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Combither AT 120mg Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Combither AT 120mg Injection
Salt Composition
ARTESUNATEMarketer
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Substitutes
Falcigo 120mg Injection
ZYDUS CADILA
₹ 381.00/injection
33% costlier
Introduction
Combither AT 120mg Injection contains the active component Artesunate, a medication primarily used to treat malaria, especially severe cases caused by Plasmodium falciparum, a parasite responsible for life-threatening complications. It is also used as part of artemisinin-based combination therapies (ACTs) for treating uncomplicated malaria. These therapeutic roles align with common Combither AT 120mg Injection alternatives, as many patients and clinicians compare Artesunate-based therapies within the same treatment category.
Combither AT 120mg Injection may also be used for malaria prevention in regions where the disease is common and drug resistance is not a concern. Some studies suggest potential investigational benefits as an adjunct therapy for certain cancers, and it may help modulate immune responses or reduce inflammation in conditions such as rheumatoid arthritis and inflammatory bowel disease.
Individuals who are hypersensitive or allergic to Combither AT 120mg Injection or other artemisinin derivatives should avoid this medication. It must not be used in individuals with known G6PD deficiency. Caution is advised in patients with liver disease, a history of epilepsy, or other chronic medical issues, and use should be supervised by a healthcare professional. In children and older adults, medical guidance is required due to higher risks of interactions and dosing sensitivity.
When prescribed in an injectable form such as Combither, clinicians determine the appropriate Combither AT 120mg Injection dosage based on severity and patient condition. For cost-related queries, the Combither AT 120mg Injection price may vary depending on region and pharmacy. Patients preferring convenience can opt to Combither AT 120mg Injection buy online from verified medical platforms. If Combither is unavailable or unsuitable, doctors may recommend a Combither AT 120mg Injection substitute that provides equivalent clinical outcomes or explore other Combither AT 120mg Injection alternatives within antimalarial therapy.
Uses
Falcigo 120 mg injection uses:
Malaria treatment
Malaria prevention (in specific cases)
How Combither AT 120mg Injection Works
Falcigo 120 Injection, an antimalarial medication, disrupts the malaria parasite's metabolism within red blood cells. It increases the levels of toxic-free heme, which damages the parasite's cellular components. This disruption leads to oxidative stress and cellular damage, ultimately causing the death of the malaria parasite.
Interaction of Combither AT 120mg Injection with other drugs
Rifampicin (Severe)
Rifampicin may reduce the effectiveness of Combither AT by increasing its metabolism. Avoid this combo unless closely monitored.CYP3A4 Inhibitors / Inducers (Severe)
Strong enzyme modulators like ketoconazole (inhibitor) or carbamazepine (inducer) may alter artesunate levels, leading to toxicity or treatment failure.Antimalarial Drugs (Moderate)
Concurrent use with drugs like chloroquine or atovaquone/proguanil can affect treatment efficacy or increase side effects.Macrolide Antibiotics (Moderate)
Drugs such as erythromycin or azithromycin can interact and may lead to altered artesunate levels.Anti-arrhythmic Drugs (Moderate)
Medicines for rhythm control (e.g., flecainide) may interact when used with Combither AT.Antiepileptics (Moderate)
Drugs like phenytoin and carbamazepine may influence artesunate metabolism, necessitating careful monitoring.
Storage conditions
Store Combither AT 120mg Injection at room temperature, between up to 20°C -25°C
Keep away from moisture, heat, and light.
It should not be frozen.
Keep away from children and pets.
How to Use Combither AT 120mg Injection
Combither AT 120mg Injection can be administered intravenous (IV) for rapid action in severe cases, and intramuscular (IM) as an alternative injection method. The choice depends on the patient's condition and instructions by the health care provider.
Safety Advices
Pregnancy
It is important to discuss your pregnancy status with your healthcare provider before starting Combither AT 120mg Injection, as its safety in pregnancy is not well-established.
Breast Feeding
Combither AT 120mg Injection can be excreted in breast milk. Consult your healthcare provider before breastfeeding while taking this medication.
Lungs
Inform your healthcare provider if you have respiratory symptoms before taking Combither AT 120mg Injection.
Liver
Individuals with severe liver impairment should consult a healthcare provider before taking Combither AT 120mg Injection as liver function can affect the metabolism and elimination of this medication from the body.
Alcohol
Alcohol consumption can cause side effects, so it is unsafe to take alcohol while using this medication.
Driving
It is unsafe to take Combither AT 120mg Injection while driving as it can cause dizziness or drowsiness.
Side Effects
Combither AT 120mg Injection causes some side effects like all medications, although not everyone will experience them. Combither AT 120mg Injection side effects are
Serious side effects of Combither AT 120mg Injection are:
Allergic reactions
Hemolytic anemia
Liver problems
Common side effects of Combither AT 120mg Injection are:
Nausea and vomiting
Headache
Dizziness
Digestive issues
Loss of appetite
Fever
Pain at the injection site
Expert tips
Consult your doctor before starting Combither AT 120mg Injection, especially if you are pregnant, breastfeeding, or have liver or kidney issues.
Inform your doctor about your full medical history, allergies, and other medications.
Watch for serious side effects like allergic reactions or anaemia, particularly if you have G6PD deficiency.
Avoid alcohol, follow the exact prescribed dosage, and complete the full treatment course.
Store the medicine properly and report any adverse reactions immediately; special care is needed for children and older adults.
FAQs
Q1.
Can Combither AT 120mg Injection be taken with food, or should it be taken on an empty stomach?
Follow your healthcare provider's instructions regarding food intake when taking Combither AT 120mg Injection, as it can vary based on the formulation.
Q2.
Can I continue using Combither AT 120mg Injection if I experience mild side effects?
Mild side effects are common and might not warrant discontinuation. Consult your healthcare provider for guidance on managing them.
Q3.
Are there any sun sensitivity concerns with Falcigo 120 Injection uses?
While sun sensitivity is not a common side effect, it's advisable to take precautions against sun exposure while using Combither AT 120mg Injection.
Q4.
Is Combither AT 120mg Injection suitable for individuals with respiratory problems?
Individuals with respiratory issues can use Combither AT 120mg Injection, but informing your healthcare provider about your condition is essential to ensure proper management.
Q5.
Who should avoid using Combither AT 120mg Injection due to certain health conditions?
Individuals with a history of allergies to Combither AT 120mg Injection or related compounds, liver issues, or glucose-6-phosphate dehydrogenase (G6PD) deficiency should use Combither AT 120mg Injection with caution or as directed by a healthcare provider.
Q6.
How long does it usually take for a Combither AT 120mg Injection to start working?
Combither AT 120mg Injection typically acts rapidly, but the exact onset of action can vary. Consult your healthcare provider for information specific to your treatment.
Fact Box
Molecule name | Artesunate |
Therapeutic class | Antimalarial agents |
Pharmacological class | Antimalarial agents |
Indications | 1. Malaria treatment 2. Malaria prevention (in specific cases) |
References
KD Tripathi, Essentials of Medical Pharmacology, Antimalarial drugs, 7th edition, 2013, 829-831.
Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of malaria, 12th edition, 2011, 1396.
Amivas LLC, US Food and Drug Administration, [Revised on May 2020] [ Accessed on 26th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213036s000lbl.pdf
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vikas B S
Pharm D
Reviewed By
Dr. Abhishaanth Prabu
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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