This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Tremelimumab is a type of cancer medicine that helps the immune system recognise and destroy cancer cells more effectively. It belongs to a group of treatments called immunotherapy. After years of study and testing, the U.S. Food and Drug Administration (FDA) approved this medicine in October 2022 for treating certain types of liver cancer. This decision was based on a large clinical study known as the HIMALAYA trial, where the drug showed promising results in improving patient survival when used with another medicine called durvalumab. This combination is now an important option for patients with liver cancer that cannot be removed by surgery.

Mechanism of Action of undefined

This medicine works by helping your immune system do a better job of fighting cancer. Normally, the immune system has “checkpoints” that stop it from attacking healthy cells. But some cancers take advantage of these checkpoints to hide from the immune system. Tremelimumab blocks one such checkpoint called CTLA-4. This “releases the brakes” on the immune system, allowing it to find and kill cancer cells more easily. In simple words, it boosts your body’s natural defence system so it can fight the cancer better.

Uses of undefined

Tremelimumab is used in combination with durvalumab for treating:

  • Unresectable hepatocellular carcinoma (HCC) – a type of liver cancer that cannot be treated with surgery.
  • Non-small cell lung cancer (NSCLC) – in certain situations under special approval or clinical studies.

It may also be studied for other cancers like melanoma and mesothelioma under clinical trials or specialist advice.

undefined Drug administaration and Dosage available

Tremelimumab is not a tablet or capsule. It is given as an intravenous (IV) infusion in a hospital or clinic by trained healthcare professionals. The dose and how often it is given will depend on the type of cancer and your treatment plan. For liver cancer, a one-time dose of 300 mg is commonly given, followed by regular doses of durvalumab every 4 weeks. Your doctor will decide the exact schedule based on your needs.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Not suitable for people with severe autoimmune diseases like lupus or rheumatoid arthritis.
  • Should not be used in pregnancy or while breastfeeding.
  • May cause strong immune reactions affecting different organs.
  • Can interact with other immune-based or steroid medicines.
  • Needs regular blood tests to check liver, kidney, and thyroid function.

Precautions

Before starting treatment, inform your doctor about any past medical problems, especially autoimmune conditions, organ transplants, or chronic infections. Avoid taking any vaccines without your doctor’s advice during the treatment period. Let your doctor know about all the medicines, supplements, or herbal products you are using. During treatment, you’ll need regular check-ups and lab tests to catch any problems early. If you notice anything unusual, don’t wait—reach out to your healthcare provider right away.

Side Effects

Like all medicines, this one can also cause side effects. Some are common and go away on their own, while others may be serious and need medical attention.

Common side effects:

  • Tiredness or weakness
  • Diarrhoea or loose stools
  • Skin rash or itching
  • Feeling sick (nausea)
  • Poor appetite
  • Belly pain
  • Joint or muscle pain

Serious side effects (need doctor’s attention):

  • Lung inflammation (trouble breathing, dry cough)
  • Liver issues (yellow eyes/skin, dark urine)
  • Hormonal changes (fatigue, weight changes, mood swings)
  • Intestinal inflammation (severe stomach pain, bloody stools)
  • Kidney problems (swelling, change in urination)

Report any new or unusual symptoms to your doctor quickly.

Word Of Advice

It’s important to stay alert to how your body feels during this treatment. Since it boosts your immune system, it can sometimes become overactive and harm healthy parts of your body. Don’t skip your follow-up appointments and report any side effects, even if they seem small. Eat light, nutritious food and drink plenty of water to stay energised. Carry a medical card that lists this medicine and let other doctors know you’re receiving immunotherapy, especially in case of emergencies or surgery.

Frequently Asked Question

References

  1. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-disco-burst-edition-fda-approvals-imjudo-tremelimumab-combination-durvalumab-unresectable
  2. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tremelimumab-combination-durvalumab-and-platinum-based-chemotherapy-metastatic-non
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/761289lbl.pdf

Disclaimer

The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.