Quick Summary
Simponi 50mg Injection
Last updated on 26 Sep 2026 | 08:43 AM (IST)
₹22725
MRP: ₹26578.13
(You Save ₹3853.13)
1 PREFILLED SYRINGE(s) OF 0.5ML
Simponi 50mg Injection is a prescription medicine used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. It contains golimumab, a tumour necrosis factor (TNF) inhibitor that works by blocking a protein responsible for inflammation, helping to reduce symptoms, improve joint function, and prevent disease progression. Simponi 50mg Injection should be used under strict medical supervision as part of a comprehensive treatment plan.
Simponi 50mg Injection
Salt Composition
GOLIMUMABMarketer
JOHNSON & JOHNSON PVT LTD
Prepaid Only. Non-Returnable.
15% OFF
₹22725
MRP: ₹26,578.13
Inclusive of all taxes
15% Off
Salt Composition
GOLIMUMABMarketer
JOHNSON & JOHNSON PVT LTD
Prepaid Only. Non-Returnable.
Dispatch: Today
Care delivered without the wait. Your order is prioritized for rapid dispatch to ensure it reaches your doorstep on time.
Substitutes
Golimurel 50mg Injection
RELIANCE LIFE S...
₹ 19061.00/injection
16% cheaper
Introduction
Simponi 50mg injection contains an active component as Golimumab. It is a monoclonal antibody drug used to treat autoimmune diseases, particularly certain inflammatory conditions. It works by targeting and inhibiting a certain protein, which plays a role in causing inflammation in the body. Simponi for rheumatoid arthritis in adults is approved, often in combination with other disease-modifying antirheumatic drugs (DMARDs). Simponi for psoriatic arthritis treatment, an autoimmune condition affecting joints and skin. It can treat ankylosing spondylitis, a type of arthritis primarily affecting the spine and sacroiliac joints. One of the advantages of this medication is that it offers relatively long dosing intervals compared to other biological medications.
Simponi 50mg injection should not be used in patients with known hypersensitivity or severe allergic reactions to the drug. Allergic reactions can be life-threatening and may include symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing. This medication can suppress the immune system, making patients more susceptible to infections. Individuals with active infections should start treatment once the infection is resolved. Individuals with a history of hepatitis B infection should require close monitoring before starting treatment, as the virus can reactivate during treatment. Patients with a history of heart failure or other significant cardiovascular conditions require close monitoring. Simponi 50mg injection's safety and efficacy in pediatric patients may differ from its use in adults. Older individuals may be at a higher risk of osteoporosis and fractures. The impact of this medication on bone health should be monitored, especially if the patient is already at risk. Patients with kidney impairment may require a Simponi dosage schedule, as the clearance of these medications is affected by impaired kidney function. Simponi price India varies by retailer and location. Simponi alternatives biosimilars include brands like Zessly, Simlandi, and Inflectra, but should only be used under a doctor’s prescription.
Uses
Simponi injection uses in the treatment of the following:
- Rheumatoid arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Axial spondyloarthritis
- Ulcerative colitis
- Juvenile idiopathic arthritis
How Simponi 50mg Injection Works
Golimumab in Simponi 50mg injection exerts its therapeutic effect through its role as a tumor necrosis factor-alpha (TNF-alpha) inhibitor. TNF-alpha is a cytokine involved in promoting inflammation and immune responses. This medication binds to soluble and transmembrane forms of TNF-alpha, preventing their interaction with cell surface receptors and dampening the downstream inflammatory signalling pathways. By inhibiting TNF-alpha, this medication helps reduce inflammation, alleviate symptoms, and slow the progression of autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
Interaction of Simponi 50mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Simponi 50mg injection, reducing effectiveness by causing undesirable side effects.
Storage Conditions
- Stored in a refrigerator at a temperature between 2°C to 8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to take Simponi 50mg Injection
Simponi 50mg injection is typically administered as a subcutaneous injection, which involves injecting the medication under the skin. The exact method of administration may vary depending on the specific formulation and manufacturer. Patients are often instructed to use a pre-filled syringe or an auto-injector device provided with the medication. Before self-administering, patients should follow the instructions provided by their healthcare provider and the medication's package insert.
Safety Advice for Simponi 50mg Injection
Breast Feeding
The safety of using Simponi 50mg injection while breastfeeding is not well established, and its use during this period should be carefully considered in consultation with a healthcare provider.
Alcohol
Both Simponi 50mg injection and alcohol can affect the liver. This medication is metabolized by the liver, and excessive alcohol consumption can also impact liver function. If an individual has liver conditions or takes other medications that affect the liver, the combined use could have a cumulative effect on liver health.
Liver
Yes, Simponi 50mg injection can affect liver function. Regular monitoring of liver enzyme levels is typically recommended during treatment.
Lungs
Individuals with pre-existing lung conditions, such as chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD), may already be susceptible to respiratory infections. The use of Simponi 50mg injection in such patients should only be done after consultation with a healthcare provider.
Driving
Simponi 50mg injection may cause side effects that can impair driving ability and overall alertness. Common side effects include dizziness, headache, and tremors, affecting coordination and reaction time.
Pregnancy
Simponi pregnancy safety for pregnant women is not fully established, and its use during pregnancy requires consultation with a healthcare provider.
Side Effects
Simponi injection side effects, like all medications, may occur in some people, although not everyone will experience them.
Serious
- Allergic reactions
- Elevated liver enzymes
- Blood disorders
- Immunosupression
Common
- Injection site reactions (pain, redness, swelling)
- Upper respiratory tract infections (e.g., common cold)
- Headache
- Elevated liver enzymes
- Nausea
- Rash or skin reactions
- Upper abdominal pain
- Sinusitis
- Urinary tract infections
Expert tips
-
Ensure you do not have any active infections before starting Simponi 50mg Injection.
-
Regular monitoring of liver function and blood counts is required during treatment.
-
Inform your doctor if you have heart failure, neurological disorders, a history of cancer, or if you need live vaccines before starting treatment.
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Be alert for any allergic reactions to the medication and report them immediately.
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Pediatric and geriatric patients require close monitoring to assess specific risks and benefits.
-
Always communicate your full medical history, current medications, and any concerns with your healthcare provider for safe and informed treatment.
FAQs about Simponi 50mg Injection
Q1.
Is regular monitoring necessary while on Simponi 50mg injection?
Regularly monitoring various health parameters, including liver function and blood tests, is typically recommended while using Simponi 50mg injection.
Q2.
What should I do if I experience side effects or allergic reactions Simponi 50mg injection?
If you experience severe side effects or allergic reactions, seek medical attention immediately and inform your healthcare provider.
Q3.
What are the serious infections that Simponi 50mg injection can increase the risk of?
Simponi 50mg injection can increase the risk of serious bacterial, viral, fungal, and tuberculosis (TB) infections. It's important to be vigilant for signs of infection and report them to your healthcare provider.
Q4.
Can Simponi 50mg injection worsen heart failure symptoms?
Simponi 50mg injection may worsen heart failure symptoms in individuals with a history of heart failure. Close monitoring is important in these cases.
Q5.
Does Simponi 50mg injection increase the risk of malignancies?
There may be a slightly increased risk of certain malignancies, including lymphoma. Discuss your individual risk factors with your healthcare provider.
Fact Box
|
Molecule name: |
Golimumab |
|
Therapeutic class: |
Immunomodulatory Agents |
|
Pharmacological class: |
Tumor Necrosis Factor (TNF) Inhibitors |
|
Indications: |
1. Rheumatoid arthritis 2. Psoriatic arthritis 3. Ankylosing spondylitis 4. Axial spondyloarthritis 5. Ulcerative colitis 6. Juvenile idiopathic arthritis |
References
- Janssen Biologics BV, Electronic medicines compendium (emc), [Revised on Oct 2020] [Accessed on 25th August 2023], https://www.medicines.org.uk/emc/files/pil.5707.pdf
- Janssen Biotech, US Food and Drug Administration, [Revised on August 2011] [Accessed on 25th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125289s0064lbl.pdf
- Eleftherios Pelechas eta l; golimumab for Rheumatoid Arthritis; Journal of Clinical Medicine; [Published on March 2019]; [Accessed on 25/08/2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6463251/
Disclaimer
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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:43 AM (IST)
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