• Treatment of allergic conditions
• Rheumatic, blood, skin, eye, and endocrine disorders
• Leukemia and lymphomas (palliative management)
• Pain related to surgery (organ transplants)
• Multiple sclerosis
• Ulcerative colitis

It works by binding to glucocorticoid receptors and inhibits the production of substances (such as prostaglandins) that lead to inflammation and allergies.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Zycort 40mg injection and reduce effectiveness by causing undesirable side effects.

• Store Zycort 40mg injection at controlled room temperature (20°-25°C).
• Protect from sunlight
• Keep it out of reach from children and pets.

Zycort 40mg injection will be administered to you by a healthcare professional in a hospital setting. This injection will be given intramuscularly or intravenously into a vein in your arm. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious

• Allergic reactions (wheezing, swelling of face, difficulty breathing)
• Stomach pain spreading to your back, accompanied by vomiting and loss of consciousness
• Bleeding ulcers
• Infections
• Blood clots in the lung (chest pain, coughing up blood, breathlessness)
• Raised pressure within the skull (lack of energy, drowsiness)
• Blood clots in the leg vein

Common

• High blood pressure, headache
• Swelling
• Ulcers
• Vision problems
• Poor wound healing
• Round or moon-shaped face
• Slow growth in infants, children, and adolescents
• Muscle and bone weakness
• Feeling depressed or high, difficulty in thinking, memory loss
• Acne, bruising
• Thinning of skin

Zycort 40mg injection can cause harm to a developing fetus or nursing baby, so it is important to discuss contraception options and the need to avoid breastfeeding during treatment. This drug can increase the risk of certain eye problems, such as posterior subcapsular cataracts and glaucoma. These conditions can lead to vision loss if not treated properly. Additionally, corticosteroids can weaken the immune system, making individuals more susceptible to secondary ocular infections caused by fungi or viruses. Therefore, it is important to use corticosteroids at the lowest effective dose for the shortest possible duration to minimise the risk of these side effects. If you experience any changes in your vision or eye discomfort while taking Zycort 40mg injection or any other corticosteroid, it is important to inform your doctor right away.

1. Pfizer Limited, Electronic medicines compendium (emc), [ Revised on April 2021] [ Accessed on 7th July 2021], https://www.medicines.org.uk/emc/files/pil.1550.pdf
2. Pfizer, US Food and Drug Administration, [ Revised on Oct 2011] [ Accessed on 7th July 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011856s103s104lbl.pdf
3. Medrol, Food and Drug Administration, (Accessed on March 20, 2023),https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/011153s075lbl.pdf
4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, ACTH, adrenal steroids, and pharmacology of the adrenal cortex, 12th edition, 2011, 1231.
5. KD Tripathi, Essentials of Medical Pharmacology, Corticosteroids, 7th edition, 2013, 288.