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Zejula 100mg Tablet
Last updated on 26 Sep 2026 | 08:41 AM (IST)
₹489209
MRP: ₹574363.13
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₹489209
MRP: ₹5,74,363.13
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Introduction
Zejula 100mg Tablet is a prescription medicine used in the treatment of certain types of cancers, primarily ovarian, fallopian tube, and peritoneal cancers. It belongs to the class of Poly (ADP-ribose) polymerase (PARP) inhibitors. By blocking PARP enzymes, which are essential for repairing damaged DNA in cancer cells, Zejula 100mg Tablet prevents the cancer cells from repairing themselves, leading to their death.
Zejula tablet is available in oral tablet form, making it convenient for long-term use as a maintenance therapy after initial cancer treatment. However, patients taking Zejula 100mg Tablet require regular monitoring of blood counts, blood pressure, and heart health, as it may increase the risk of anaemia, hypertension, or other complications. It should not be used during pregnancy or breastfeeding, and patients with pre-existing heart disease, blood disorders, or uncontrolled hypertension must inform their doctor before starting therapy. zejula price varies by retailer and location.
Uses
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Maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.
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Maintenance treatment of recurrent ovarian cancer.
How Zejula 100mg Tablet Works
Cancer cells rely heavily on DNA repair mechanisms to survive and grow. Zejula 100mg Tablet inhibits the PARP enzyme, which plays a key role in repairing damaged DNA. When PARP is blocked, DNA damage accumulates in cancer cells, leading to their death. This is especially effective in tumours with BRCA gene mutations or homologous recombination deficiencies (HRD), but Zejula Cap 100mg is also beneficial in patients without these mutations.
Interaction with Other Drugs
Inform your doctor if you are taking any of the following:
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Prescription medicines (especially chemotherapy drugs or medicines affecting blood pressure or blood counts).
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Over-the-counter (OTC) medicines.
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Herbal products and vitamin supplements.
Some medicines may increase side effects or reduce the effectiveness of Zejula Tablets. Always share your complete medication list with your healthcare provider.
Storage Conditions
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Store at room temperature (15–30°C).
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Protect from moisture and direct sunlight.
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Keep the medicine in its original packaging until use.
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Keep out of reach of children.
How to Use Zejula 100mg Tablet
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Take this medicine exactly as prescribed by your doctor.
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Usually taken once daily, at the same time each day, with or without food.
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Swallow the tablet whole; do not crush or chew.
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Your doctor will adjust the dose based on your body weight, overall health, and blood test results.
Safety Advices
Pregnancy
Zejula 100mg Tablet can harm the unborn baby. Do not use during pregnancy. Inform your doctor if you are pregnant or planning to conceive.
Breast Feeding
Avoid breastfeeding while taking Zejula 100mg Tablet and for at least 1 month after the last dose
Liver
Inform your doctor if you have liver or kidney problems before starting treatment, as dose adjustments may be required.
Alcohol
Limit alcohol consumption, as it may worsen side effects like dizziness, nausea, or liver strain.
Driving
Zejula 100mg Tablet may cause fatigue, dizziness, or weakness. Avoid driving or operating heavy machinery if these effects occur.
Side Effects
Zejula ovarian cancer side effects are:
Serious:
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Severe anaemia (unusual tiredness, pale skin, shortness of breath)
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Thrombocytopenia (unexplained bleeding or bruising)
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Hypertension (severe headache, chest pain, blurred vision)
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Allergic reactions (rash, swelling, difficulty breathing)
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Bone marrow suppression (persistent fever, frequent infections)
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Rare cases of myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML)
Common:
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Nausea and vomiting
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Fatigue
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Loss of appetite
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Constipation
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Insomnia
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Stomach pain
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Headache or dizziness
Expert tips
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Do not start Zejula 100mg Tablet if your blood counts are very low. Your doctor will check before treatment.
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Regular monitoring of blood pressure and complete blood counts is required during therapy.
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If you miss a dose, take it as soon as you remember. Skip the dose if it is almost time for the next one do not double up.
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Inform your doctor if you experience persistent fatigue, unusual bleeding, or sudden changes in blood pressure.
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Continue follow-up visits as advised to monitor treatment response and side effects.
FAQs
Q1.
What is Zejula 100mg Tablet used for?
It is used as a maintenance therapy in ovarian, fallopian tube, or peritoneal cancers after a response to chemotherapy.
Q2.
What is the correct way to use Zejula 100mg Tablet?
Take once daily as prescribed, at the same time each day, with or without food.
Q3.
Does Zejula 100mg Tablet cause hair loss?
Hair thinning may occur in some patients, but it is usually mild compared to chemotherapy.
Q4.
What is the recommended duration of taking Zejula 100mg Tablet?
Duration of treatment depends on your response and tolerance. Continue as advised by your doctor
Q5.
Do I need regular blood tests while on Zejula 100mg Tablet?
Yes. Blood tests are necessary to check blood counts, liver function, and monitor for side effects.
Fact Box
|
Molecule name |
Niraparib |
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Therapeutic class |
Anticancer Drug |
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Pharmacological class |
Poly (ADP-ribose) Polymerase (PARP) Inhibitor |
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Indications |
|
References
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Mansoor Raza Mirza et al., “Zejula 100mg Tablet Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer,” The New England Journal of Medicine, [Dec 2016], showing significant improvement in progression-free survival with Zejula 100mg Tablet https://www.nejm.org/doi/full/10.1056/NEJMoa1611310
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Bradley J. Monk et al., “Zejula 100mg Tablet in Patients with Newly Diagnosed Advanced Ovarian Cancer,” The New England Journal of Medicine, [Jun 2019], PRIMA trial establishing Zejula 100mg Tablet as frontline maintenance therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1910962
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U.S. Food and Drug Administration (FDA), “FDA approves Zejula 100mg Tablet for first-line maintenance of advanced ovarian cancer,” [April 2020] https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-Zejula 100mg Tablet-first-line-maintenance-advanced-ovarian-cancer
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European Medicines Agency (EMA), “Zejula (Zejula 100mg Tablet): EPAR – Product Information,” [Accessed Sept 2025], regulatory details for EU approval https://www.ema.europa.eu/en/medicines/human/EPAR/zejula
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details

Written By
P. Thirumal Reddy
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)

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