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Salt Composition : Dolutegravir,lamivudine
Manufacturer : EMCURE PHARMACEUTICALS LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Twinaqt Tablet
Twinaqt Tablet is a combination of antiretroviral medicine that contains two active substances, Dolutegravir and Lamivudine. It is indicated to treat Human Immunodeficiency Virus (HIV) in adults and adolescents over 12 who weigh at least 40 kg. HIV infection occurs when a person's immune system is attacked and weakened by the human immunodeficiency virus (HIV). This infection progressively weakens the immune system, making individuals more susceptible to opportunistic infections.
This drug is contraindicated and should not be used if you have any known allergy or hypersensitivity to this tablet or other ingredients in the medication. Antacids can interfere with the absorption of the drug and reduce its effectiveness. It is recommended not to take an antacid within 6 hours before or at least 2 hours after taking this tablet. You can take other acid-lowering medications, such as ranitidine, and omeprazole can be taken simultaneously with this tablet. You must consult your doctor for specific advice on taking acid-lowering medicines in conjunction with this medicine. Taking this tablet during the first weeks of pregnancy or when becoming pregnant may increase the risk of a malformed spinal cord in the baby. Inform your physician if you are pregnant, suspecting, or planning to get pregnant before taking this medicine. The doctor will explain the potential risks and benefits. Breastfeeding is not recommended because the viral infection can pass through breast milk with this Twinaqt Tablet.
Supplements or multivitamins with calcium, iron, or magnesium make the drug too difficult to absorb and reduce its effectiveness. Taking this tablet with food makes it possible to take these supplements concurrently. However, if you take it without food, avoid taking calcium, iron, or magnesium supplements for at least six hours before or two hours after taking the tablet. Consult your doctor for more guidance regarding using these supplements alongside Twinaqt Tablet. This tablet can interact with certain medications, potentially affecting their efficacy or increasing the risk of side effects. It's necessary to inform your doctor about all your medications, including prescription, over-the-counter, and herbal supplements, to ensure no potential interactions.
Uses of Twinaqt Tablet
- Human Immunodeficiency Virus (HIV)
Therapeutic Effects of Twinaqt Tablet
Twinaqt Tablet works by inhibiting different enzymes necessary for the replication of HIV. It blocks the integrase enzyme, preventing the insertion of viral DNA into the DNA of the host immune cells. The other drug inhibits the reverse transcriptase enzyme, essential for converting viral RNA into DNA
Interaction of Twinaqt Tablet with other drugs
Inform your doctor about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Twinaqt Tablet, reducing effectiveness by causing undesirable side effects.
More Information about Twinaqt Tablet
- Store the Twinaqt Tablet at a controlled room temperature of (30°C).
- Keep it out of reach of children.
How to consume Twinaqt Tablet
It is an orally available prescription drug. Your doctor will decide the dose and duration of Twinaqt Tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, or crush the tablet. Swallow the whole tablet with water.
Safety Advices for Twinaqt Tablet
Taking Twinaqt Tablet during the first weeks of pregnancy or when becoming pregnant may increase the risk of a malformed spinal cord in the baby. Inform your physician if you are pregnant, suspecting, or planning to get pregnant before taking this medicine. The doctor will explain the potential risks and benefits.
Breastfeeding is not recommended because the viral infection can pass through breast milk with this Twinaqt Tablet.
It is unknown whether Twinaqt Tablet can be prescribed for patients with lung problems. Consult your doctor if you have any lung disease before starting the treatment.
You should tell your doctor if you have had liver diseases, including hepatitis B or C, before taking Twinaqt Tablet as they may reactivate the virus.
It is unknown whether alcohol may interact with Twinaqt Tablet. Inform your physician if you drink alcoholic beverages.
Avoid driving if you feel unwell, as this Twinaqt Tablet, can make you feel dizzy and less alert.
Side Effects of Twinaqt Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Severe allergic reactions (fever, rash, nausea, diarrhea, shortness of breath, swelling of the face or mouth, tiredness)
- Dizziness, drowsiness
- Stomach pain or discomfort
- Difficulty sleeping, abnormal dreams
- Hair loss
- Muscle pain, joint pain
Word of Advice
To prevent the spread of HIV infection, avoid sharing needles or syringes, which can transmit HIV infections easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items like toothbrushes, razor blades, or anything with body fluids or blood should also be avoided. They should not be shared because HIV can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus.
Since this drug is unsafe for breastfeeding because HIV infection can be passed to the baby in the breast milk, alternative feeding methods can be followed to nourish the infant's growth. If you forget to take Twinaqt Tablet for the entire day, take your usual dose the next day. However, do not double-dose yourself.
Q 1. Can Twinaqt Tablet be used in combination with other drugs?
Twinaqt Tablet can be combined with other antiretroviral drugs as an HIV treatment regimen. Combination therapy involving multiple antiretroviral drugs is the standard approach for treating HIV infection. This combination of medications from different drug classes helps to maximize the effectiveness of treatment and minimize the risk of developing drug resistance.
Q 2. How do the Twinaqt Tablet work?
Twinaqt Tablet work by inhibiting different enzymes that are necessary for the replication of HIV. It blocks the integrase enzyme, preventing the insertion of viral DNA into the DNA of the host immune cells. The other drug inhibits the reverse transcriptase enzyme, essential for converting viral RNA into DNA.
Q 3. How will I receive the Twinaqt Tablet?
Always take Twinaqt Tablet as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, crush, or them. Swallow the whole with water.
Q 4. Whether Twinaqt Tablet are safe for breastfeeding?
Twinaqt Tablet is unsafe for breastfeeding because HIV infection can be easily passed to the baby through the breast milk, so it should be avoided.
Q 5. Who should not take Twinaqt Tablet?
Twinaqt Tablet should not be taken by individuals who are allergic to it or its ingredient`
Fact Box of Twinaqt Tablet
Molecule name: Dolutegravir, Lamivudine
Therapeutic class: Antiretrovirals
2.Lamivudine-Nucleoside reverse transcriptase inhibitors (NRTIs)
Indications: Human Immunodeficiency Virus (HIV)
- ViiV Healthcare UK Limited, Electronic medicines compendium (EMC), [ Revised on May 2021] [ Accessed on 17 May 2023],https://www.medicines.org.uk/emc/files/pil.10446.pdf
- Kandel CE, Walmsley SL, Dolutegravir - a review of the pharmacology, efficacy, and safety with the treatment of HIV, Drug Des Devel Ther., 2015, 7(9), 3547-55, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500604/pdf/dddt-9-3547.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 807-808.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1634-1635.
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