• Treatment of Hypertension

Amlodipine blocks calcium entry into the smooth muscle cells of blood vessels and the heart. This action leads to the relaxation and widening of blood vessels, reducing peripheral resistance and improving blood flow. Atenolol is a beta blocker that primarily acts on the heart by blocking the effects of adrenaline and noradrenaline. Doing so reduces the heart rate, decreases the force of contraction of the heart muscles, and lowers blood pressure.

Inform your healthcare provider about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Amlodac AT Tablet and reduce effectiveness by causing undesirable side effects.

• Store Amlodac AT Tablet at room temperature (25°C).
• Keep the tablet out of reach of children and pets.

It is an orally available prescription drug. Your doctor will decide the duration and dose of the drug based on the disease condition and other factors. Always take an Amlodac AT Tablet as prescribed by your doctor. Take the tablet with or without food. Do not open, break, chew, or crush the tablet. Swallow the whole tablet with water.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

• Ankle swelling
• Slow heart rate
• Palpitations
• Nausea
• Edema (swelling)
• Muscle cramps
• Constipation
• Tiredness
• Cold extremities
• Sleepiness
• Headache

Before starting Amlodac AT Tablet, or any medication, inform your healthcare professional about any existing medical conditions, allergies, or medications you take for other issues. This detail will help them to decide if this tablet suits them and if any precautions or adjustments are necessary. Avoid exceeding the recommended dose or frequency of use unless your doctor advises. This tablet should be stored in a safe place, out of the reach of children. Accidental ingestion of this drug by children can be harmful.

1. IPCA Laboratories UK Ltd, Patient information leaflet, Atenolol Film-coated Tablets - medicines (EMC). [Revised on March 2022], Available at: https://www.medicines.org.uk/emc/files/pil.14693.pdf (Accessed 07 June 2023).

2. Dr. Reddy's Laboratories (UK) Ltd, Patient information leaflet, Amlodipine- medicines (EMC). [Revised on July 2022], Available at: https://www.medicines.org.uk/emc/files/pil.3473.pdf (Accessed 07 June 2023).

3. Amlodipine- Food and Drug Administration (FDA). [Revised on May 2011], Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s047lbl.pdf#:~:text=Adult%20recommended%20starting%20dose%3A%205%20mg%20once%20daily,2.5%20mg%20to%205%20mg%20once%20daily.%20%282.2%29 (Accessed 07 June 2023).

4. Package leaflet: Information for the user - Amlodipine. www.hpra.ie. [Revised on Feb 2018], Available at: https://www.hpra.ie/img/uploaded/swedocuments/2200075.PPA0465_439_001.8ff70424-403e-494c-a327-b60146c559ae.000001Product%20Leaflet%20Approved.180316.pdf (Accessed 07 June 2023).

5. Package leaflet: Information for the user - Atenolol. www.hpra.ie. [Revised on June 2017], Available at: https://www.hpra.ie/img/uploaded/swedocuments/PIL-2194090-22062017180446-636337515623281250.pdf (Accessed 07 June 2023).

6. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Adrenergic agonists and Antagonists, 12th edition, 2011, 327.

7. K. D. Tripathi, Essentials of Medical Pharmacology, Antiadrenergic drugs and glaucoma, 7th edition, 2013, 149.