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Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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Quick Summary
ATAZANAVIR
Last updated on 31 Mar 2026 | 09:31 AM (IST)
ATAZANAVIR
Atazanavir is an antiretroviral medication containing the active constituent atazanavir. Along with other antiretroviral medications, it is utilized to treat HIV-1 infection. The human immunodeficiency virus (HIV-1) targets and kills immune system cells; if left untreated, the body's capacity to fight diseases declines and results in death. Lactose can be found in this medicine. If you are intolerant to sweets, let your doctor know. Atazanavir received FDA approval on June 20, 2003, to treat HIV-1 infection in adults.
Atazanavir is used to treat HIV -1 Infection.
Atazanavir Tablet is taken orally. The medication is taken once a day, either with or can be taken without food, as directed by your healthcare provider. Swallow the capsule or tablet whole without crushing or chewing it.
Atazanavir may cause various side effects. Common side effects include nausea, diarrhea, headache, rash, and abdominal pain or discomfort. Serious side effects can include severe skin reactions, liver problems, pancreatitis, and immune reconstitution syndrome.
Warnings
Atazanavir carries several important warnings. These include the risk of severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, the potential for liver problems and pancreatitis, the occurrence of immune reconstitution syndrome, the possibility of QT prolongation and associated irregular heartbeat, kidney problems, the increased risk of diabetes and hyperglycemia, fat redistribution, the potential for hypersensitivity reactions, and the likelihood of drug interactions.
Precautions
Precautions while taking atazanavir include regularly monitoring liver function. Close monitoring of kidney function is also recommended. Individuals with existing heart conditions or taking medications that prolong the QT interval should exercise caution. Blood sugar levels may need to be monitored, especially in individuals with diabetes. Any unusual skin reactions or signs of hypersensitivity should be promptly reported to a healthcare professional.
Word of Advice
It is crucial to prioritize safety when considering using Atazanavir or other medication. Avoid its use during breastfeeding to protect the developing fetus. Cautious should be taken in existing heart conditions or medications that prolong the QT interval. Regular monitoring of blood sugar levels is important for individuals with diabetes. By following these precautions and promptly seeking medical attention for any concerning symptoms, individuals can ensure this medication's safe and effective use and optimize their overall treatment experience.
Frequently Asked Questions
Q1.
Can Atazanavir cause changes in body fat distribution?
Yes, Atazanavir, like other HIV medications, can potentially cause changes in body fat distribution. This may include increased fat in the abdomen, breasts, and back of the neck, while the face, arms, and legs may experience fat loss. It is known as lipodystrophy.
Q2.
Is it safe to take Atazanavir with antacids or acid-reducing medications?
Atazanavir should not be taken at the same time as antacids or acid-reducing medications, as they can interfere with the absorption of this medication. It is recommended to separate the doses by a few hours.
Q3.
Can Atazanavir affect hormonal contraceptive effectiveness?
Atazanavir may interact with hormonal contraceptives, such as birth control pills, reducing their effectiveness. Additional or alternative contraceptive methods, such as barrier methods, should be used while taking it. Consult with a healthcare provider for appropriate contraceptive recommendations.
Q4.
Can Atazanavir cause changes in mood or mental health?
In some cases, Atazanavir has been associated with mood changes, including depression and anxiety, if you experience significant changes in mood or mental health while taking it.
Q5.
Can Atazanavir be used in children?
Atazanavir can be prescribed for children with HIV infection, but the dosing and usage may differ compared to adults. The decision to use this medication in children should be made by a pediatric HIV specialist, considering factors such as age, weight, and other individual considerations.
Q6.
Can Atazanavir affect fertility or sperm quality?
Limited studies are available on Atazanavir's effects on fertility or sperm quality. While some studies have suggested potential effects on sperm parameters, it is generally considered that the impact on fertility is unlikely. Discuss your fertility or reproductive health concerns while taking this medicine with a healthcare provider.
Q7.
Can Atazanavir be used as monotherapy (as a single drug)?
Atazanavir is typically used as part of combination antiretroviral therapy (ART) to treat HIV infection. It is not recommended as monotherapy, as it may cause drug resistance and reduced treatment effectiveness.
Q8.
Can Atazanavir cause changes in cholesterol or lipid levels?
Yes, Atazanavir has been associated with changes in cholesterol and lipid levels, such as an increase in total cholesterol and triglycerides. Regular monitoring of lipid levels and appropriate management, such as dietary changes or lipid-lowering medications, may be necessary for individuals taking it.
References
- Bristol-Myers Squibb, US Food and Drug Administration, [ Revised date: OCT 2011], [ Accessed date: 17 May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf
- Dr. Reddy, Electronics Medicine compendium, [ Revised date: NOV 2018], [ Accessed date: 17 My 2023], https://www.medicines.org.uk/emc/files/pil.10778.pdf
- Laurance Brunton, Bruce Chabner, Bjorn Knollman Goodman & Gilman’s, The Pharmacological Basics of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th Edition, 2011, Page: 1623-1660
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.
