• Metastatic castration-sensitive prostate cancer.
• Non-metastatic castration-resistant prostate cancer.

Apnat 60 mg is a selective androgen receptor (AR) inhibitor that binds directly to the androgen receptor binding domain. It inhibits protein transportation in the nucleus, DNA binding, and AR-mediated transcription. Treatment with this medicine reduces cancer cell growth and increases cell death, resulting in effective anticancer activity.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Apnat 60 mg and reduce effectiveness by causing undesirable side effects. 

• Store Apnat 60 mg in the original package at room temperature (20°C to 25°C)
• keep the tablets away from the reach of children and pets.
• If you missed a dose, do not take a double dose for the forgotten dose.
• If you have overdosed Apnat 60 mg tablets or someone accidentally takes your tablet, contact the hospital or a doctor immediately for medical advice.

Apnat 60 mg is an orally administered drug. Take medicine as informed by your physician. It is usually taken with or without food once a day. Take medicine at around the same time every day. Swallow the tablets whole; do not split, chew, or crush them.  Do not stop taking this without talking to your doctor.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common:

• Increased cholesterol levels
• Increased blood pressure
• Swelling in lower legs or hands
• Rash and reddening of the skin
• Decreased body weight and loss of appetite
• Diarrhea and nausea
• Muscle pain
• Tiredness and dizziness

Serious:

• Anemia
• Heart disease, stroke or mini-stroke
• Increased blood sugar levels
• Decreased white blood cells
• Fractures of bones
• Seizures and cerebrovascular events
• Severe skin reactions
• Falls

Inform your physician if you have any heart, kidney, liver, or lung disorders before the treatment. Your doctor might give you other medicines unless you had surgery to lower the amount of testosterone in your body. Continue taking this medicine with all the other medications that your doctor prescribes. Apnat 60 mg may cause birth defects if your male partner uses this medicine while planning for pregnancy. Use effective birth control pills or methods during the treatment and for 3 months after the last dose. Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Do not stop using this medicine, even for a short time, without first asking your doctor.

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2. 2021 (2021). Apalutamide: MedlinePlus Drug Information. [online] medlineplus.gov. Available at: https://medlineplus.gov/druginfo/meds/a618018.html  [Accessed 13 Jan. 2023].
3. PATIENT INFORMATION ERLEADA ® (er lee’dah) (apalutamide). (2022). [online] Available at: https://www.janssenlabels.com/package-insert/product-patient-information/ERLEADA-ppi.pdf  [Accessed 13 Jan. 2023].
4. www.cancer.gov. (2018). Apalutamide - National Cancer Institute. [online] Available at: https://www.cancer.gov/about-cancer/treatment/drugs/apalutamide  [Accessed 13 Jan. 2023].