CYCLOXAN 500MG INJECTION

Introduction:

Cycloxan 500mg Injection is a chemotherapy drug containing the active constituent cyclophosphamide. It is used to treat various malignancies (abnormal production of cells is called cancer; if they spread, those are called malignancies). Cycloxan 500mg Injection can be used to treat malignant lymphomas (cancers that start from the lymphatic system of the body- vessels, fluid, and lymphoid tissue) such as Hodgkin’s disease, lymphocytic lymphoma, and mixed-cell type lymphoma. 

It is used to treat leukemias, neuroblastoma, ovarian cancer, retinoblastoma, and breast carcinoma. It can also be used to treat Minimal Change Nephrotic syndrome in pediatric patients (kidney disease in which large quantities of protein are lost in urine). Cycloxan 500mg Injection is contraindicated in pregnancy, patients with acute infections, urinary tract infections, urinary outflow obstruction, and bone marrow disorders. 

Treatment with Cycloxan 500mg Injection may lead to immune suppression, bone marrow failure, cardiotoxicity, renal toxicity, pulmonary toxicity, and secondary malignancies. Inform your doctor if you have pre-existing kidney disease, immune conditions, cardiac disorders, or liver diseases.

Uses of Cycloxan 500mg Injection:

• Malignant lymphomas
• Leukemias
• Retinoblastoma
• Carcinoma of breast
• Ovarian cancer
• Mycosis fungoides
• Minimal Change Nephrotic Syndrome in Pediatric Patients

How Cycloxan 500mg Injection works:

Cycloxan 500mg Injection slows or stops the growth of cancer cells by damaging the hereditary material (DNA and RNA) of the cancer cells. In nephrotic syndrome, it works by suppressing the body’s immune system.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Cycloxan 500mg Injection out of sight and reach of children.
• Store vials below or at 25°C.

References:

1. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 860.
2. Baxter, Electronic medicines compendium (emc), [ Revised on June 2016] [ Accessed on 8th April 2021], https://www.medicines.org.uk/emc/product/1815/smpc
3. Baxter, US Food and Drug Administration, [ Revised on May 2013] [ Accessed on 7th April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/...

How to use Cycloxan 500mg Injection:

It will be administered intravenously by physicians who are experienced in cancer chemotherapy. 

Safety advice:

Pregnancy: 

Cycloxan 500mg Injection can cause fetal harm when administered to the pregnant woman. Inform your physician if you are pregnant or planning to get pregnant before taking this medication. Your physician will instruct you to take when it is necessary.

Breastfeeding:

Avoid this medication if you are breastfeeding. Consult your doctor for potential risks and benefits.

Liver:

Inform your doctor if you have any liver disorders.

Kidney:

Inform your doctor if you have any chronic kidney diseases. 

Driving: 

The patient undergoing treatment with this medicine may have dizziness, blurred vision. Consult your doctor before driving and handling heavy machines.

Others:

• Inform your doctor about if you have any heart or bone marrow disorders. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Infections
• Immune suppression
• Blood disorders
• Allergic reactions
• Abnormal liver function
• Inflammation of the bladder
• Kidney diseases
• Blood in urine
• Sterility
• Impaired wound healing

Common:

• Nausea, vomiting
• Low white blood cell count
• Diarrhea
• Hair loss
• Fever
• Weakness
• Inflammation
• Dizziness
• Blurred vision
• Amenorrhea