The Afrezza Inhaler Device is used to administer rapid-acting inhaled insulin for:

• Mealtime blood glucose control in adults with type 1 diabetes (used in combination with long-acting basal insulin).
  

• Mealtime blood glucose control in adults with type 2 diabetes who require insulin therapy.
  

• Reduction of postprandial (after-meal) blood sugar spikes.

When used with Afrezza insulin cartridges, the inhaler delivers insulin directly to the lungs, where it is rapidly absorbed into the bloodstream. This leads to a faster onset of action than many rapid-acting injectable insulins. The insulin begins working within minutes of inhalation, closely mimicking the body’s natural insulin response to meals.

This rapid absorption helps improve post-meal glucose control and reduces prolonged insulin exposure, which may lower the risk of delayed hypoglycemia. Consistent use as prescribed supports better overall glycaemic control when combined with diet, exercise, and basal insulin where required.

The Afrezza Inhaler Device itself does not interact with medications. However, the inhaled insulin delivered through it may interact with certain drugs that affect blood glucose levels. Inform your healthcare provider about all medicines, supplements, and herbal products you are taking. Important interactions include:

• Beta-blockers: May mask symptoms of hypoglycemia.
  

• Corticosteroids: Can increase blood glucose levels and reduce insulin effectiveness.
  

• Thiazide diuretics: May impair glucose tolerance.
  

• Sympathomimetic drugs: Can raise blood sugar levels.
  

Dose adjustments and closer glucose monitoring may be required when these medicines are used concurrently.

• Store the Afrezza Inhaler Device at room temperature in a clean, dry place.
  

• Do not wash the inhaler with water or cleaning agents.
  

• Replace the inhaler as recommended by the manufacturer, even if it appears to be functioning.
  

• Use only Afrezza insulin cartridges with this device.
  

• Keep the device out of reach of children.
  

• Do not share the inhaler with others, even if cartridges are changed.

To use the Afrezza Inhaler Device:

1. Wash and dry your hands thoroughly.
   

2. Remove one Afrezza insulin cartridge from its blister pack just before use.
   

3. Open the inhaler and place the cartridge inside as instructed.
   

4. Close the inhaler fully until it clicks.
   

5. Exhale fully away from the inhaler.
   

6. Place the mouthpiece in your mouth and inhale deeply and steadily.
   

7. Hold your breath briefly, then remove the inhaler.
   

8. Open the device and discard the used cartridge.
   

9. Close the inhaler and store it properly.
   

Always follow the usage instructions provided by your healthcare professional or the manufacturer.

Common Side Effects:

• Cough
  

• Throat irritation
  

• Hypoglycemia
  

• Headache
  

Serious Side Effects:

• Bronchospasm
  

• Decline in lung function
  

• Severe hypoglycemia
  

• Allergic reactions
  

Seek immediate medical attention if you experience breathing difficulty, chest tightness, or severe allergic symptoms.

• Complete lung function testing before starting inhaled insulin therapy, as advised by your doctor.
  

• Use the Afrezza Inhaler Device strictly according to medical instructions.
  

• Do not change insulin cartridges or doses without consulting a healthcare professional.
  

• Monitor blood glucose levels regularly to ensure proper diabetes control.
  

• Inform your doctor immediately if you experience a persistent cough or breathing discomfort.
  

• Maintain consistency in use, follow the correct inhalation technique, and attend routine follow-up appointments for safe and effective diabetes management.