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Zilias 2000mg/500mg Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Zilias 2000mg/500mg Injection
Salt Composition
CEFTAZIDIME,AVIBACTAMMarketer
INTAS PHARMACEUTICALS LTD
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Introduction
Zilias 2000mg/500mg Injection contains two medicines in one injection. One is Ceftazidime, which belongs to the group of medications called third-generation cephalosporin antibiotics. The other is Avibactam belonging to the group of medications called beta-lactamase inhibitors. This combination is effective against a wide range of bacteria and is commonly used to treat serious infections such as pneumonia, urinary tract infections, and abdominal infections.
This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Report your physician if you are allergic to any antibiotic group. You may develop fits-like symptoms if you consume too much Zilias 2000/500 Injection. Inform your doctor if you have a history of seizures or epilepsy. Use of this medication can lead to antibiotic-associated diarrhoea, which ranges from mild to severe. If you experience severe diarrhoea during or after treatment, inform your physician.
Zilias Injection should be used cautiously in individuals with impaired kidney function. Your doctor may need to adjust the dosage based on your kidney function and closely monitor your kidney health during treatment. Notify your physician if you are pregnant or breastfeeding. It is necessary to consult this with your physician for more advice.
Uses
Zilias 2000mg/500mg IV infusion is used in the treatment of the following:
- Pneumonia
- Urinary tract infections
- Abdominal infections
How It Works
Ceftazidime is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis, while Avibactam is a beta-lactamase inhibitor. Avibactam helps protect Ceftazidime from being degraded by beta-lactamase enzymes, allowing the antibiotic to kill the bacteria effectively.
Interaction of Zilias 2000mg/500mg Injection with other drugs
Notify your physician about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications interact with Zilias 2000mg/500mg Injection and reduce their effectiveness by causing undesirable side effects.
Storage Conditions
- Store the Zilias 2000mg/500mg Injection at 20°C to 25°C
- Keep the medicine out of reach of children and pets.
How to use Zilias Injection
Do not self-administer the Zilias 2000mg/500mg Injection. Your doctor will decide the duration and dose of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for unwanted side effects.
Safety Advice for Zilias 2000mg/500mg Injection
Breast Feeding
If breastfeeding, consult your doctor before starting the treatment with Zilias 2000mg/500mg Injection.
Alcohol
It is unknown whether consuming alcohol while taking Zilias 2000mg/500mg Injection is safe. Please speak with your physician.
Liver
Consult your physician for advice before starting the treatment with Zilias 2000mg/500mg Injection. If you have liver problems, ensure your physician monitors your liver functions regularly.
Lungs
Zilias 2000mg/500mg Injection is safe to use and can be prescribed for patients with lung problems. Consult your physician if you have any lung diseases before starting the treatment.
Driving
Zilias 2000mg/500mg Injection alters your ability to drive and operate heavy machinery.
Pregnancy
If you are pregnant, suspecting, or planning for the pregnancy, report to your doctor before starting the treatment with Zilias 2000mg/500mg Injection.
Zilias 2000/500 injection side effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Zilias 2000mg/500mg Injection are:
- Severe allergic reactions (swelling of lips, face, or throat, rash, difficulty swallowing or breathing)
- Severe or bloody diarrhoea
Common side effects of Zilias 2000mg/500mg Injection are:
- Fever
- Headache, dizziness
- Itching, redness, or swelling in the injection site
- Stomach pain
- Nausea, vomiting
- Change in the number of certain types of blood cells
- Fungal infections
Expert Tips
- Finish the entire prescribed course of Zilias 2000mg/500mg Injection, even if you start feeling better before completion.
- Stopping the medication suddenly can lead to incomplete treatment and the risk of recurrent or resistant infections.
- Notify your doctor if you have allergies to cephalosporin antibiotics, penicillins, or other medications. Also, report any adverse reactions or side effects you experience during treatment.
FAQs about Zilias 2000mg/500mg Injection
Q1.
Is it necessary to follow a special diet while taking Zilias 2000mg/500mg Injection?
While taking Zilias 2000mg/500mg Injection, drinking adequate fluids, such as water, is generally recommended to support kidney function and prevent dehydration.
Q2.
What is the mechanism of action of Zilias 2000mg/500mg Injection?
Ceftazidime is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis, while Avibactam is a beta-lactamase inhibitor. Avibactam helps protect Ceftazidime from being degraded by beta-lactamase enzymes, allowing the antibiotic to kill the bacteria effectively.
Q3.
What types of infections are treated with Zilias 2000mg/500mg Injection?
Zilias 2000mg/500mg Injection is primarily used to treat complicated urinary tract infections (cUTIs), including pyelonephritis (kidney infection) and complicated intra-abdominal infections (cIAIs). It may also treat hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP).
Q4.
What is the route of administration of Zilias 2000mg/500mg Injection?
Zilias 2000mg/500mg Injection is usually administered through intravenous (IV) infusion. The duration and dosage of treatment are based on the type and severity of the infection and the patient's specific medical condition. The administration is done in a healthcare setting, such as a hospital.
Q5.
Can Zilias 2000mg/500mg Injection cause allergic reactions?
Yes, like other antibiotics, Zilias 2000mg/500mg Injection can cause allergic reactions in some individuals. If you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
Fact Box of Zilias 2000mg/500mg Injection
| Molecule name: Ceftazidime, Avibactam | Therapeutic class: Antibiotics |
Pharmacological class: 1. Ceftazidime- Third generation cephalosporins 2. Avibactam- Beta-lactamase inhibitor | Indications: 1. Pneumonia 2. Urinary tract infections 3. Abdominal infections |
References
- Pfizer Limited, Electronic medicines compendium (EMC), [Revised on June 2022] [ Accessed on 26th June 2023], https://www.medicines.org.uk/emc/files/pil.2465.pdf
- Zavicefta, Annex I summary of Product Characteristics - European Medicines Agency. [ Accessed on 26th June 2023], https://www.ema.europa.eu/en/documents/product-information/zavicefta-epar-product-information_en.pdf
- Allergan USA, Inc, US Food and Drug Administration, [Revised on March 2019] [ Accessed on 14th March 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/206494s005,s006lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Antimicrobial drugs, 7th edition, 2013,728.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Penicillins, Cephalosporins and other Beta-Lactam Antibiotics, 12th edition, 2011, 1498.
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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