CANMAB 440MG INJECTION

Introduction:

Canmab 440mg Injection consists of the active ingredient Trastuzumab. It is indicated to treat early-stage and metastatic breast cancer where the cancer cells develop due to overexpression of HER2 proteins. This medication is also used to treat metastatic gastric cancer with increased levels of HER2 proteins. Cancer occurs when the cells begin to grow abnormally and uncontrollably, and cancer that has begun to spread is termed metastatic cancer.

Canmab 440mg Injection is not recommended for patients aged under 18, patients who have severe breathing problems or need oxygen treatment. It is necessary to let your physician know if you have any heart problems, breathlessness, or have ever had any other cancer treatment. Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medication.

Use effective birth control during the treatment and for at least 7 months after the final dose. Suppose you begin any new medication within seven months after the final dose. In that case, you must inform the health care professional that you have had Canmab 440mg Injection as this drug may take around 7 months to be eliminated from the body. 
 

Uses of Canmab 440mg Injection:

Canmab 440mg Injection is indicated to treat the following conditions:

• Early and metastatic breast cancer
• Metastatic gastric cancer

How Canmab 440mg Injection Works:

The substance called HER2 (human epidermal growth factor receptor 2) is found in abundant amounts on surface of certain cancer cells, where it stimulates cancer growth. Canmab 440mg Injection selectively binds to HER2 and stops the growth of cancer cells.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store between 2˚C and 8˚C.

References:

1. Roche, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 28th June 2022],  https://www.medicines.org.uk/emc/files/pil.3856.pdf
2. Genentech Inc, [Revised on Feb 2021] [Accessed on 28th June 2022], https://www.gene.com/download/pdf/herceptin_prescribing.pdf
3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.

How to use Canmab 440mg Injection: 

It will be given to you by your physician. 

Safety Advice: 

Pregnancy:

Discuss with your physician before taking this Canmab 440mg Injection if you are pregnant or think you might be pregnant. Do not take this medicine during the pregnancy unless advised by the doctor to take as it may cause to the unborn baby.

Breastfeeding: 

Do not breastfeed during the treatment and for at least seven months after the final dose. Consult your doctor. 

Liver: 

Discuss with your physician before taking this medicine if you have been diagnosed with liver problems.

Kidney:

Inform your physician before starting this treatment if you have kidney disease. 

Driving:

Do not drive or operate a machine if you experience dizziness, sleepiness or chills until the symptoms subside while taking this medicine.

Others:

Talk with your physician before taking Canmab 440mg Injection if you:

• Have heart problems, high blood pressure, or breathlessness.
• Have ever had any other cancer therapy.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Allergic reactions
• Kidney problems
• Breathing difficulties
• Heart problems

Common:

• Infection
• Diarrhea
• Constipation
• Heartburn
• Tiredness
• Skin rashes
• Pain in the stomach, chest, joints and muscles
• Low blood count
• Fever
• Visual disturbances
• Nose bleeds or runny nose
• Hair loss
• Dizziness
• Nail disorders
• Weight loss
• Loss of appetite
• Sleeplessness
• Bruising
• Breathlessness