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Xpreza 300mg Tablet
Last updated on 18 Jun 2026 | 08:05 AM (IST)
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Introduction to Xpreza 300mg Tablet
Xpreza 300 mg tablet consists of the active ingredient Azacitidine. It is used for treating adults with blood conditions, namely Myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia, and Acute myeloid leukemia (AML), if they are considered ineligible for stem cell transplant.
In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer caused by the release of incompletely formed blood cells into the bloodstream. Chronic myelomonocytic leukemia is a rare form of blood cancer caused by an increased number of monocytes of the white blood cells.
Uses of Xpreza 300mg Tablet
- Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
- High-risk Myelodysplastic syndrome (MDS)
Therapeutic Effects of Xpreza 300mg Tablet
Xpreza 300 mg tablet binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.
Interaction of Xpreza 300mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Xpreza 300 mg tablet and cause undesirable side effects.
More Information about Xpreza 300mg Tablet
Store at 25°C. Keep out of reach of children.
How to consume Xpreza 300mg Tablet
Take Xpreza 300 mg only under the supervision of your physician. Your physician will decide the dose based on your height, weight and general condition. The tablet is orally administered. Take it as a whole with water. Do not break, chew or crush the tablet.
Safety Advice for Xpreza 300mg Tablet
Breast Feeding
Consult your physician for advice on taking Xpreza 300 mg tablets if you are a breastfeeding mother
Alcohol
It is not known whether it is safe to consume alcohol with Xpreza 300 mg tablets. Please consult your doctor.
Liver
Inform your physician before you take Xpreza 300 mg tablets if you are diagnosed with a tumor in the liver cells.
Lungs
Inform your physician before taking Xpreza 300 mg tablets if you have any lung problems.
Driving
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Xpreza 300 mg tablets.
Pregnancy
Xpreza 300 mg tablets are not intended for use during pregnancy. Talk to your physician if you are pregnant or think you could be pregnant.
Side Effects of Xpreza 300mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Drowsiness
- Shivering
- Jaundice
- Stomach bloating
- Unusual bleeding or bruising
- Reduced urination
- Increased thirst
- Dizziness
- Confusion
- Chest pain
- Breathlessness
- Allergies
Common:
- Disturbances in the blood count (RBC, WBC, Platelets)
- Nausea, vomiting, diarrhea
- Constipation
- Tiredness
- Skin reactions like redness and pain at the site of the tablet
- Decreased appetite
- Dizziness
- Pain in extremities
- Joint pain
- Stomach pain
- Headache
- Sore nose and throat
- Rashes and bruising
Word of Advice
Inform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this tablet as they worsen the condition. Avoid using this tablet if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects on the developing baby. Take this tablet only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition.
FAQs about Xpreza 300mg Tablet
Q1.
How to use Xpreza 300 mg tablet?
Take Xpreza 300 mg tablet only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. Xpreza 300 mg tablet is orally administered. Take the tablets as a whole with water. Do not chew, break or crush the tablets.
Q2.
Does Xpreza 300 mg tablet cause hair loss?
No, Xpreza 300 mg tablet does not cause hair loss even after using it for a prolonged period of time.
Q3.
How does Xpreza 300 mg tablet work?
Xpreza 300 mg tablet binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.
Q4.
Is Xpreza 300 mg chemotherapy?
Yes. Xpreza 300 mg tablets is a chemotherapy used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).
Q5.
What are the side effects of Xpreza 300 mg tablets?
The common side effects of Xpreza 300 mg tablets are Nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of the skin, dizziness, joint pain, headache, sore throat, and nose.
Q6.
Is it safe to drive after taking Xpreza 300 mg tablets?
It is unsafe to drive after taking this tablet as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking this medication.
Fact Box of Xpreza 300mg Tablet
Molecule name: Azacitidine | Therapeutic class: Anti-metabolites |
Pharmacological class: Anti-Neoplastics | Indications: 1. Treat advanced or metastatic non-small lung cancer (NSCLC), 2. To Treat Advanced or metastatic pancreatic cancer. |
References
- K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741, [Accessed on 5th Apr 2021] https://www.researchgate.net/publication/7094896_Transcriptional_repression_in_eukaryotes_Repressors_and_repression_mechanisms
- Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018 [Accessed on 3rd Apr 2021] https://bmchematol.biomedcentral.com/articles/10.1186/s12878-017-0094-8
- Dr.Reddy’s Laboratories, [Revised on 8th Nov 2018] [Accessed on 5th Apr 2021] https://www.drreddys.com/media/743001/ac-pm-english.pdf
Disclaimer
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Author Details
Written By
Dr. Bhairavi S
Pharm. D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 18 Jun 2026 | 08:05 AM (IST)
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