• Prevention of organ rejection (Kidney, liver, and heart)
• Treatment of Rheumatoid arthritis and Psoriasis

By suppressing the immune system, Cyclograf ME 100mg oral solution helps prevent organ rejection in transplant recipients. After organ transplantation, the immune system recognizes the transplanted organ as foreign and launches an immune response to attack and reject it. Cyclograf ME 100mg oral solution inhibits the activation of T-cells, a type of white blood cell involved in immune responses. This suppression of T-cell activity helps to prevent the immune system from attacking and damaging the transplanted organ, thereby increasing the chances of successful organ transplantation.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Cyclograf ME 100mg oral solution and reduce its effectiveness by causing undesirable side effects.

• Store this medication below 30°C
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• Take only a partial dose to make up for a forgotten dose.

Cyclograf ME 100mg is a oral solution used under a physician's prescription. The frequency and duration of its use will be determined by your doctor, taking into account your specific disease condition and other relevant factors. It is essential to follow your doctor's instructions precisely and not to misuse or overuse this solution.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious 

• Kidney damage
• Liver damage
• Infection, fever or sore throat
• Lack of coordination
• Memory problems
• Difficulty in speaking
• Visual problems
• Seizures
• Confusion
• Personality changes
• Sleeplessness
• Agitation

Common 

• Hypertension
• Electrolyte imbalance
• Increased level of potassium in the blood
• Tremor
• Abnormal hair growth
• Enlargement of gum tissues
• Low levels of magnesium
• Risk of infections
• Headache
• Gastrointestinal disturbances

When using Cyclograf ME 100mg oral solution, it is important to take several precautions. These include monitoring infections, kidney and liver function, blood pressure, and neurological symptoms closely. Abruptly stopping this medication can increase the risk of rejection in organ transplant patients or worsening autoimmune conditions. Pregnant and breastfeeding women should consult a doctor before taking it. Regular skin examinations and vigilance for signs of malignancies are advised. Allergic reactions should be promptly addressed. Awareness of potential drug interactions and gastrointestinal side effects is crucial. Regular blood tests to monitor blood cell counts and electrolyte levels are essential. Diabetes monitoring is important, especially for individuals at risk. Pediatric and geriatric patients require special consideration. Psychological effects should be monitored, and close consultation with healthcare professionals is necessary to ensure safe and effective use of it.

1. Novartis, US Food and Drug Administration, [Revised on Sep 2009] [Accessed on 25th May,  2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050715s027,050716s028lbl.pdf
2. Novartis Pharmaceuticals UK Limited, Electronic Medicines Compendium (EMC), [Revised on March 2023] [Accessed on 25th May 2023],  https://www.medicines.org.uk/emc/files/pil.1034.pdf
3. KD Tripathi, Immunosuppressant Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019,.937-945.