This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Allylestrenol is a synthetic progestogen primarily used in obstetrics to support pregnancy, especially in women with a history of miscarriage, preterm labor, or intrauterine growth restriction (IUGR). It mimics the action of natural progesterone, a key hormone responsible for maintaining pregnancy by promoting a stable uterine environment and preventing early contractions. Allylestrenol has a low androgenic profile, making it safe for maternal and fetal health when used appropriately.
Allylestrenol was developed in the 1960s and has been widely used in several countries, including India and Japan, for the prevention of pregnancy-related complications. Though not FDA-approved in the United States, it is included in treatment protocols across many parts of Asia and Europe. In India, it is prescribed under gynaecology and high-risk obstetrics care, particularly for women with a history of threatened abortion or hormone-related pregnancy loss. It is available in oral tablet form, typically 5 mg strength, for once or twice daily dosing.
Mechanism of Action of undefined
Allylestrenol works by simulating the activity of natural progesterone, a hormone essential for establishing and maintaining a healthy pregnancy. It helps strengthen the endometrial lining and suppresses uterine contractions, reducing the risk of miscarriage and preterm labor. By creating a hormone-supportive environment it ensures proper embryo implantation and continued fetal development.
Unlike some other synthetic progestins, Allylestrenol has minimal androgenic or estrogenic effects, making it well-tolerated even during long-term use. Its targeted progestogenic activity makes it especially useful in women with progesterone deficiency or uterine instability.
Uses of undefined
Allylestrenol is used for:
- Preventing threatened and recurrent miscarriage
- Managing preterm labor and uterine irritability
- Supporting pregnancies with intrauterine growth restriction (IUGR)
- Treating habitual abortion caused by luteal phase defects
- Hormonal support in assisted reproductive techniques (off-label)
undefined Drug administaration and Dosage available
Allylestrenol is typically prescribed as a 5 mg oral tablet, taken once or twice daily depending on clinical condition. The duration and dose are determined by the doctor based on pregnancy risk factors and the need for uterine support. It can be taken with or without food and should be used at the same time each day for optimal effectiveness.
It is not available in injectable or extended-release formulations. Therapy is often continued through the first trimester or as advised during antenatal care. Discontinuation is usually gradual to avoid hormonal imbalance.
Warnings, Precautions and Side Effects of undefined
Warnings
- Do not use if the patient has hormone-sensitive cancers (e.g., breast or uterine cancer).
- Avoid use in patients with active liver disease, cholestatic jaundice, or undiagnosed vaginal bleeding.
- Not intended for use in non-pregnancy-related hormonal disorders unless specifically advised.
- Discontinue immediately if allergic reactions like skin rash, swelling, or breathing difficulty occur.
- Caution is advised in patients with a history of thromboembolic disorders, as progestins may increase clot risk.
Precautions
Before starting Allylestrenol, your doctor will evaluate if you have any history of liver problems, blood clots, or hormone-sensitive conditions. Inform your healthcare provider if you’re allergic to any progesterone-based medicines or if you have unusual vaginal bleeding. Though generally considered safe in pregnancy, always take this medicine under supervision.
Let your doctor know if you are breastfeeding, planning pregnancy via IVF, or using other hormonal treatments. Routine check-ups, including ultrasound and blood hormone monitoring, may be done during treatment. Do not stop taking medicine abruptly without medical advice. Carry your antenatal medication list with you, especially in emergencies or hospital visits.
Side Effects
Common side effects:
- Nausea
- Headache
- Dizziness
- Breast tenderness
- Bloating
Serious side effects (seek medical help):
- Sudden chest pain or shortness of breath
- Visual disturbances
- Severe abdominal pain
- Swelling or pain in legs (signs of clot)
- Yellowing of skin or eyes (signs of liver dysfunction)
Word Of Advice
Use Allylestrenol.NPP strictly under medical supervision. Regular follow-ups are essential to monitor the progress of pregnancy and adjust doses if needed. Avoid self-medicating or discontinuing the drug abruptly without consulting your doctor. Inform your healthcare provider about all medications you are taking, and report any unusual symptoms immediately. This medicine is not a general hormone supplement—it is tailored for specific pregnancy-related needs.
Frequently Asked Question
References
Disclaimer
The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.
