Bretolap 250mg Tablet contains the active ingredient lapatinib. It is indicated to treat advanced breast cancer, and it may be used alone or in combination with other medications. It is effective against cells sensitive to hormones and rapidly multiplying cancer cells that produce most of the protein called human epidermal growth receptor -2.

The common side effects that are likely to occur while you are on the treatment with Bretolap 250mg Tablet are nausea, vomiting, tiredness, weakness, itching, dry skin, loss of appetite, indigestion, constipation, mouth ulcers, stomach pain, difficulty in sleeping, joint or back pain, cough, breathing problems, headache, etc. If you experience severe allergic reactions, skin rashes, heart, liver, and lung problems, report your physician immediately.

Inform your healthcare provider when you notice any signs of diarrhea or dehydration. Monitor your blood pressure regularly while taking Bretolap 250mg Tablet. If you have diarrhoea while taking this medication, drink plenty of fluids, eat low-fat, high-protein foods, and avoid milk and its products and herbal supplements.

• Treats advanced or HER2 Positive metastatic breast cancer.

Lapatinib acts against the enzyme called tyrosine kinase. It prevents the Human epidermal growth factor receptor protein (HER2) and Epidermal growth factor receptors (EGFRs) from signalling, which are produced by breast cancer cells. It kills cancer cells and slows down their growth. 

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Bretolap 250mg Tablet Injection and cause undesirable side effects.

• Store below 30°C and away from light.

Take Bretolap 250mg Tablet exactly as prescribed by your doctor. Take this medicine at least 1 hour before or after taking the food. Swallow the tablet and do not crush, open, or dissolve them. 

Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them.

Serious

• Diarrhea
• Severe allergic reactions
• Skin rash
• Heart problems

Common

• Loss of appetite
• Nausea, vomiting
• Tiredness, weakness
• Indigestion
• Constipation
• Sore mouth or mouth ulcers
• Stomach pain
• Trouble sleeping
• Back pain
• Pain in the hands and feet
• Joint or back pain
• Cough, breathlessness
• Headache
• Nose bleed
• Hot flush
• Unusual hair loss
• Dry skin and itching

Bretolap 250mg Tablet can cause severe diarrhea, so it is advised to take plenty of water during the treatment. Eat a well-balanced diet. Avoid consuming grapefruit juice while on treatment with Bretolap 250mg Tablet as it affects how the medicine works. This medication makes your skin sensitive to the sun and increases the risk of skin rashes. Avoid spending more time in the sunlight, and ensure that you always apply sunscreen with a good SPF before stepping out. Wash your skin with a soap-free cleanser.

1. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976. 

2. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

3. Novartis Europharm Limited, Electronic medicines compendium (emc), [ Revised on March 2022] [ Accessed on 19th August 2022], https://www.medicines.org.uk/emc/files/pil.6292.pdf

4. GlaxoSmithKline, US Food & Drug Administration, [ Accessed on 19th August 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022059s007lbl.pdf