Sutenamo 25mg Tablet consists of the active ingredient Sunitinib. It is classified as a tyrosine kinase inhibitor, which means that it works by blocking certain enzymes called tyrosine kinases that are involved in the growth and spread of cancer cells. This medication is used to treat gastrointestinal stromal tumors (GIST), a rare cancer that can start anywhere in the gastrointestinal tract. This medication is also used to treat advanced kidney cancer and pancreatic cancer called pancreatic neuroendocrine tumors (PNET). Cancer is a disorder in which abnormal cells grow in an uncontrolled manner.  It is not recommended for people under 18. 

Before taking Sutenamo 25mg Tablet, it is important to discuss with the physician if you have blood conditions, heart problems, liver disorders, kidney problems, skin disorders, diabetes, seizures, or thyroid disorders. Also, inform if you have recently had surgery or are about to have surgery. Tell your doctor if you are hypertensive because this medication sometimes causes hypertension as a side effect. Avoid taking grapefruit in any form during the treatment with Sutenamo 25mg Tablet. Check with your dentist if you have any problems in the mouth, such as mouth pain, swelling, or sores inside the mouth, before starting treatment.

Sutenamo 25mg Tablet is used in the treatment of the following conditions: 

• Renal cell carcinoma (RCC)
• Gastrointestinal stromal tumors (GIST)
• Pancreatic neuroendocrine tumors (PNET)
• Medullary thyroid cancer
• Certain kidney cancer

The therapeutic effects of Sutenamo 25mg Tablet include slowing down or stopping the growth and spread of cancer cells in the body, thereby reducing the size and number of tumors. It works by inhibiting the activity of specific proteins known as tyrosine kinases, which are involved in the signaling pathways that control cell growth and division. It can help to prevent cancer cells from growing and spreading by blocking these pathways.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Sutenamo 25mg Tablet and reduce effectiveness by causing undesirable side effects.

• Sutenamo 25mg Tablet should be stored at room temperature, between 68°F and 77°F (20°C and 25°C), in its original package.
• Keep it in the original package.
• Protected from moisture, light, and heat.
• Keep it out of reach from children and pets.

Sutenamo 25mg Tablet is taken orally, in the form of capsules, with a glass of water. The capsules should be swallowed whole and not crushed, chewed, or opened. The recommended dose may vary depending on the type of cancer being treated, the patient's age and weight, and other factors. This medication is usually taken once a day, with or without food, at around the same time each day. If you miss a dose, then do not double the dose to compensate for the missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Side effects related to Sutenamo 25mg Tablet are as follows:

Serious:

• Heart failure or heart attack
• Elevated liver function tests.
• Liver failure
• Proteinuria
• Acute kidney injury
• Interstitial lung disease (inflammation of lung walls)
• Pulmonary arterial hypertension
• Gastrointestinal perforation or fistula
• Haemorrhage (bleeding)
• Hypothyroidism (low thyroid function)
• Hypoglycemia (low blood sugar)

Common 

• Fatigue
• Nausea and vomiting
• Diarrhoea
• Loss of appetite
• Hand-foot syndrome
• Skin discoloration or rash
• High blood pressure
• Headache
• Hair loss
• Changes in taste
• Dry skin or itching
• Nosebleeds

If you have been prescribed Sutenamo 25mg Tablet, it is important to follow your healthcare provider's instructions. During treatment, avoid taking grapefruit or grapefruit juice as it can increase the levels of medication in the blood and potentially increase the risk of side effects. Use a reliable method of birth control while taking the medication and for at least four weeks after the last dose. 

This medication can cause serious side effects, so it is important to be vigilant and informed about your treatment. Make sure to report any symptoms or changes in your health, even if they seem minor. With proper precautions and monitoring, it can be an effective treatment for certain types of cancer.

1. Pfizer, U.S Drug and food safety administration (FDA), [Revised on Dec 2018], [Accessed on 5th April 2023], 
   https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021938s035lbl.pdf
2. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
3. Robert J. Thomson; Majid Moshirfar; Yasmyne Ronquillo, Tyrosine Kinase Inhibitors, [Revised on 21st Jan 2021] [Accessed on 5th April 2023],  
   https://www.ncbi.nlm.nih.gov/books/NBK563322/
4. Pfizer, Electronic Medicines Compendium (EMC) [Revised on Mar 2021] [Accessed on 5th April 2023],  https://www.medicines.org.uk/emc/files/pil.7966.pdf
5. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.