepeg 400mcg Tablet as advised by your physician. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Safety Advice for Selepeg 400mcg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking Selepeg 400mcg Tablet because it is unknown whether the medicine passes into the breast milk and harms your baby.
Alcohol
It is unknown whether consuming alcohol while taking a Selepeg 400mcg Tablet is safe. Please speak with your physician.
Liver
Inform your doctor if you have liver disease because the Selepeg 400mcg Tablet should be used cautiously with a liver condition.
Lungs
Selepeg 400mcg Tablet is safe for patients with lung problems. Consult your doctor for more advice.
Driving
Some side effects of Selepeg 400mcg Tablet may cause headache and low blood pressure. It impairs your ability to drive or operate machinery safely. It is unsafe to consume this drug.
Pregnancy
Selepeg 400mcg Tablet is not recommended during pregnancy or if there is a possibility of becoming pregnant. It is advised for women to use appropriate contraceptive measures to prevent pregnancy while using this medication.
Side Effects of Selepeg 400mcg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Headache
- Diarrhea
- Reddening of face
- Vomiting, nausea
- Pain in the jaws, muscles, legs, or joints
- Stuffy nose
Common
- Weight loss
- Stomach pain
- Rashes
- Hyperthyroidism
- Reduced appetite
Word of Advice
Since this medication aims to reduce joint pain, swelling, and stiffness, it may take several weeks or months to experience the full benefits of Selepeg 400mcg Tablet, so be patient and continue taking it as directed.
FAQs about Selepeg 400mcg Tablet
Q1.
What is the actual mechanism of Selepeg 400mcg Tablet?
Selepeg 400mcg Tablet works by activating the prostacyclin receptors in the blood vessels of the lungs. This activation helps to widen and relax the blood vessels, reducing the elevated blood pressure in the pulmonary arteries and improving blood flow.
Q2.
What are the common side effects of Selepeg 400mcg Tablet?
The common side effects of Selepeg 400mcg Tablet include headache, jaw pain, nausea, diarrhea, muscle pain, flushing, joint pain, and pain in the extremities. These side effects are usually mild to moderate in severity. However, reporting any side effects to your physician for evaluation is important.
Q3.
Are there any serious side effects associated with Selepeg 400mcg Tablet?
Yes, some serious side effects can occur with Selepeg 400mcg Tablet. These include liver problems (such as elevated liver enzymes), fluid retention, low platelet count (thrombocytopenia), and pulmonary veno-occlusive disease (a rare condition where the blood vessels in the lungs become narrowed). It's essential to seek immediate medical attention if you experience symptoms such as severe dizziness, fainting, significant weight gain, or yellowing of the skin/eyes.
Q4.
Are there any medications that should not be taken with Selepeg 400mcg Tablet?
Yes, some medications can interact with Selepeg 400mcg Tablet. One example is gemfibrozil, a medication used to lower lipid levels in the blood. Gemfibrozil can increase the exposure to this drug and should not be taken concomitantly. It's important to inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, that you are taking to avoid potential interactions.
Q5.
What is the dosage strength of Selepeg 400mcg Tablet?
Selepeg 400mcg Tablet is available in tablet forms under the strength of 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg
Fact Box of Selepeg 400mcg Tablet
Molecule name: Selexipag
| Therapeutic class: Pulmonary vasodilator |
Pharmacological class: Prostacyclin receptor agonists | Indications: Treatment of pulmonary arterial hypertension (PAH) |
References
- Janssen-Cilag Limited, Electronic medicines compendium (EMC), [Revised on June 2022] [ Accessed on 18th July 2023], https://www.medicines.org.uk/emc/files/pil.2163.pdf
- Actelion Pharmaceutical US, US Food and Drug Administration, [Revised on Dec 2017] [ Accessed on 18th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207947s005lbl.pdf
- Olivier Sitbon et al.; Selexipag for the Treatment of Pulmonary Arterial Hypertension; The New England Journal of Medicine; Published on Dec 2015; Accessed on 18/07/2023; https://pubmed.ncbi.nlm.nih.gov/26699168/
Disclaimer
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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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