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Duragen Plus 4IN X 5IN Adhesion
Salt Composition : Adhesive Matrix
Manufacturer : DR REDDY'S LABORATORIES LTD
Origin of Medicine : India
1 Packet(s)
Introduction to Duragen Plus 4in X 5in Adhesion
Duragen Plus 4IN X 5IN Adhesion contains an active component called Adhesive matrix. It is used in procedures where the dura mater, the outermost membrane covering the brain and spinal cord, needs repair due to trauma, surgery, or other conditions causing dural defects. It can also be used in surgeries involving the brain, particularly when there's a need to reinforce or patch the dura following tumor removal, trauma, or vascular surgery. It can also be employed in spinal surgeries to support dural repair, especially during laminectomies or other procedures where the spinal dura needs reinforcement or repair. Cerebrospinal fluid (CSF) leaks, often resulting from trauma or prior surgical interventions, can be repaired using this medication to seal the leak site. After the surgical removal of brain or spinal tumors, this medication can aid in providing support to the dural closure and reducing the risk of cerebrospinal fluid leakage.
Patients with known hypersensitivity to materials present in Duragen Plus 4IN X 5IN Adhesion should not use it. It is not recommended in areas with active infections or contaminated surgical fields, as this could increase the risk of further complications. In cases where bleeding at the surgical site cannot be adequately controlled, the use of this medication might not be advisable due to the potential for increased bleeding or reduced effectiveness. It might only suit some surgical procedures outside its intended neurosurgery or dural repair applications. No specific age-related safety concerns are associated with Duragen Plus 4IN X 5IN Adhesion in older people. However, healthcare professionals should consider individual health conditions and medication interactions before use.
Uses of Duragen Plus 4in X 5in Adhesion
- Dural repair
- CSF leak repair
- Neurosurgical applications
- Tumor resection support
- Trauma and injury management
Therapeutic Effects of Duragen Plus 4in X 5in Adhesion
Duragen Plus 4IN X 5IN Adhesion operates as a bioresorbable membrane with a multi-faceted mechanism of action. Upon placement over damaged tissue, it provides a physical barrier, effectively isolating the damaged area and preventing adhesions between the dural layers or neighboring tissues. This barrier function promotes an environment conducive to healing by supporting the body's natural regenerative processes. Moreover, being bioresorbable, it gradually degrades over time, coinciding with tissue healing. It releases materials that can promote tissue regeneration and repair as it breaks down. This gradual degradation aligns with the body's healing timeline, ensuring the repaired tissue gains strength as the membrane dissolves, eventually becoming integrated into the patient's tissue.
Interaction of Duragen Plus 4in X 5in Adhesion with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the Duragen Plus 4IN X 5IN Adhesion, reducing effectiveness by causing undesirable side effects.
More Information about Duragen Plus 4in X 5in Adhesion
- Stored at controlled room temperature, between 15°C and 25°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Duragen Plus 4in X 5in Adhesion
The Duragen Plus 4IN X 5IN Adhesion is primarily used in surgical procedures and is administered topically or intraoperatively. It's applied directly to the affected area during surgery, typically over dural defects or sites requiring reinforcement or repair. The surgeon places it in the specific location where dural support or sealing is needed, acting as a barrier or support during the healing process.
Safety Advices for Duragen Plus 4in X 5in Adhesion
Pregnancy
There is limited information on using a Duragen Plus 4IN X 5IN Adhesion during pregnancy. Tell your doctor if you are pregnant or planning to get pregnant before taking this medication.
Breast Feeding
Consult your healthcare provider before taking an Duragen Plus 4IN X 5IN Adhesion if you are breastfeeding, as there is limited information on using an Duragen Plus 4IN X 5IN Adhesion during breastfeeding.
Lungs
Consult your health care provider before taking an Duragen Plus 4IN X 5IN Adhesion if you have lung diseases.
Liver
If you have a liver condition or are concerned about the safety of the Duragen Plus 4IN X 5IN Adhesion, it is recommended to consult your healthcare provider for personalized advice.
Alcohol
There are no known interactions between Duragen Plus 4IN X 5IN Adhesion and alcohol. However, if you are recovering from surgery, it is not safe to use it.
Driving
The Duragen Plus 4IN X 5IN Adhesion does not directly impact driving ability. However, consult your healthcare provider for personalized advice.
Side Effects of Duragen Plus 4in X 5in Adhesion
Duragen Plus 4IN X 5IN Adhesion causes some side effects like all medications, although not everyone will experience them.
Serious:
- Infection risk
- Inflammatory reactions
- Adverse tissue responses
- Impaired healing
- Surgical complications
Common:
- Local discomfort
- Swelling
- Redness
- Temporary sensation changes
Word of Advice
Patients with known allergies to any components should avoid Duragen Plus 4IN X 5IN Adhesion. Adherence to strict aseptic techniques during the surgical procedure is essential to minimize the risk of infection associated with the use of it. Ensure correct membrane placement during surgery to avoid displacement or inadequate coverage, which could impact its effectiveness. Patients require monitoring postoperatively for any signs of adverse reactions, such as increased swelling, redness, or unusual pain at the application site. Attend all scheduled follow-up appointments to allow healthcare providers to monitor healing progress and address any concerns or complications. Inform the healthcare team about any unusual or concerning symptoms experienced after the surgery involving this medication. Follow a balanced diet, stay hydrated, and avoid smoking or excessive alcohol consumption, as these factors can impact the body's ability to heal properly. Understand and respect the activity restrictions or limitations the healthcare provider advises to avoid straining the surgical site during the recovery period.
FAQs
Q 1. Is Duragen Plus 4IN X 5IN Adhesion safe for everyone?
Duragen Plus 4IN X 5IN Adhesion usage depends on individual patient conditions and the surgical context. Patients with allergies to its components or those with certain medical conditions might not be suitable candidates for its use.
Q 2. How long does the Duragen Plus 4IN X 5IN Adhesion last in the body?
The Duragen Plus 4IN X 5IN Adhesion is designed to resorb over time, coinciding with tissue healing gradually. Its complete dissolution and integration into the patient's tissue occur over several weeks to months.
Q 3. What should I do if I notice any issues after surgery involving the Duragen Plus 4IN X 5IN Adhesion?
Contact your healthcare provider immediately after using the Duragen Plus 4IN X 5IN Adhesion if you experience unusual pain, swelling, redness, fever, or any concerning symptoms at the surgical site.
Q 4. Can Duragen Plus 4IN X 5IN Adhesion cause allergic reactions?
While rare, allergic reactions to Duragen Plus 4IN X 5IN Adhesion can occur in individuals with known allergies to its components. Patients with a history of allergic reactions should inform their healthcare provider before surgery.
Q 5. Can Duragen Plus 4IN X 5IN Adhesion be reused or reapplied in subsequent surgeries?
An Duragen Plus 4IN X 5IN Adhesion is a single-use medical device and should not be reused. Each application is intended for a specific surgical procedure and should not be reapplied.
Q 6. Are any dietary restrictions or specific care needed after Duragen Plus 4IN X 5IN Adhesion surgery?
Unless advised otherwise by healthcare providers, there are typically no specific dietary restrictions related to Duragen Plus 4IN X 5IN Adhesion. Patients should follow general postoperative care instructions provided by their healthcare team.
Fact Box of Duragen Plus 4in X 5in Adhesion
Molecule name: Adhesive matrix | Therapeutic class: Bioresorbable membranes |
Pharmacological class: Scaffolds | Indications: 1. Dural repair 2. CSF leak repair 3. Neurosurgical applications 4. Tumor resection support 5. Trauma and injury management |
References
- Ganti SS, Bhattaccharjee SA, Murnane KS, Blough BE, Banga AK.Formulation and evaluation of 4-benzylpiperidine drug-in-Duragen Plus 4IN X 5IN Adhesion type transdermal patch. Int J Pharm. 2018 Oct [Accessed on 17th Nov 2023],https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195313/
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