Crizalk 250mg capsule contains the active substance Crizotinib. It is an antineoplastic drug that belongs to the class of tyrosine kinase inhibitors. This medicine is prescribed to treat patients with a type of lung cancer called Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) that is locally advanced or metastatic (spread outside the lungs or to other parts of the body). Do not take Crizalk 250mg if you are allergic to Crizotinib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have had kidney, stomach, heart, or liver problems. 

Notify your doctor if you have reduced white blood cells, abnormal heart tracing after ECG, vision problems, or if you take other medications. Report your doctor immediately if you are planning to get pregnant or think you may be pregnant. Talk to your doctor about effective contraceptives. Use effective birth control during the treatment because oral contraception is ineffective with this medicine, and use it at least for 90 days even after completing the therapy with Crizalk 250. It is advised to get suggestions about fertility concerns from your doctor. This medication is not recommended for adolescents and children under 18 years of age. Use sunscreen or protective clothing to cover the skin and protect it against sunburn. Crizalk 250mg price is based on the seller and Place.

Crizalk 250mg uses are:

• Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC)

Crizotinib in Crizalk 250mg by Pfizer is a tyrosine kinase inhibitor that works by blocking the activity of the anaplastic lymphoma kinase (ALK) protein. It specifically targets the abnormal protein and blocks its activity, slowing down or stopping the growth and spread of cancer cells.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications such as Erythromycin, Diltiazem, Verapamil, and other medications may interact with Crizalk 250mg and reduce its effectiveness by causing undesirable side effects. 

• Store at room temperature (15-30˚C) in the original container 
• Keep this medicine out of the sight and reach of children.

Take the Crizalk 250mg capsules at about the same time each day. The recommended dose is one capsule of 250 mg taken orally twice daily. Swallow the capsules whole and do not crush, chew,  dissolve, or open the capsules. Your physician will choose the Crizalk 250mg dosage and administration frequency based on the medical condition because it differs for each person.

Crizalk 250mg side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Crizalk 250mg side effects are:

Serious

• Pain on the right of the stomach
• Partial or full loss of vision
• Lowered WBC
• Low heart rate.
• Swelling of the lungs.
• Breathlessness
• Cough with or without mucus

Common

• Sensitivity to sunlight.
• Diarrhea
• Fever
• Constipation
• Nausea
• Increased liver enzymes
• Decreased appetite  Tiredness (fatigue)
• Dizziness
• Neuropathy (weakness, tingling, or numbness in the nerve)
• Dysgeusia ( taste disorder)
• Hypophosphataemia (low levels of phosphate in the blood)

1. David Eric Gerber, ECOG-ACRIN Cancer Research Group, ClinicalTrials.gov IDNCT02201992 [Accessed on 30th Mar 2021],
2. https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2014-01507&r=1
3. Pfizer, Electronic Medicines Compendium (EMC), [Revised on Jun 2022],  [Accessed on 19th April 2023], ANNEX I (medicines.org.uk)
4. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.