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Comtripsy 20mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
₹3985
MRP: ₹4687.5
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Comtripsy 20mg Tablet
Salt Composition
TRIFLURIDINE AND TIPIRACILMarketer
INTAS PHARMACEUTICALS LTD
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Tipanat 20mg Tablet
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Introduction
Comtripsy 20mg Tablet (also known as Comtripsy 6.14mg/20mg Tablet) is an anticancer medication used to treat colon and rectum cancer that has spread to other parts of the body (metastatic stage). It contains Trifluridine and Tipiracil, where Trifluridine helps slow the growth of cancer cells and Tipiracil ensures it stays active longer in the body. This medicine is not recommended for individuals under 18 years of age.
Do not take Comtripsy 20mg Tablet if you're allergic to its ingredients. Inform your doctor if you have kidney or liver issues, are lactose intolerant, or are pregnant/planning pregnancy. Both men and women should use effective contraception during treatment and for six months after. Common side effects include low white/red blood cell counts and digestive issues. Your doctor may perform regular blood tests and adjust the dose, especially if you have kidney problems.
How to take Comtripsy 20 mg tablet: Usually taken twice a day, in prescribed strength.
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Uses
- Metastatic colorectal cancer
How Comtripsy 20mg Tablet works
Trifluridine interferes with the DNA synthesis of cancer cells and inhibits the growth of cancer cells. Tipiracil stops the body from breaking down Trifluridine and increases its exposure.
Interaction of Comtripsy 20mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications, such as Zidovudine and others, may interact with Comtripsy 20mg Tablet and cause undesirable side effects.
Storage conditions
- Keep Trifluridine & Tipiracil tablet out of sight and reach of children.
- Store at room temperature (20°C - 25°C).
How to take Comtripsy 20mg Tablet
Take Comtripsy 20mg Tablet as advised by your physician. Usually, this medicine will be taken as a whole with a glass of water. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking this medicine if your doctor advises you to stop.
Safety Advice for Comtripsy 20mg Tablet
Breast Feeding
Taking Comtripsy 20mg Tablet while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the treatment. Therefore, talk with your doctor to get more information.
Alcohol
It is unknown whether consuming alcohol while taking a Comtripsy 20mg Tablet is safe. Please speak with your physician.
Liver
Inform your physician if you have liver problems because Comtripsy 20mg Tablet should be used cautiously with this condition.
Lungs
It is unknown whether Comtripsy 20mg Tablet are safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
While taking Comtripsy 20mg Tablet, driving or using machines is unsafe because it may affect your ability to concentrate and react. Talk to your doctor for more information.
Pregnancy
Comtripsy 20mg Tablet are unsafe during pregnancy as they may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment. Use effective contraception.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Comtripsy 20 mg side effects include
Seriou
- Low white blood cell count (fever, chills)
- Anemia (shortness of breath, tiredness)
- Diarrhea, vomiting, abdominal pain
- Unusual bleeding or bruising
- Severe gastrointestinal problem
Common
- Lack of appetite
- Nausea
- Hair loss
- Weight loss
- Changes in taste
- Constipation
- Swelling in hands or feet or mucous membranes
- Mouth pain
- Itchy dry skin
- A lower level of albumin
- Increased bilirubin
- Increase liver enzymes
Expert Tips
-
Inform your doctor if you are intolerant to sugar, as this medicine contains lactose.
-
Dosage may be adjusted if you are an inpatient with a kidney condition.
-
Comtripsy 20mg Tablet is available in two strengths and is usually taken twice daily.
-
Your doctor may recommend a blood test before each dose.
-
Discuss effective contraception methods with your doctor during treatment.
FAQs about Comtripsy 20mg Tablet
Q1.
Who should not take Comtripsy 20mg Tablet?
Comtripsy 20mg Tablet should not be taken by individuals who are allergic to any of its components. It should also be avoided by individuals with severely decreased bone marrow function (reduction in blood count), severe infections, or severe renal or hepatic impairment.
Q2.
Can Comtripsy 20mg Tablet be taken with other medications?
Comtripsy 20mg Tablet may interact with other medications, so it is important to inform your doctor of all the medications, vitamins, and supplements you are currently taking.
Q3.
Can Comtripsy 20mg Tablet affect our immune system?
Comtripsy 20mg Tablet are not known to affect the immune system directly, but they can indirectly affect it by reducing the number of white blood cells (WBC) in the body. This can increase the risk of infections.
Q4.
What should I do if I miss a dose of Comtripsy 20mg Tablet?
If you miss a dose of Comtripsy 20mg Tablet, take it as soon as you remember. Don't double dose to make up for a missed one.
Q5.
At what condition is dose adjustment needed for Comtripsy 20mg Tablet?
If you are a patient with kidney disease, inform your doctor before starting the treatment because adjustment is needed in kidney-conditioned patients.
Fact Box of Comtripsy 20mg Tablet
|
Molecule Name |
Trifluridine and Tipiracil |
|
Therapeutic class |
Antimetabolites |
|
Pharmacological class |
Thymidylate Synthetase Inhibitors |
|
Indications |
Metastatic colorectal cancer |
References
1. Les Laboratories Servier, Electronic medicines compendium (EMC), [Revised on Dec 2020] [Accessed on 25th April 2023], https://www.medicines.org.uk/emc/files/pil.7309.pdf
2.Taiho Oncology, US Food, and Drug Administration, [Revised on Feb 2019] [ Accessed on 25th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/207981s008lbl.pdf
3.Celeste B Burness, Sean T Duggan; Trifluridine/Tipiracil: A Review in Metastatic Colorectal Cancer; Drugs; Published on Sep 2016; Accessed on 03/03/2022; https://pubmed.ncbi.nlm.nih.gov/27568360/
Disclaimer
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Author Details
Written By
Aswini Priya Velmurugan
PG in Biotechnology
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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