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Tofajak-In 5mg Tablet
Last updated on 30 Jun 2026 | 07:14 AM (IST)
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Tofajak IN 5 mg Tablet is an immunosuppressive medicine used to treat autoimmune conditions such as Rheumatoid Arthritis. It contains tofacitinib, which works by blocking specific enzymes involved in the immune response, thereby reducing inflammation, pain, and joint damage. Tofajak IN 5 mg Tablet should be taken as prescribed by a doctor under careful medical supervision as part of a long term disease management plan.
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Introduction to Tofajak-In 5mg Tablet
Tofajak-In 5mg tablet contains the active substance tofacitinib. It is a disease-modifying anti-rheumatoid drug (DMARDs) that belongs to the class immunomodulators. It is used alone or with other medications to treat rheumatoid arthritis (A condition in which the body attacks its joints, causing pain, swelling, and loss of function) in adults who are unable to take or do not respond to other medications. It is also used to treat psoriatic arthritis (A condition that causes joint pain and swelling, and scales on the skin). It is also indicated for treating adult patients with moderately to severely active ulcerative colitis.
Other uses of tofajak-In 5mg tablet include ankylosing spondylitis (inflammatory disease of the spine). It is also used to treat active polyarticular juvenile idiopathic arthritis, a long-term disease mainly causes pain and swelling of your joints in patients 2 years of age and older. The medicine works by decreasing the activity of the immune system. Inform your physician if you have a severe blood infection, active tuberculosis, and liver problems. Notify your doctor if you ever had or have a hepatitis B infection because this medicine could cause the hepatitis B to become active again.
Do not take tofajak-In 5mg tablet if you are allergic to tofacitinib or any other ingredients of this medicine. Inform your healthcare professional if you have any symptoms of an infection, such as fever, sweating, chills, muscle aches, cough, shortness of breath, weight loss, skin sores, difficulty or pain when swallowing, diarrhea, or stomach pain. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, a history of tuberculosis, high blood pressure, or high cholesterol, and also if you are a current or past smoker.
Uses of Tofajak-In 5mg Tablet
- Rheumatoid arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Ulcerative colitis
- Polyarticular juvenile idiopathic arthritis
- Juvenile psoriatic arthritis
Therapeutic Effects of Tofajak-In 5mg Tablet
Tofajak-In 5mg tablet Tablet is a disease modifying anti-rheumatic drug (DMARD) belonging to the category of Janus Kinase Inhibitors. Janus kinase is a type of enzyme (tyrosine kinase) involved in the signaling of cytokine receptors. Tofajak-In 5mg tablet works by inhibiting Janus kinases, and interferes with the transcription of genes involved in cell growth and differentiation.
Interaction of Tofajak-In 5mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of tofacitinb and reduce its effectiveness by causing undesirable side effects.
More Information about Tofajak-In 5mg Tablet
- Store tofacitinb at room temperature (20°C to 25°C)
- keep the tablet away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
- Do not take a double dose to make up a forgotten dose.
How to consume Tofajak-In 5mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Take the tablet with or without food.
Safety Advice for Tofajak-In 5mg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking tofajak-In 5mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
It is unknown whether it is safe to consume alcohol when taking Tofajak-In 5mg tablet. Consult your doctor for more advice.
Liver
It is unknown whether tofajak-In 5mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Lungs
Tofajak-In 5mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary in severe liver failure. Inform your physician if you have liver problems before initiating the therapy.
Driving
The drug has no or limited effect on your ability to drive or operate heavy machines. If you face any difficulties, consult your doctor for more advice.
Pregnancy
Tofajak-In 5mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 4 weeks after your last dose is necessary.
Side Effects of Tofajak-In 5mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Increased cholesterol levels
- Headache
- Painful urination
- Inflammation of the nose
- Cough
- Shortness of breath
- Diarrhea
- Skin rashes
Serious
- Lung cancer
- White blood cell cancer
- Heart attack
- Fever and chills
- Blood in the stool
- Stomach pain or abdominal pain
- Skin blisters
Word of Advice
This medicine may interfere with vaccines, inform your physician about all your vaccination history. This medicine may impair fertility; talk to your doctor before taking this medicine. Your doctor will regularly do lab tests to check whether the medicine is working. Do not breastfeed during the treatment with this medicine and for at least 36 hours after your last dose. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.
FAQs about Tofajak-In 5mg Tablet
Q1.
What are the cautions of tofajak-In 5mg tablet?
Tell your doctor immediately if you start to have swelling of your face, lips, tongue, throat, arms, or legs or if you are having trouble swallowing or breathing. Tofajak-In 5mg tablet can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.
Q2.
Does tofajak-In 5mg tablet cause high cholesterol?
Increased cholesterol levels are one of the side effects of tofajak-In 5mg tablet, your doctor may take regular blood tests to check for serious side effects.
Q3.
Can tofajak-In 5mg tablet cause depression?
No, tofajak-In 5mg tablet does not cause depression. However, many people who have autoimmune conditions also have symptoms of depression. If you're having symptoms of depression, see your doctor right away.
Q4.
Does tofajak-In 5mg tablet cause blood clots?
Yes, blood clots are reported in patients using tofajak-In 5mg tablet for a longer period. Inform your physician if you face any symptoms of a blood clot.
Q5.
How long does it take tofajak-In 5mg tablet to work?
Tofajak-In 5mg tablet is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.
Fact Box of Tofajak-In 5mg Tablet
Molecule name: Tofacitinib | Therapeutic class: Antineoplastics |
Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Rheumatoid arthritis 2. Psoriatic arthritis 3. Ankylosing spondylitis 4. Ulcerative colitis 5. Polyarticular juvenile idiopathic arthritis 6. Juvenile psoriatic arthritis |
References
- XELJANZ 5 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. [cited 2023 Mar 25]. Available from: https://www.medicines.org.uk/emc/product/2500/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION - Tofajak-In 5mg tablet. [revised on 2018] [cited 2023 Mar 25]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
- ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS - Tofajak-In 5mg tablet. [cited 2023 Mar 25]. Available from: https://www.ema.europa.eu/en/documents/product-information/xeljanz-epar-product-information_en.pdf
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 30 Jun 2026 | 07:14 AM (IST)
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