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T-Jaki 5mg Tablet
Last updated on 03 Jul 2026 | 11:55 AM (IST)
₹380
MRP: ₹487.5
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T-Jaki 5 mg Tablet is a prescription medicine used to treat autoimmune conditions such as rheumatoid arthritis and other inflammatory disorders. It contains tofacitinib, a Janus kinase (JAK) inhibitor that works by reducing immune system activity and controlling inflammation. T-Jaki is taken under strict medical supervision as part of a long-term disease management plan.
Sourced from:Manufacturer Authorized Distributor
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₹380
MRP: ₹487.50
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Introduction
T-Jaki 5mg tablet contains the active substance Tofacitinib. It is a disease-modifying anti-rheumatoid drug (DMARDs) that belongs to the class immunomodulators. It is used alone or with other medications to treat rheumatoid arthritis (A condition in which the body attacks its joints, causing pain, swelling, and loss of function) in adults who are unable to take or do not respond to other medications. It is also used to treat psoriatic arthritis (A condition that causes joint pain and swelling, and scales on the skin). It is also indicated for treating adult patients with moderately to severely active ulcerative colitis.
Other uses of T-Jaki 5mg tablet include ankylosing spondylitis (inflammatory disease of the spine). It is also used to treat active polyarticular juvenile idiopathic arthritis, a long-term disease mainly causes pain and swelling of your joints in patients 2 years of age and older. The medicine works by decreasing the activity of the immune system. Inform your physician if you have a severe blood infection, active tuberculosis, and liver problems. Notify your doctor if you ever had or have a hepatitis B infection because this medicine could cause the hepatitis B to become active again.
Do not take T-Jaki 5mg tablet if you are allergic to tofacitinib or any other ingredients of this medicine. Inform your healthcare professional if you have any symptoms of an infection, such as fever, sweating, chills, muscle aches, cough, shortness of breath, weight loss, skin sores, difficulty or pain when swallowing, diarrhea, or stomach pain. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, a history of tuberculosis, high blood pressure, or high cholesterol, and also if you are a current or past smoker.
Uses
Rheumatoid arthritis
Psoriatic arthritis
Ankylosing spondylitis
Ulcerative colitis
Polyarticular juvenile idiopathic arthritis
Juvenile psoriatic arthritis
How T-Jaki 5mg Tablet Works
T-Jaki 5mg tablet is a disease-modifying anti-rheumatic drug (DMARD) in the category of Janus Kinase Inhibitors. Janus kinase is a type of enzyme (tyrosine kinase) involved in the signaling of cytokine receptors. It works by inhibiting Janus kinases and interferes with the transcription of genes involved in cell growth and differentiation.
Interaction of T-Jaki 5mg Tablet with other drugs
Taking T-Jaki 5mg Tablet (tofacitinib) with any of the following medicines can change the effect of either of them and may increase the risk of serious side effects.
Ketoconazole or Clarithromycin (Oral Route) Life-threatening
Use only under strict medical supervision.
These medicines may increase the levels of tofacitinib in the blood and raise the risk of serious infections and side effects.
Rifampicin (Oral Route) Life-threatening
Do not use together.
Rifampicin may reduce tofacitinib levels and decrease its effectiveness.
Other biologic immunosuppressants such as Adalimumab or Etanercept (Injection Route) Life-threatening
Avoid using together.
Concomitant use may greatly increase the risk of serious infections.
Azathioprine or Cyclosporine (Oral/Injection Route) Life-threatening
Do not use together unless advised.
Taking these medicines together may lead to excessive immunosuppression and higher infection risk.
Corticosteroids such as Prednisolone (Oral Route) Moderate
Use with caution.
Concomitant use may further weaken the immune system and increase the risk of infections.
Non-steroidal anti-inflammatory drugs such as Ibuprofen (Oral Route) Moderate
Use carefully.
There may be an increased risk of gastrointestinal side effects when used together.
Live vaccines such as BCG, MMR, or Varicella (Injection Route) Life-threatening
Do not receive during treatment.
This medicine affects the immune system and may increase the risk of infection after vaccination.
Storage Conditions
Store tofacitinb at room temperature (20°C to 25°C)
keep the tablet away from the reach of children and pets.
If you forgot to take a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
Do not take a double dose to make up a forgotten dose.
How to consume T-Jaki 5mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Take the tablet with or without food.
Safety Advice
Breast Feeding
Breastfeeding is not recommended in patients taking T-Jaki 5mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
It is unknown whether it is safe to consume alcohol when taking T-Jaki 5mg tablet. Consult your doctor for more advice.
Liver
T-Jaki 5mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary in severe liver failure. Inform your physician if you have liver problems before initiating the therapy.
Lungs
It is unknown whether T-Jaki 5mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
The drug has no or limited effect on your ability to drive or operate heavy machines. If you face any difficulties, consult your doctor for more advice.
Pregnancy
T-Jaki 5mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 4 weeks after your last dose is necessary.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
Increased cholesterol levels
Headache
Painful urination
Inflammation of the nose
Cough
Shortness of breath
Diarrhea
Skin rashes
Serious
Lung cancer
White blood cell cancer
Heart attack
Fever and chills
Blood in the stool
Stomach pain or abdominal pain
Skin blisters
Expert Tips
Inform your doctor about your vaccination history, as this medicine may interfere with vaccines.
This medicine may affect fertility, so discuss this with your doctor before starting treatment.
Regular lab tests may be required to monitor how well the medicine is working.
Do not breastfeed during treatment and for at least 36 hours after the last dose.
This medicine may increase the risk of bleeding, bruising, or infections, so take precautions to avoid injury and illness.
FAQs about T-Jaki 5mg Tablet
Q1.
What are the cautions of T-Jaki 5mg tablet?
Tell your doctor immediately if you start to have swelling of your face, lips, tongue, throat, arms, or legs or if you are having trouble swallowing or breathing. T-Jaki 5mg tablet can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.
Q2.
Does T-Jaki 5mg tablet cause high cholesterol?
Increased cholesterol levels are one of the side effects of T-Jaki 5mg tablet, your doctor may take regular blood tests to check for serious side effects.
Q3.
Can T-Jaki 5mg tablet cause depression?
No, T-Jaki 5mg tablet does not cause depression. However, many people who have autoimmune conditions also have symptoms of depression. If you're having symptoms of depression, see your doctor right away.
Q4.
Does T-Jaki 5mg tablet cause blood clots?
Yes, blood clots are reported in patients using T-Jaki 5mg tablet for a longer period. Inform your physician if you face any symptoms of a blood clot.
Q5.
How long does it take T-Jaki 5mg tablet to work?
T-Jaki 5mg tablet is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.
Fact Box
Molecule name: Tofacitinib | Therapeutic class: Antirheumatoid |
Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Rheumatoid arthritis 2. Psoriatic arthritis 3. Ankylosing spondylitis 4. Ulcerative colitis 5. Polyarticular juvenile idiopathic arthritis 6. Juvenile psoriatic arthritis |
References
- XELJANZ 5 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. [cited 2023 Mar 25]. Available from: https://www.medicines.org.uk/emc/product/2500/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION - Tofacitinib. [revised on 2018] [cited 2023 Mar 25]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
- ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS - Tofacitinib. [cited 2023 Mar 25]. Available from: https://www.ema.europa.eu/en/documents/product-information/xeljanz-epar-product-information_en.pdf
Disclaimer
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 03 Jul 2026 | 11:55 AM (IST)
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