Avastimab 100mg Injection is an anticancer medicine consisting of the active ingredient Bevacizumab. This medicine is developed to prevent the growth of tumors. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube, or primary peritoneal cancer. Use effective birth control during treatment and for at least six months after the last dose. Avastimab 100mg Injection uses include slowing tumor growth and improving treatment outcomes in multiple cancer types. Avastimab 100mg Injection price may vary based on brand and availability. This injection is not recommended for adolescents and children under the age of 18. Discuss with your doctor about the preservation of ovaries if you are planning for pregnancy in the near future, as this medicine may cause fertility issues in women. It is best to avoid breastfeeding your baby as this medicine may interfere with growth and development.

Avastimab 100mg Injection is often administered as a combination with other chemotherapy agents. Constipation, appetite loss, runny nose, fever, skin problems, and weight loss are common Avastimab 100mg Injection side effects. Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, or heart problems. This medicine should not be taken for 28 days before and after surgery as it is associated with poor wound healing and high bleeding complications. It is advised to report to your doctor if you have any dental issues that require surgery before taking this medicine. In case you develop any visual changes or confusion, report them immediately to prevent complications. If you are looking for cost details, consult your pharmacy for the current Avastimab 100mg price in India.

Avastimab 100mg Injection is indicated to treat the following conditions:

• Glioblastoma multiforme (brain cancer)

• Persistent, recurrent, or metastatic breast cancer

• Metastatic cervical cancer

• Advanced kidney cancer

• Metastatic colorectal cancer

• Advanced non-small-cell lung cancer

• Liver Cancer- Hepatocellular carcinoma

• Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Bevacizumab is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

1. Chemotherapy Drugs

• May interact with cisplatin, carboplatin, paclitaxel, docetaxel, and irinotecan.

• Can increase the risk of kidney problems, low blood counts, and digestive side effects.

2. Blood Thinners & Antiplatelet Medicines

• Warfarin, Heparin, Aspirin, Clopidogrel, Apixaban may increase bleeding risk.

• Requires close monitoring if taken together.

3. Blood Pressure Medications

• ACE inhibitors, ARBs, beta-blockers, and diuretics may need dose adjustments.

• Avastimab can raise blood pressure during treatment.

4. Steroids & Immunosuppressants

• Prednisolone, Dexamethasone, Tacrolimus, and Cyclosporine may raise the risk of infections.

• May also delay wound healing.

5. Diabetes Medications

• Insulin and oral antidiabetic drugs may cause blood sugar fluctuations.

• Regular glucose monitoring is recommended.

6. NSAIDs (Pain and Fever Medicines)

• Ibuprofen, Naproxen, Diclofenac increase the risk of stomach bleeding and poor wound healing.

• Use cautiously during Avastimab therapy.

7. Herbal Supplements

• Ginkgo biloba, Garlic, Ginseng, Turmeric may increase bleeding tendencies.

• Avoid without medical approval.

8. Other Medications

• Any new prescription or OTC drug may interact with Avastimab 100mg Injection.

• Always consult your doctor before adding new medicines.

• Store Avastimab 100mg Injection at 2˚C to 8˚C. Do not freeze or shake.

• Protect from light. Keep out of reach of children.

Your physician or nurse will administer Avastimab 100mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious: 

• Headache

• Vision changes

• Confusion

• Severe allergic reactions

• High Blood pressure

• Delayed wound healing following surgery

• Protein in urine

• Severe infections

• Blood clots in arteries and blood vessels of lungs

• Gut perforation

• Nosebleeds and bleeding risk

• Heart problems with an increase in heart rate

• Mouth sores, dryness

• Shortness of breath

Common:

• Numbness in hands or feet

• Weakness and lack of energy

• Diarrhoea, nausea, vomiting, abdominal pain

• Constipation

• Loss of appetite

• Weight loss

• Changes in taste and speech

• Decrease in counts of white blood cells

• Fever

• Dry skin

• Back pain

It is vital to inform your physician before taking Avastimab 100mg Injection if you have the following conditions:

• Have conditions involving inflammation in the stomach (ulcer, colitis).

• Experience allergic reactions to Avastimab 100mg Injection or its ingredients.

• Have recently undergone surgery as it is associated with the risk of bleeding.

• Have diabetes, hypertension, or heart problems.

1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf 
2.  G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976. 
5. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf 
6. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html