This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Ticagrelor and Aspirin combination is an antiplatelet medication. Ticagrelor was approved by the US FDA on July 20, 2011, and Aspirin was approved by the US FDA on June 1, 1960. It is used to reduce the risk of heart attack, stroke, and cardiovascular events in patients with acute coronary syndrome (ACS) or those who have had a heart attack.
Mechanism of Action of undefined
Ticagrelor blocks the P2Y12 receptor on platelets, preventing them from becoming activated and forming clots. Aspirin inhibits cyclooxygenase-1 (COX-1), reducing the production of thromboxane A2, which promotes platelet aggregation. Together, they effectively prevent blood clot formation in the arteries. This combination reduces the risk of heart attacks and strokes in high-risk patients.
Uses of undefined
Ticagrelor and Aspirin are used together to reduce the risk of heart attacks, strokes, and other serious cardiovascular events. They work by preventing blood clots from forming in the arteries. This combination is commonly prescribed for patients with acute coronary syndrome or those who have recently had a heart attack.
undefined Drug administaration and Dosage available
Ticagrelor and Aspirin are usually taken orally as tablets. Do not break, chew, or crush the tablets. It is recommended to take them after food to minimise the risk of stomach upset. Consult your healthcare provider for the correct dosage. If you miss a dose, do not double the next dose; instead, consult your healthcare provider for advice.
Warnings, Precautions and Side Effects of undefined
Warnings
- Bleeding Risk: Both Ticagrelor and Aspirin increase the risk of bleeding, including serious internal bleeding. Avoid using them if you have a history of bleeding disorders.
- Heart Issues: Ticagrelor may cause shortness of breath or slow heart rate. Inform your healthcare provider if you have a history of heart problems.
- Liver and Kidney Conditions: Use caution if you have liver or kidney problems, as the drugs may affect these organs.
- Stop Before Surgery: Discontinue Ticagrelor and Aspirin at least 5 days before any surgery or dental procedures to reduce bleeding risk.
- Allergic Reactions: Severe allergic reactions, including swelling and difficulty breathing, may occur. Seek immediate medical help if this happens.
- Avoid Alcohol: Limit alcohol consumption while taking these medications, as it can increase the risk of stomach bleeding.
- Pregnancy and Breastfeeding: Consult your doctor before using these medications if you are pregnant or breastfeeding.
Precautions
Take Ticagrelor and Aspirin with caution if you have a history of bleeding disorders, stomach ulcers, or heart problems. Inform your doctor if you are pregnant, breastfeeding, or planning surgery. Regular monitoring may be required to check for any potential side effects. Always follow your healthcare provider's advice regarding dosage and usage.
Side Effects
Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.
Common side effects of Ticagrelor and Aspirin:
- Headache
- Dizziness
- Nausea
- Bruising
- Stomach pain or discomfort
Serious side effects of Ticagrelor and Aspirin:
- Severe bleeding (e.g., in the stomach or brain)
- Shortness of breath or difficulty breathing
- Chest pain or rapid heart rate
- Unusual tiredness or weakness
- Black or bloody stools
- Vomiting blood
Word Of Advice
It is important to take Ticagrelor and Aspirin exactly as prescribed by your healthcare provider. Do not skip doses or stop taking them without consulting your doctor, as this may increase your risk of serious heart or blood vessel problems. Always inform your healthcare provider of any other medications you are taking. If you experience any unusual bleeding or side effects, seek medical attention immediately.
Frequently Asked Question
References
1. Tomaniak M, Chichareon P, Onuma Y, Deliargyris EN, Takahashi K, Kogame N, Modolo R, Chang CC, Rademaker-Havinga T, Storey RF, Dangas GD, Bhatt DL, Angiolillo DJ, Hamm C, Valgimigli M, Windecker S, Steg PG, Vranckx P, Serruys PW; GLOBAL LEADERS Trial Investigators. Benefit and Risks of Aspirin in Addition to Ticagrelor in Acute Coronary Syndromes: A Post Hoc Analysis of the Randomized GLOBAL LEADERS Trial. https://pmc.ncbi.nlm.nih.gov/articles/PMC6764000/
2. Li J, Sheng Z, Tan Y, Liu C, Zhou P, Zhou J, Chen R, Chen Y, Song L, Zhao H, Yan H. Combined with ticagrelor, 50 mg aspirin daily can reduce bleeding events without increasing ischemic risk compared with 75-100 mg aspirin daily in coronary artery disease patients: insights from the TIFU (Ticagrelor in Fuwai Hospital) study. https://pubmed.ncbi.nlm.nih.gov/31645164/
3. Traby L, Kollars M, Kaider A, Siller-Matula JM, Wolkersdorfer MF, Wolzt M, Kyrle PA, Eichinger S. Differential Effects of Ticagrelor With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers. https://pmc.ncbi.nlm.nih.gov/articles/PMC7006887/
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.