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BONITAR 400MG TABLET_1
BONITAR 400MG TABLET_2
BONITAR 400MG TABLET_3
BONITAR 400MG TABLET_1
12% Off

Bonitar 400mg Tablet

Prescription Required

Salt Composition : Bosutinib

Manufacturer : SUN PHARMACEUTICAL INDUSTRIES LTD

Origin of Medicine : India

MRP: ₹2750
Price : ₹2420
You Save : ₹330 (12%)

10 Tablet(s) In A Strip

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Introduction to Bonitar 400mg Tablet

Bonitar 400mg Tablet contains the active ingredient bosutinib. It belongs to the group of medications called Tyrosine kinase inhibitors. It is indicated to treat adult patients with a type of leukemia known as Philadelphia chromosome-positive (Ph-positive) Chronic Myeloid Leukaemia (CML) who have been newly diagnosed or for whom earlier CML treatments have either failed or have not worked or are not suitable. Philadelphia chromosome-positive chronic myelogenous leukemia is a blood cancer in which the body produces too many of a specific kind of white blood cell called granulocytes. 

 

Low white blood cell count (leukopenia), headache, shortness of breath, joint pain, dizziness, cough, back pain, decreased appetite, respiratory tract infection, raised blood pressure, ringing in the ears (tinnitus), itching, acne, dehydration, taste change, sensitivity to light and fluid on lungs are the common side effects of Bonitar 400mg Tablet. Inform your doctor if any of these symptoms disturb you or persist.

 

Inform your physician if you are allergic to Bonitar 400mg Tablet or its ingredients. Before taking this medication, report to your doctor if you have heart problems, bleeding problems, kidney and liver disorders, infection, or diarrhea. It is not recommended for children under the age of 18. Limit your time outside and use sunscreen if you must go outside, as this medicine can make you more sensitive to the sun or UV rays. 

Uses of Bonitar 400mg Tablet

  • Treatment of Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

Therapeutic Effects of Bonitar 400mg Tablet

Bonitar 400mg Tablet works by inhibiting the activity of an enzyme called Bcr-Abl kinase that promotes the growth and spread of blood cancer (Ph+ CML). This helps to slow or stop the growth and spread of cancer cells.

Interaction of Bonitar 400mg Tablet with other drugs

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information about Bonitar 400mg Tablet

  • Keep Bonitar 400mg Tablet out of sight and reach of children.
  • Store between 20° to 25°C.

How to consume Bonitar 400mg Tablet

Take Bonitar 400mg Tablet in the dose and duration prescribed by your doctor. Take this medicine once a day with food. Swallow it whole and avoid breaking or crushing the tablet. Do not handle or touch the broken tablets. 

Safety Advices for Bonitar 400mg Tablet

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Pregnancy

  

Bonitar 400mg Tablet is unsafe to use during pregnancy as it could cause potential harm to a developing baby. Consult the doctor before taking this medicine, and it will be given to you if clearly needed. Use effective birth control during and for 30 days (one month) after the last dose. 

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Breast Feeding

  

Avoid breastfeeding while taking Bonitar 400mg Tablet, as it is not known whether it passes into the breast milk and harms your baby. Consult the doctor before taking this medication.

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Lungs

  

Inform your doctor if you have any lung conditions before starting treatment with Bonitar 400mg Tablet. 

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Liver

  

Tell your doctor if you have a history of liver problems, including hepatitis, before taking Bonitar 400mg Tablet. Your doctor will perform blood tests to evaluate your liver function.

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Alcohol

  

Drinking a small amount of alcohol does not affect the safety or usefulness of Bonitar 400mg Tablet. As a precautionary measure, limit or avoid alcohol with this medication.

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Driving

  

Taking Bonitar 400mg Tablet can cause dizziness, blurred vision, or unusual tiredness. Do not drive if you feel unwell.

Side Effects of Bonitar 400mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them.

Serious

  • Blood disorders (bleeding, fever, bruising)
  • Stomach problems (stomach pain, vomiting, diarrhea, constipation, nausea)
  • Hepatitis B reactivation
  • Severe skin reactions
  • Liver problems (yellowing of white part of eyes and skin, tea-colored urine)
  • Heart problems (loss of consciousness, irregular heartbeat)

Common 

  • Low white blood cell count (leukopenia)
  • Headache, dizziness
  • Cough, shortness of breath
  • Joint pain, back pain
  • Decreased appetite
  • Respiratory tract infection
  • Increase in blood pressure
  • Ringing in the ears (tinnitus)
  • Itching, acne
  • Dehydration
  • Taste change
  • Sensitivity to light
  • Fluid on lungs

Word of Advice

Women taking Bonitar 400mg Tablet are advised to use effective contraceptives like birth control during treatment and for one month (30 days) after the last dose. Check with your healthcare provider and inform them if you take any other medications, including over-the-counter and prescription medicines, vitamins, and herbal supplements. It is suggested to use sunscreen with a good sun protection factor (SPF) because you are sensitive to sun or UV rays while taking this medication. Do not eat or drink grapefruit-containing food products as this may increase the blood level in your body. 

FAQs

Q 1. Bonitar 400mg Tablet a chemotherapy medication?

Yes, Bonitar 400mg Tablet is a chemotherapy medication that is indicated to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in adults.

Q 2. What class of medication is Bonitar 400mg Tablet?

Bonitar 400mg Tablet belongs to the class of medications called tyrosine kinase inhibitors.

Q 3. Can you crush Bonitar 400mg Tablet ?

No, Bonitar 400mg Tablet should not be crushed or broken. It must be swallowed whole with a glass of water. Do not handle or touch the broken tablets.

Q 4. What is the best time to take Bonitar 400mg Tablet?

It is best to take Bonitar 400mg Tablet once a day without food. Take the tablet at the same time every day for the better results.

Q 5. What happens if I miss my dose of Bonitar 400mg Tablet?

Take the recommended dose if you miss a dose of Bonitar 400mg Tablet by less than 12 hours. If you miss the dose by more than 12 hours, skip the missing dose and start your next dose at the regular time.

Q 6. What should be avoided in Bonitar 400mg Tablet?

Grapefruit, its juices, and supplement that contain grapefruit extract should be avoided during treatment with Bonitar 400mg Tablet as it raises the blood level in your body.

Q 7. Can children use Bonitar 400mg Tablet?

No, Bonitar 400mg Tablet is not recommended for usage in children under 18.

Q 8. Who is contraindicated to take Bonitar 400mg Tablet?

Patients who have experienced allergic reactions (hypersensitivity) to Bonitar 400mg Tablet or have heart or bleeding problems, kidney or liver disorders, and pregnant and breastfeeding women should not use Bonitar 400mg Tablet.

Fact Box of Bonitar 400mg Tablet

Molecule name: Bosutinib 

 

Therapeutic class: Tyrosine kinase inhibitors

Pharmacological class: Antineoplastics

Indications: 

Treatment of Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

References

1. Pfizer Europe MA EEIG, Electronic medicines compendium (EMC), [ Revised on May 2022] [ Accessed on 21 November 2022], https://www.medicines.org.uk/emc/files/pil.3147.pdf 

2. Pfizer, US Food and Drug Administration, [ Revised on April 2017] [ Accessed on 21 November 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/20334s007s008lbl.pdf 

3. Gunhild keller et al; Bosutinib; Recent Results in Cancer Research; Published on 2010; Accessed on 21/11/2022; https://pubmed.ncbi.nlm.nih.gov/20072835/ 
 

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