Silochet D Tablets are a combination of two active ingredients called Dutasteride and Silodosin, which help to relieve the symptoms caused by an enlarged prostate in adults. It is mainly used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride and Silodosim belong to the family called 5-Alpha reductase inhibitors and Alpha-1 blockers. Taking this medication can help to reduce the problems like difficulty in urination, frequent urination, and other related symptoms. This medicine is specifically for men and should not be taken by women or children.

Silochet D Tablets should not be consumed if you are allergic to Dutasteride, Silodosin, or any of the ingredients in the medication. Do not consume this medicine if you have severe liver or kidney problems. Notify your doctor if you have heart disease or if you notice breast lumps or nipple discharge. It is advised to use contraceptives to avoid the transfer of semen. Inform your doctor if you are taking this medicine during a PSA test because it can affect PSA blood tests for detecting prostate cancer.

• Treatment of benign prostatic hyperplasia

Silochet D Tablets capsule blocks the conversion of the hormone testosterone to dihydrotestosterone by blocking an enzyme called 5α-reductase in the genital region. This reduces the concentration of dihydrotestosterone in the blood and increases the urine flow rate.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Silochet D Tablets and can cause undesirable side effects.

• Keep out of sight and reach of pets and children.
• Do not freeze the medicine.
• Do not store above 30°C.
• Always check the expiry date before consuming it.

Take the Silochet D Tablets as your physician advises. Usually, the tablets will be taken with or without food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Serious

• Skin rash
• Hives
• Swelling of face, eyelids, lips, arms, or legs

Common

• Low sperm count and movement
• Low sex drive
• Impotence
• Enlarged or painful breasts

Before prescribing Silochet D Tablets, your healthcare provider will assess for prostate problems, including cancer. Inform their doctor if you have plans for cataract surgery and about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.

1. Kazuhisa Hagiwara et al., Efficacy and Safety of Silodosin and Dutasteride Combination Therapy in Acute Urinary Retention due to Benign Prostatic Hyperplasia: A Single-Arm Prospective Study, BioMed Research International, 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852328/pdf/BMRI2016-4975851.pdf
2. J. Goddard, A.N. Turner, Kidney and Urinary Tract Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 461-523.
3. Peter J. Snyder, Androgens and the Male Reproductive Tract, Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 833-843.
4. Rivopharm UK Ltd, Electronic Medicines Compendium (EMC), [Revised on March 2017] [Accessed on 23 June 2023], *Microsoft Word - uk-pl-clean (medicines.org.uk)
5. Dailymed, [Accessed on 23 June 2023], DailyMed - SILODOSIN capsule (nih.gov)