ASVIIA 3750IU/5ML INJECTION

Introduction:

Asviia 3750IU Injection is a chemotherapy drug containing the active constituent pegaspargase. It is used to treat a type of blood cancer called Acute Lymphoblastic Leukemia (ALL). Acute Lymphoblastic Leukemia is a white blood cell cancer in which the immature white cells start growing out of control, thus preventing the production of functional blood cells. Tell your doctor if you suffer from any bleeding disorders, liver diseases, or abdominal pain before taking medicine. Glucose intolerance can occur with the administration of Asviia 3750IU Injection. 

Ask your doctor for advice if you are breastfeeding or pregnant before taking Asviia 3750IU Injection. Avoid driving or handling machines while taking this medicine, as it may make you feel drowsy. Contact your doctor if you experience any severe headaches, abdominal pain, excessive thirst, or serious allergic reactions while taking this medicine.

Uses of Asviia  3750IU Injection:

• Acute Lymphoblastic Leukemia

How Asviia 3750IU Injection works:

Pegaspargase is an enzyme that breaks down asparagine, a vital building block of proteins without which cells cannot survive. Normal cells can produce asparagine for themselves, while cancer cells cannot. This medication lowers asparagine level in blood cancer cells and prevents the cancer cells from growing.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep out of sight and reach of children.
• Store in refrigerator at 2°C to 8°C protected from light. Do not freeze.

References:

1. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 868.
2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1720.
3. Les Laboratories Servier, Electronic medicines compendium (emc), [ Revised on Nov 2020] [ Accessed on 30th April 2021], https://www.medicines.org.uk/emc/files/pil.10824.pdf
4. Sigma-Tau Pharmaceuticals, US Food and Drug Administration, [ Revised on March 2011] [ Accessed on 30th April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf

How to use Asviia 3750IU Injection:

The Asviia 3750IU Injection will be administered by your health care professional. 

Safety advice:

Pregnancy: 

There are no established adverse effects of Asviia 3750IU Injection in pregnant women. Inform your doctor if you are pregnant or planning to get pregnant before taking this medicine. It will be given to you only if it is needed.

Breastfeeding:

Inform the physician before taking this medicine if you are breastfeeding. It will be given to you only if necessary.

Liver:

Inform your physician if you have any liver diseases.

Driving:

This medicine may cause drowsiness; consult your doctor before driving and handling heavy machinery while taking this medication.

Others:

• Inform your doctor if you suffer from fever, bleeding disorder, or severe abdominal pain.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious: 

• Severe stomach pain that spread to your back
• Severe allergic reactions (rash, itching, swelling, shortness of breath, fast heartbeat, and drop in blood pressure)
• Severe bleeding
• Low counts of white blood cells
• Seizures, loss of consciousness

Common: 

• Problems with liver
• Infection with high fever
• Blood clots
• Increase in sugar levels