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Acute myeloid leukemia (AML)
Relapsed acute lymphoblastic leukemia (ALL)

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Zavedos 5mg injection has antimitotic and cytotoxic effects via a variety of modes of action, it intercalates with DNA to form complexes, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, blocking the relegation component of the ligation-religation reaction catalyzed by topoisomerase II. It interferes with ways in which the cells of your body grow and increase in number and is used in the treatment of cancers.

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Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Zavedos 5mg injection and reduce its effectiveness by causing undesirable side effects.

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Store under refrigeration 2º to 8ºC
Protect the medicine from light
keep the injection away from the reach of children and pets.
If you have missed any dosing appointments, inform your doctor and schedule immediately.

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It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

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Breastfeeding is not recommended in patients taking Zavedos 5mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.

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It is unknown whether consuming alcohol is safe during the treatment with Zavedos 5mg injection. Inform your doctor if you are a chronic drinker.

","imageUrl":"https://assets.mrmed.in/others/file-1674132415913-10337479-Alcohol.jpg"},{"id":"c1bad4b0-ed48-4def-8d42-c2e47529e1fa","advice":"Liver","tag":"unsafe","description":"

Zavedos 5mg injection should be used with caution in patients with liver disease. Dose adjustments are necessary. Inform your physician if you have any liver problems before initiating the therapy.

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It is unknown whether Zavedos 5mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

","imageUrl":"https://assets.mrmed.in/others/file-1674132427859-226731771-Lungs.jpg"},{"id":"d8f4918f-315d-4cd3-937c-ece2ef730460","advice":"Driving","tag":"unsafe","description":"

Zavedos 5mg injection may make you feel tired, dizzy, or sleepy. It is unsafe to drive or operate heavy machinery after taking this medicine.

","imageUrl":"https://assets.mrmed.in/others/file-1674132431331-421990512-Driving.jpg"},{"id":"07cb7090-d80b-4557-9fc5-34eacbe72ff9","advice":"Pregnancy","tag":"unsafe","description":"

Zavedos 5mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 6.5 months after your last dose is necessary.

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Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

Hair loss
Itchy skin rash
Diarrhea
Nausea, vomiting
Stomach cramps
Headache

Serious

Abnormal rhythm
Chest pain
Congestive heart failure
Decreased bone marrow function
Liver toxicity
Kidney toxicity
Infections

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Male patient with a female partner of reproductive potential to use effective contraception during the therapy and for 3.5 months after the last dose. Report symptoms of infection, anemia, or bleeding immediately to your doctor. Do not breastfeed during the treatment and for 14 days after the last dose. This medicine may cause infertility in both men and women, inform your doctor if you are planning for pregnancy before initiating the treatment. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy.

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Can I take vitamin supplements with Zavedos 5mg injection?

","answer":"

Certain medications may interact with the effectiveness of Zavedos 5mg injection including prescription, over-the-counter medicines, vitamin or nutritional supplements, and herbal products. Inform your physician about your medication history.

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Is Zavedos 5mg injection cardiotoxic?

","answer":"

Heart problems like cardiac arrest, abnormal heart rhythm, and congestive heart failure may occur in patients receiving this medicine for the long term. Inform your physician if you have any pre-existing heart disorders before initiating the treatment.

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Does Zavedos 5mg injection cause hair loss?

","answer":"

Hair loss is a common side effect of Zavedos 5mg injection. Consult your doctor if you have more hair fall.

"},{"id":"525ac2c9-1e42-4196-a9d8-a3387ea17a6a","question":"

Is Zavedos 5mg injection an antibiotic?

","answer":"

Zavedos 5mg injection is an anthracycline antibiotic, an anti-cancer drug used to treat certain types of cancer.

"},{"id":"1533e9fe-b9d4-43b6-9d8f-9ede268f99bb","question":"

Is Zavedos 5mg injection a Vesicant?

","answer":"

Vesicants are drugs that can result in tissue necrosis or the formation of blisters (irritation and ulceration of surrounding tissue) when accidentally infused into tissue surrounding a vein. This medicine is classified as a vesicant, hence it will be carefully administered to you by the healthcare professional.

"}]}},{"id":"35e14bb1-ee5f-4adc-b238-e6a1f1bea64f","type":"PARA","position":11,"content_placement":3,"data":{"heading":"Fact Box of Zavedos 5mg Injection","text":"

Molecule name: Idarubicin

Therapeutic class: Antineoplastics

Pharmacological class: Anthracyclines

Indications:

1. Acute myeloid leukemia (AML)

2. Relapsed acute lymphoblastic leukemia (ALL)

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Zavedos 5mg Powder for Solution for Injection - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. [revised 2022] [cited 2023 Apr 21]. Available from: https://www.medicines.org.uk/emc/product/5596/smpc
Idamycin - Idarubicin hydrochloride [cited 2023 Apr 21]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/050734s027lbl.pdf
Cersosimo RJ. Idarubicin: an anthracycline antineoplastic agent. Clinical Pharmacy. [revised 1992 Feb 1] [cited 2023 Apr 21];11(2):152–67. Available from: https://pubmed.ncbi.nlm.nih.gov/1551297/

"}},{"id":"46278174-8719-4dc0-a70a-ae82b3fbddcb","type":"DISCLAIMER","position":13,"content_placement":5,"data":{"heading":"Disclaimer","text":"

MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.

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