This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Fluticasone Furoate and Vilanterol is a combination medication approved for the management of chronic obstructive pulmonary disease (COPD) and asthma. This combination combines the effects of an inhaled corticosteroid (ICS), fluticasone furoate, and a long-acting beta-agonist (LABA), vilanterol. It helps to reduce inflammation and relax airway muscles, improving breathing and lung function.

Mechanism of Action of undefined

Fluticasone Furoate and Vilanterol work synergistically to relieve asthma and COPD symptoms. Fluticasone Furoate, a powerful anti-inflammatory corticosteroid, actively reduces the production of inflammatory mediators in the lungs, controlling airway inflammation. Vilanterol, a long-acting beta-agonist (LABA), stimulates beta-2 receptors in the airway smooth muscles, causing bronchodilation and enhancing airflow. Together, they effectively reduce flare-ups, improve lung function, and provide sustained symptom relief.

Uses of undefined

Fluticasone Furoate and Vilanterol is primarily used to treat COPD and asthma. The combination works synergistically to manage symptoms such as wheezing, shortness of breath, and chronic cough. Fluticasone furoate reduces inflammation in the lungs, preventing exacerbations of asthma and COPD. Vilanterol helps relax the muscles around the airways, easing airflow and making it easier to breathe.

undefined Drug administaration and Dosage available

Fluticasone Furoate and Vilanterol is administered through an inhaler device. Patients are instructed to inhale the medication once daily as directed by their healthcare provider. The inhaler should be primed before use to ensure proper delivery of the medication. It’s important not to exceed the prescribed dosage and to follow the inhalation technique as instructed to maximise the effectiveness of the treatment.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Pregnancy and breast-feeding: Consult your healthcare provider before use if you are pregnant or breastfeeding. The safety of this combination during pregnancy and breastfeeding has not been fully established.
  • Asthma-related risk: LABAs like vilanterol can increase the risk of severe asthma exacerbations. Always use the medication as prescribed, and do not use it for acute attacks.
  • Heart conditions: Fluticasone Furoate and Vilanterol may cause an increased heart rate. Patients with heart problems such as arrhythmias or hypertension should use this medication with caution and under medical supervision.
  • Infections: Fluticasone Furoate can weaken the immune system, increasing the risk of infections, particularly fungal or viral infections in the mouth and throat.
  • Liver or kidney issues: If you have liver or kidney disease, consult your healthcare provider before starting this medication, as adjustments to the dosage may be necessary.

Precautions

Take precautions when using Fluticasone Furoate and Vilanterol to ensure safe and effective use. First, learn and practice the proper inhalation technique to ensure the medication reaches your lungs. Schedule regular medical check-ups to monitor your lung function and detect potential side effects early. Always follow the prescribed dosage and avoid exceeding it, as this may increase the risk of side effects. Never stop using the medication suddenly without consulting your healthcare provider, as this could worsen your asthma or COPD symptoms.

Side Effects

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Fluticasone furoate and Vilanterol:

  • Throat irritation or dryness
  • Coughing or hoarseness
  • Headache
  • Upper respiratory tract infections

Serious side effects of Fluticasone furoate and Vilanterol:

  • Paradoxical bronchospasm (worsening shortness of breath or wheezing)
  • Tachycardia (rapid heart rate)
  • Chest pain or palpitations
  • Oral thrush (fungal infection in the mouth)
  • Corticosteroid-related effects (e.g., weakened immune system, osteoporosis, adrenal suppression)

Word Of Advice

When using Fluticasone Furoate and Vilanterol, it’s important to follow your healthcare provider’s instructions carefully. Adhere to the prescribed dosage and be aware of any potential side effects. If you experience worsening symptoms or any adverse reactions, contact your healthcare provider immediately. Regularly monitor your condition and keep up with follow-up appointments. Avoid using this medication for acute asthma attacks and ensure you have a rescue inhaler available for emergencies. Maintain a healthy lifestyle, including proper diet and exercise, to support your respiratory health.

Frequently Asked Question

References

1. Albertson TE, Richards JR, Zeki AA. The combination of fluticasone furoate and vilanterol trifenatate in the management of asthma: clinical trial evidence and experience. https://pmc.ncbi.nlm.nih.gov/articles/PMC5933662/

2. Prabhudesai P, Singh BP, Agrawal G, Singh AK, Jadhav AY, Patil SR, Bhagat S, Patil S, Barkate H. Fluticasone Furoate/Vilanterol Use Trends and Characteristics in Patients With Obstructive Airway Disease: A Real-World Study of 10,374 Patients From India. https://pmc.ncbi.nlm.nih.gov/articles/PMC10008380/

3. Janson C. Treatment with inhaled corticosteroids in chronic obstructive pulmonary disease. https://pmc.ncbi.nlm.nih.gov/articles/PMC7212119/

Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare provider for specific guidance on diagnosis and treatment.