ACOSEV 400MG TABLET

Introduction:

Acosev 400mg Tablet is indicated to control serum phosphorous levels in patients with chronic kidney disease on dialysis. Phosphate gets accumulated in the body in case of acute and chronic kidney injury. Hyperphosphatemia is a common complication of chronic kidney disease and hypoparathyroidism. High levels of phosphorous in your blood could lead to deposits in your bone called calcification. Calcification stiffens your blood and makes pumping of blood difficult. Hyperphosphatemia could also lead to itchy skin, red eyes, bone pain and fractures. This can be controlled by incorporating restricted dietary intake of phosphorous and adding phosphate binding drugs and calcium supplements to the medication regimen.

Uses of Acosev 400mg Tablet:

• Treatment of hyperphosphatemia in patients undergoing dialysis
• Treatment of hyperphosphatemia in patients with chronic kidney disease
• Adjunct to calcium and Vitamin D supplements to prevent bone disease

How Acosev 400mg Tablet works:

Acosev 400mg Tablet binds to phosphate in the food present in the digestive tract, inhibits its absorption by the body and reduces the levels of phosphorous in the blood.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

This medicine does not require special storage conditions. Keep this medicine away from the sight and reach of children.

References:

1. Zentiva Pharma UK Limited, Electronic Medicines Compendium (EMC), [Revised on Aug 2019] [Accessed on 4th Jun 2021], https://www.medicines.org.uk/emc/files/pil.8679.pdf
2. Genzyme Corporation, US Food and Drug Administration, [Revised on Nov 2014] [Accessed on 4th Jun 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022127s011lbl.pdf
3. J. Goddard, A.N. Turner, Kidney and urinary tract disease, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 461-523.
4. Daniel D. Bikle, Agents That Affect Bone Mineral Homeostasis, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 772-791.

How to use Acosev 400mg Tablet:

Take Acosev 400mg Tablet with meals. Do not crush, chew or break the tablets into pieces. Swallow the tablet whole with water. Your physician will prescribe the dose based on your serum phosphorous levels.

Safety Advice:

Pregnancy:

Inform your physician before taking Acosev 400mg Tablet if you are pregnant or think you might be pregnant.

Breastfeeding: 

It is not known if Acosev 400mg Tablet is excreted in milk. Consult your physician for advice.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Your physician will monitor your liver functions regularly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions, calcium and Vitamin D levels regularly.

Allergies: 

Inform your physician if you experience allergic reactions to or its ingredients.

Others:

• Talk to your physician if you have problems with swallowing, stomach or bowel movements, or if you have recently undergone a major surgery involving your stomach or bowel.

Side Effects:

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Intestine or bowel obstruction

Common:

• Nausea, vomiting, abdominal pain
• Diarrhea, flatulence, indigestion
• Constipation