BDENZA 80MG CAPSULE

Introduction:

Bdenza 80mg Capsule consists of the active substance Enzalutamide. It is an anti-cancer drug that belongs to the class of medicines called Androgen Receptor Inhibitors. It is used in the treatment of advanced prostate cancer in patients who do not respond to surgical or hormonal treatments.

Prostate cancer is sensitive to androgen and hence, this treatment aims to counteract the source and effect of androgen. Contact your physician instantly if you experience allergies, heart problems, falls, fractures or seizures.

Uses of Bdenza 80mg Capsule:

• Treatment of prostate cancer in adult men who have not responded satisfactorily to other anti cancer treatments.

How Bdenza 80mg Capsule Works:

Bdenza 80mg Capsule inhibits the active form of testosterone, called dihydrotestosterone. It selectively blocks the androgen receptors and disrupts the translocation of signals from the receptor to the cell. Thus, the androgen hormone do not bind to the androgen receptors and these androgen receptors do not interact with DNA. This blocks the functioning of cancer cells and reduces its multiplication.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store at 20-25°C in a dry place and keep the container tightly closed. Keep this medicine away from the reach of children

References:

1. Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
2. Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
3. Martín LázaroQuintela et al., Capmide 40mg Tablet: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021], https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
4. Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.

How to use Bdenza 80mg Capsule: 

Swallow Bdenza 80mg Capsule whole with water. This medicine can be taken with or without food.

Safety Advice:

Kidney:

It is not known if dosage adjustment is necessary in patients with severe kidney disease. Consult your physician for advice.

Driving:

Bdenza 80mg Capsule could influence driving and activities that require focus. Consult your physician for advice.

Others:

• Male patients with female partners should use a reliable method of contraception. 
• Bdenza 80mg Capsule might impair fertility. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Hypersensitivity
• Seizures
• Posterior reversible encephalopathy syndrome
• Heart disease
• Falls and fractures

Common:

• Tiredness
• Back pain
• Constipation
• Arthralgia
• Decreased appetite
• Diarrhea
• High BP
• Headache
• Anxiety
• Dry skin
• Enlarged breasts in men
• Inability to concentrate