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Preparation for allogeneic hematopoietic stem cell transplantation in pediatric patients with class 3 beta-thalassemia
Treatment of adenocarcinoma of breast and ovary.
Treatment of superficial papillary cancer of the urinary bladder.

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Thioplan 15mg Injection acts by damaging the genetic material (DNA and RNA) of the cancer cells. It stops the growth and multiplication of cancer by directly attacking DNA. This causes the breakage of DNA strands. The process of cross-linking is crucial in exhibiting toxicity in cancer cells. This leads to the exertion of cytotoxic effect and death of tumor cells.

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Inform your physician about all the prescribed medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products that you take or have taken before the treatment. Certain medications tend to interact with Thioplan 15 mg Injection and can cause undesirable side effects.

"}},{"id":"e8d218f5-6a51-43c8-881a-b8737d90dbca","type":"PARA","position":5,"content_placement":1,"data":{"heading":"More Information about Thioplan 15mg Injection","text":"

Store between 2° to 8°C.
Protect from light.
Keep out of reach of children.

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Thioplan 15mg Injection should be administered by a qualified physician experienced in high-dose chemotherapy and stem cell transplant. Do not self-administer.

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Breastfeeding while on treatment with Thioplan 15mg Injection is not recommended. Consult your physician for advice before breastfeeding.

","imageUrl":"https://assets.mrmed.in/others/file-1674132409667-45039420-Breatfeeding.jpg"},{"id":"c1981781-303d-4288-9db1-552315f1fa2b","advice":"Alcohol","tag":"Consult your doctor","description":"

It is unknown whether it is safe to consume alcohol while taking Thioplan 15mg Injection. Consult your doctor for advice.

","imageUrl":"https://assets.mrmed.in/others/file-1674132415913-10337479-Alcohol.jpg"},{"id":"bb2f4a63-4d5d-4601-9013-c1fa94f3e87f","advice":"Liver","tag":"Consult your doctor","description":"

Inform your physician before taking Thioplan 15mg Injection if you have liver problems. Ensure that your physician monitors your liver functions regularly.

","imageUrl":"https://assets.mrmed.in/others/file-1674132424807-417765861-Liver.jpg"},{"id":"e2bd9b56-ca46-4e95-b195-784cfc0ba34c","advice":"Lungs","tag":"Consult your doctor","description":"

It is unknown whether Thioplan 15 mg Injection can be administered in lung failure patients. Please consult the doctor for more advice.

","imageUrl":"https://assets.mrmed.in/others/file-1674132427859-226731771-Lungs.jpg"},{"id":"7e0b0bc2-6be7-40a2-997b-5bcb43251415","advice":"Driving","tag":"unsafe","description":"

Thioplan 15mg Injection is used with caution while driving as it may cause convulsion, hallucination, delirium, dizziness, headache, and blurred vision.

","imageUrl":"https://assets.mrmed.in/others/file-1674132431331-421990512-Driving.jpg"},{"id":"f506e3b7-642c-4ca8-b175-6aa6726baa24","advice":"Pregnancy","tag":"unsafe","description":"

Thioplan 15mg Injection is unsafe to use during pregnancy as it may cause fetal harm. Hence, Consult your doctor for advice.

","imageUrl":"https://assets.mrmed.in/others/file-1674132401469-949914510-Pregnancy.jpg"}]}},{"id":"7214e03c-1d90-4c19-8b88-c6f0a7cd087b","type":"PARA","position":8,"content_placement":1,"data":{"heading":"Side Effects of Thioplan 15mg Injection","text":"

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

Severe drop in blood cell count
Heart problem
Kidney damage
Nerve damage
Lung toxicity
Liver toxicity

Common:

Cytomegalovirus infection
Hemorrhage
Diarrhea
Blood in urine
Rashes

"}},{"id":"adba2f49-3e68-4650-a8bb-e7fb9fa148db","type":"PARA","position":9,"content_placement":1,"data":{"heading":"Word of Advice","text":"

It is advised to avoid ingestion, inhalation, or skin and eye contact. Skin reactions may occur with accidental exposure. Using gloves and protective clothing to prevent accidental skin contact is recommended. If the Thioplan 15mg Injection solution contacts the skin or mucosa, immediately wash the skin thoroughly with soap and water or rinse the mucosa with water and seek medical attention.

"}},{"id":"908f47d2-ef7a-41cd-912d-240ee5b8260c","type":"FAQ","position":10,"content_placement":2,"data":{"heading":"FAQs about Thioplan 15mg Injection","faq_list":[{"id":"7c28bf9d-4453-4942-91e9-aa8b1a57791b","question":"

Can pregnant women use Thioplan 15mg Injection?

","answer":"

No, It is unsafe to use Thioplan 15mg Injection during pregnancy as it may cause harm to the developing fetus. Consult your doctor before taking this medicine.

"},{"id":"1897217f-0bbd-4b35-a4f4-698e906345bb","question":"

Which is the best area to inject Thioplan 15mg Injection?

","answer":"

Thioplan 15mg Injection is administered intravenously (into a vein) by a doctor or nurse in a medical facility.

"},{"id":"3f3149d4-e950-4739-bbb5-5ce41843f9a0","question":"

Can I drive after taking Thioplan 15mg Injection?

","answer":"

Thioplan 15mg Injection can cause convulsion, hallucination, delirium, dizziness, headache and blurred vision. Avoid driving or operating any machine if you experience any of these side effects.

"},{"id":"f42f6be7-773a-4c4a-89fb-57f18b500da6","question":"

What class of medication is Thioplan 15mg Injection?

","answer":"

Thioplan 15mg Injection belongs to the class of medications known as alkylating agents or antineoplastics.

"},{"id":"ba58ffa6-95fe-4c80-98b3-5c49de38ebd7","question":"

Can I take vaccinations while taking Thioplan 15mg Injection?

","answer":"

No, The live vaccine may interact with Thioplan 15mg Injection. Hence, without consulting your healthcare provider, this medication should not be taken with any vaccinations.

"}]}},{"id":"45ab7fd5-fff3-44bd-811f-aa0ebb318c5a","type":"PARA","position":11,"content_placement":3,"data":{"heading":"Fact Box of Thioplan 15mg Injection","text":"

Molecule name: Thiotepa

Therapeutic class: Alkylating agents

Pharmacological class: Antineoplastics

Indications:

1. Allogeneic hematopoietic stem cell transplantation

2. Adenocarcinoma

3. Superficial papillary cancer of the urinary bladder.

"}},{"id":"8ad57690-6a2e-475e-8f90-8db9f7a4cc03","type":"PARA","position":12,"content_placement":3,"data":{"heading":"References","text":"

ADIENNE SA, [Revised on 15th June 2020] [Accessed on 23 Nov 2022] https://pdf.hres.ca/dpd_pm/00056680.PDF
Pfizer, US Food and Drug Administration, [Revised on Jan 2017] [Accessed on 23 Nov 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208264s000lbl.pdf
Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

"}},{"id":"a52b3d2b-9b82-4451-a2a6-8de8909b2a43","type":"DISCLAIMER","position":13,"content_placement":5,"data":{"heading":"Disclaimer","text":"

MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.

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