ZAVEDOS 5MG INJECTION
IDARUBICIN
Manufacturer : PFIZER LTDOrigin of Medicine : United States of AmericaIntroduction:
Zavedos 5mg Injection is a chemotherapy medication containing the active constituent idarubicin. It is used to treat acute non-lymphocytic leukemia and acute lymphocytic leukemia. Both are blood cancers in which different types of white blood cells multiply in an abnormal and uncontrolled manner. It may be given in combination with other medications.
You need to tell your physician if you have infections, liver disorders, kidney disorders, heart disorders, stomach problems, bone marrow disorders, or recently received or are about to have any vaccines before taking Zavedos 5mg Injection. Use effective birth control during the treatment and for at least three months after the last dose.
Before taking Zavedos 5mg Injection, make sure you inform your physician of all the medicines you have recently taken or are currently taking, particularly trastuzumab (anticancer medication). Red coloration of urine, decreased appetite, hair loss, abdominal discomfort, headache, and fever are common side effects of this medication.
Uses of Zavedos 5mg Injection:
- Acute non-lymphocytic leukemia
- Acute lymphocytic leukemia
How Zavedos 5mg Injection works:
Zavedos 5mg Injection inhibits the activity of enzyme topoisomerase II, involved in DNA (genetic material) multiplication of cancer cells. This prevents the growth and multiplication of cancer cells.
Interactions with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More information:
- Keep Zavedos 5mg Injection out of sight and reach of children.
- Store refrigerated at (2°C to 8°C).
References:
- Accord Healthcare Limited, Electronic medicines compendium (emc), [Revised on Feb 2021] [ Accessed on 4th Dec 2021], https://www.medicines.org.uk/emc/files/pil.775.pdf
- Pfizer, US Food and Drug Administration, [Revised on Dec 2014] [ Accessed on 4th Dec 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/050661s014lbl.pdf
- Hanyu Wang et al; The efficacy and safety of daunorubicin versus idarubicin combined with cytarabine for induction therapy in acute myeloid leukemia; Medicine; Published on 12/06/2020; Accessed on 04/12/2021; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302600/
How to use Zavedos 5mg Injection:
It will be given to you by a health care professional.
Safety advice:
Pregnancy:
Zavedos 5mg Injection may harm the unborn baby. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine.
Breastfeeding:
You must not breastfeed while taking Zavedos 5mg Injection. You need to tell your physician if you are breastfeeding before taking this medicine.
Liver:
You need to tell your physician if you have any liver disorders before taking Zavedos 5mg Injection as this medicine is contraindicated in patients with severe liver disorders.
Kidney:
You need to tell your physician if you have any kidney disorders before taking Zavedos 5mg Injection as this medication is contraindicated in patients with severe kidney disorders.
Driving:
Zavedos 5mg Injection may cause side effects that could impair your driving ability. Avoid driving if you are unwell.
Others:
- Talk to your physician if you have heart disorders, stomach problems, bone marrow disorders, or recently received or are about to receive any vaccines before taking Zavedos 5mg Injection.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Common:
- Infections, low blood cell counts
- Loss of appetite
- Nausea, vomiting
- Diarrhea, abdominal pain
- Burning sensation
- Swelling of mucosa in the mouth
- Hair loss
- Reddish color of urine one to two days after taking the medication
- Fever, chills
- Headache
- Skin rash, itching
- Irregular heart rate

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