BIONASE 5K INJECTION
ASPARAGINASE
Manufacturer : ZYDUS CADILAOrigin of Medicine : IndiaIntroduction:
Bionase 5K Injection is a chemotherapy medication containing the active constituent L-asparaginase. It is used to treat Acute Lymphoblastic Leukemia (cancer of white blood cells) in patients aged four months and above. In Acute Lymphoblastic Leukemia, the white blood cells called lymphocytes multiply in an uncontrolled and abnormal manner. This disorder is also known as Acute Lymphocytic Leukemia.
This medicine should not be used if you have severe problems with your pancreas or allergic to any of the ingredients of this medicine. Talk to your physician if you are a diabetic patient as Bionase 5K Injection contains glucose. The common side effects of this medicine are muscle pain, nausea, infections, abdominal pain, and diarrhea.
Use effective birth control during the treatment with Bionase 5K Injection and for at least three months after the last dose. Women should use contraception methods other than oral contraceptives.
Uses of Bionase 5K Injection:
- Acute Lymphoblastic Leukemia (ALL)
How Bionase 5K Injection works:
Cancer cells need a substance called asparagine to survive. Bionase 5K Injection works by lowering the levels of asparagine in the body.
Interactions with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More information:
- Keep Bionase 5K Injection out of sight and reach of children.
- Store in a refrigerator (2°C to 8°C).
References:
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1720.
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 869.
- Porton Biopharma Limited, Electronic medicines compendium (emc), [Revised on June 2021] [ Accessed on 9th August 2021], https://www.medicines.org.uk/emc/files/pil.12340.pdf
- Merck & Co., Inc., US Food and Drug Administration, [Issued on 2000] [ Accessed on 5th August 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/aspamer080102LB.pdf
How to use Bionase 5K Injection:
It will be given to you by your health care professional.
Safety advice:
Pregnancy:
You need to tell your physician if you are pregnant or planning to get pregnant before taking Bionase 5K Injection. it will be given to you if clearly needed.
Breastfeeding:
You must not breastfeed your baby during treatment with Bionase 5K Injection. You need to tell your physician if you are breastfeeding before taking this medicine.
Liver:
You need to tell your physician if you have any liver disorders before taking Bionase 5K Injection.
Kidney:
You need to tell your physician if you have any kidney disorders before taking Bionase 5K Injection.
Driving:
Bionase 5K Injection can cause dizziness and drowsiness. Avoid driving if you are unwell.
Others:
- Talk to your physician if you have severe problems with your pancreas, diabetes, or any allergic conditions before taking Bionase 5K Injection.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Severe allergic reactions
- High blood sugar levels
- Bleeding
- Liver and nervous problems
- Pain near your stomach (inflammation of the pancreas)
- Blood clots in arm or leg
- Pain, bruising, swelling, or hardening of the skin at the injection site
Common:
- Nausea
- Muscle pain
- Weight loss
- Infections (fever, rapid heart rate, confusion, or a rash)
- Difficulty breathing
- Inflammation of the digestive tract
- Diarrhea
- Abdominal pain, discomfort
- Headache
- Tiredness

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