CELKERAN 5MG TABLET

Introduction:

Celkeran 5mg Tablet consists of the active ingredient Chlorambucil. It is indicated for cancer and blood-related problems. It is prescribed for Hodgkin’s and non-Hodgkin’s lymphoma, Chronic lymphocytic leukemia and Waldenstrom’s macroglobulinemia.

Hodgkin’s disease and non-hodgkin’s lymphoma are cancers formed in the lymphatic system. Chronic lymphocytic leukemia is a blood cancer where the bone marrow produces abnormal amount of white blood cells. Waldenstrom’s macroglobulinemia is a rare lymphoma that results in the abnormal amount of protein in the blood.

Uses of Celkeran 5mg Tablet:

Celkeran 5mg Tablet is indicated to treat the following conditions:

• Hodgkin’s and non-Hodgkin’s lymphoma
• Chronic lymphocytic leukemia
• Waldenstrom’s macroglobulinemia

How Celkeran 5mg Tablet Works:

Celkeran 5mg Tablet works by lowering the number of abnormal cells produced by the body. It produced cross-linking of the DNA and breaks down the DNA strands. This causes damage to the chromosomes and exerts a toxic effect on the cancer cells, eventually inhibiting tumour growth and multiplication.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store between 2˚C and 8˚C. Protect from light and moisture. 

References:

1. Aspen Pharma Trading Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2017] [Accessed on 13th Apr 2021], https://www.medicines.org.uk/emc/files/pil.4656.pdf
2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

How to use Celkeran 5mg Tablet: 

Take Celkeran 5mg Tablet on an empty stomach. Swallow the tablet whole with a glass of water. Do not crush, break or chew the tablets.

Safety Advice: 

Pregnancy:

Consult your physician before taking this medicine if you are pregnant or think you might be pregnant.

Breastfeeding: 

Talk to your physician before taking this medicine if you are a breastfeeding mother.

Liver: 

Inform your physician before initiating treatment with Chlorambucil if you have liver problems.

Kidney:

Discuss with your physician before taking this medicine if you have kidney problems.

Allergies:

Inform your physician before initiating this regimen if you are allergic to Chlorambucil or any of its ingredients.

Others:

• Inform your physician if you have recently undergone radiotherapy or chemotherapy.
• Discuss with your physician before taking this medicine if you are about to undergo a stem cell transplant.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Fever or infection
• Unusual bleeding or bruising
• Sudden sickness
• Extreme tiredness
• Numbness or weakness of muscles
• Rashes or blisters on skin

Common:

• Decreased levels of blood cell count
• Nausea, vomiting, diarrhea or mouth sores
• Fits
• Secondary blood cancers