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Xplametta 50mg Injection
Last updated on 21 Apr 2026 | 12:13 PM (IST)
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Introduction to Xplametta 50mg Injection
Xplametta 50mg Injection belongs to the group of medications called platinum-based antineoplastic agents. It consists of the active ingredient Oxaliplatin. It is prescribed to treat stage 3 colon cancer after resectioning (surgical removal) of the primary tumour, metastatic colon and rectum cancer. It is used in combination with other anti-cancer medicines. Colorectal cancer is cancer that usually develops in the rectum and large intestine. It develops from the accumulation of various genetic mutations. Both environmental and genetic factors play a significant role in the origin of colorectal cancer. This medicine works against tumours that are resistant to cisplatin therapy.
The common side effects that are likely to be associated with Xplametta 50mg Injection are a reduced number of blood cells, unpleasant sensation in the throat, diarrhoea, nausea, vomiting, indigestion, heartburn, blood clots, blood in urine, high blood pressure, depression, insomnia, low calcium level. Inform your doctor if these side effects disturb or persist in you.
Inform your doctor if you are allergic to Xplametta 50mg Injection and its ingredients. Before starting treatment with this medication, inform your physician if you have moderate or mild kidney problems, liver problems, or heart disorders. Tell your doctor about all the medicines you are taking, including vaccinations. It is not recommended for pregnant and breastfeeding women.
Uses of Xplametta 50mg Injection
- Treatment of colon and rectal cancer.
Therapeutic Effects of Xplametta 50mg Injection
Xplametta 50mg Injection works by damaging the genetic material, such as DNA and RNA of the cancer cells, that interferes with the growth of cancer cells. It stops their growth and multiplication of cancer cells.
Interaction of Xplametta 50mg Injection with other drugs
Inform your doctor about any medications you are taking or have taken before the treatment with Xplametta 50mg Injection.
More Information about Xplametta 50mg Injection
Store Xplametta 50mg Injection at a temperature below 30°C.
Protect from light.
How to consume Xplametta 50mg Injection
Xplametta 50mg Injection is given by slow injection into one of your veins (an intravenous infusion) over 2 to 6 hours. Your physician will prescribe a dose according to your body surface area.
Safety Advice for Xplametta 50mg Injection
Breast Feeding
It is unsafe to breastfeed during treatment with Xplametta 50mg Injection. Your physician might suggest you stop breastfeeding for some time, depending on your condition.
Alcohol
It is unknown whether it is safe to consume alcohol with Xplametta 50mg Injection. Consult your doctor for any concerns regarding this.
Liver
Inform your physician before starting treatment with Xplametta 50mg Injection if you have liver disease or abnormal liver function. Your physician will prescribe the dose accordingly.
Lungs
Inform your physician before starting treatment with Xplametta 50mg Injection if you have lung disease or abnormal liver function. Your physician will prescribe the dose accordingly.
Driving
Avoid driving or using machinery if you experience side effects like dizziness, nausea, vomiting, vision problems, and other neurological symptoms.
Pregnancy
Xplametta 50mg Injection is unsafe to use during pregnancy; hence it is not recommended. Women should use effective contraception during and after the 4 months of treatment.
Side Effects of Xplametta 50mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Abnormal bleeding or bruising
- Severe allergic reactions
- Continuous diarrhea and vomiting
- Sore throat and fever
- Irregular heartbeat
- Muscle pain and weakness
- Mouth ulcers
- Extreme tiredness and breathlessness
- Headache
- Altered mental function
- Blurred vision
- Seizures
Common
- A reduced number of blood cells
- Unpleasant sensation in the throat
- Diarrhea
- Nausea, vomiting
- High risk of infections
- Indigestion and heartburn
- Blood in urine
- Blood clots
- High BP
- Depression and insomnia
- Low levels of calcium in the blood
Word of Advice
It is suggested that women should use effective birth control for at least four weeks before starting and during treatment with Oxaliplatin. Male patients are advised to use effective contraception during therapy and six months after treatment to avoid fathering children. Before receiving Xplametta 50mg Injection treatment, male patients should get advice on sperm conservation. Pregnant women should not use or handle this drug since it contains cytotoxic substances. Xplametta 50mg Injection is handled exclusively by healthcare professionals who use sterile single-use gloves, protective masks, hats, and goggles. Vaccinations should be avoided when using this drug since they may cause serious side effects.
Q1.
What is Xplametta 50mg Injection used for?
Xplametta 50mg Injection is used to treat colon and rectal cancer. It belongs to the group of medications called Platinum-based antineoplastic agents.
Q2.
Who is contraindicated to taking Xplametta 50mg Injection?
Patients with severe kidney problems, low blood cells, tingling, and numbness in the fingers and breastfeeding mothers should not use Xplametta 50mg Injection. It is also not recommended for patients who are allergic to Xplametta 50mg Injection and its ingredients.
Q3.
Is it safe to become a father while taking Xplametta 50mg Injection?
It is unsafe to become a father while on treatment and six months after treatment. Hence, effective contraceptives must be used during this time. Before receiving Xplametta 50mg Injection treatment, male patients should get advice on sperm conservation.
Q4.
Can I drive while taking Xplametta 50mg Injection?
Treatment with Xplametta 50mg Injection may raise the risk of dizziness, nausea, vomiting, vision problems, and other neurological symptoms that affect walking and balance. Therefore, when receiving Xplametta 50mg Injection treatment, avoid operating heavy machinery and driving.
Q5.
Can I take vaccinations while taking Xplametta 50mg Injection?
No, you should not get vaccinated with "live" or "attenuated" vaccinations, like the yellow fever vaccine, as it may weaken the immune system and cause severe adverse effects. Hence, without consulting your healthcare provider, this medication should not be taken with any vaccinations.
Fact Box of Xplametta 50mg Injection
Molecule name: Oxaliplatin
| Therapeutic class: Platinum compounds |
Pharmacological class: Antineoplastic or anti-cancer agent
| Indication: Colorectal cancer |
References
- Hospira UK Limited, Electronic Medicines Compendium (EMC), [Revised on Dec 2020] [Accessed on 25th Jun 2021], https://www.medicines.org.uk/emc/files/pil.6286.pdf
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
- I.D. Penman, C.W. Lees, Alimentary tract and pancreatic disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 837-920.
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 21 Apr 2026 | 12:13 PM (IST)
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