Acaone 100mg Capsule is an anticancer medicine containing the active constituent Acalabrutinib. It belongs to a class of drugs called Bruton's tyrosine kinase (BTK) inhibitors. It is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL), and small lymphocytic lymphoma (SLL). MCL, CLL, and SLL are cancers of the white blood cells called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs and the type of lymphocytes affected.

Before taking this medicine, inform your doctor if you have had recent surgery, bleeding problems, heart rhythm problems, infection, pregnancy, or breastfeeding. It is not recommended for children and adolescents less than 18 years old. This medicine can increase the risk of bleeding. Patients taking Acaone 100mg Capsule should be monitored for signs of bleeding and should avoid taking other medications that can increase the risk of bleeding, such as blood thinners. Acaone 100mg capsule price varies by retailer and location. You can buy Acaone 100mg online. Acaone 100mg substitutes include Acaone 100mg is Isotretinoin 10–20mg, depending on the prescribed dose and patient condition.

The Acaone 100mg uses in the treatment of

• Chronic lymphocytic leukemia

• Small lymphocytic lymphoma

• Mantle cell lymphoma

The therapeutic effect of Acaone 100mg Capsule is to inhibit the activity of Bruton's tyrosine kinase (BTK), a protein that is essential for the survival and growth of cancer cells in certain types of lymphomas and leukemias. By blocking BTK, it can help to slow down or even stop the growth and spread of cancer cells, which can lead to a reduction in tumor size, an improvement in symptoms, and a delay in disease progression.

1. Taking Acaone 100 mg Capsule with any of the following medicines can modify the effect of either of them and cause some undesirable side effects:

2. Insulin (Injection Route) Moderate
   Using insulin with acarbose may increase the risk of low blood sugar.

3. Glimepiride (Oral Route) Moderate
   The combination may enhance hypoglycemic effects and requires blood sugar monitoring.

4. Digoxin (Oral Route) Moderate
   Acarbose may reduce blood levels and effectiveness of digoxin.

5. Digestive Enzyme Preparations (Oral Route) Severe
   Digestive enzymes may reduce the effectiveness of Acaone by interfering with its action in the gut.

• Store in a refrigerator between 20°C to 25°C (68°F to 77°F).

• Keep away from moisture, heat, and light.

• It should not be frozen.

• Keep it in its original packaging until it is ready to be used.

• Keep out of the reach of children and pets.

Acaone 100mg Capsule is typically taken orally, with or without food. The tablets should be swallowed whole, not crushed, chewed, or broken. The recommended dosage can vary depending on the type of cancer being treated and other factors such as your overall health and response to treatment. Do not take a double dose to make up for a missed dose.

Acaone 100mg capsule side effects, although not everyone will experience them. 

Serious:

• Bleeding problems (bruising or bleeding)

• Infections (pneumonia and sepsis)

• High blood pressure

• Heart problems (irregular heartbeat and chest pain)

• Kidney failure

Common:

• Headache

• Diarrhea

• Nausea

• Fatigue

• Muscle and joint pain

• Bruising or bleeding easily

• Upper respiratory tract infection

• Rash or itching

• Allergic Reactions: Monitor for any signs of an allergic reaction and report immediately to your doctor.

• Blood Pressure: The medication can raise blood pressure, so check it regularly.

• Skin Changes: Inform your doctor if you notice any new lesions or changes in existing skin areas.

• Infection Risk & Diabetes: Avoid contact with infected individuals; patients with diabetes should be closely monitored.

• Pregnancy, Breastfeeding & Diet: Avoid use during pregnancy and breastfeeding, and maintain a healthy, balanced diet for overall well-being.

1. AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023], https://www.medicines.org.uk/emc/files/pil.11917.pdf

2. AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf

3. John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on 5th May 2023];  https://pubmed.ncbi.nlm.nih.gov/31876911/