Damir Tablet is a nutrient supplement with an active ingredient called Alpha Ketoanalogue. It belongs to the class of medicine called amino acids. It is given along with a protein-restricted diet to delay the progression of chronic kidney disease (CKD). It reduces uraemic symptoms (caused by the accumulation of nitrogenous waste compounds normally eliminated by the kidneys), improves nutritional status, and reduces metabolic complications in CKD patients. It works by lowering urea levels in the bloodstream and slowing down the advancement of kidney disease, thereby delaying the need for long-term dialysis.

Do not consume Damir Tablet if you are allergic to Alpha Ketoanalogue or any of its ingredients. Avoid consuming this medicine if you have hypercalcemia (high level of calcium) or abnormal heartbeats; because the administration of this medicine may cause increased calcium levels in the blood and irregular heartbeats. During treatment, your doctor may recommend periodic monitoring of your serum calcium levels. Notifying your doctor if you are pregnant and breastfeeding before taking this medicine. Damir Tablet substitute include Domstal, Vomistop, Motilium, and other brands containing domperidone 10 mg. Damir Tablet price in India varies by retailer and location. You can buy Damir Tablet online.

Damir Tablet uses are:

• Treatment of Chronic kidney disease

• Delaying disease progression and the onset of dialysis

• Reducing metabolic complications due to renal insufficiency

• Reduction of uraemic symptoms

Damir Tablet is classified as a nutritional supplement that operates through comparable catabolic pathways to amino acids. Enhanced protein metabolism promotes improved renal function, thereby delaying the progression of chronic kidney disease. Additionally, it ensures the intake of essential amino acids.

1. Ketoconazole / Itraconazole (Severe)
   These antifungals can sharply increase domperidone levels, raising the risk of dangerous heart rhythm disturbances. This combination should be avoided.

2. Erythromycin / Clarithromycin (Severe)
   Macrolide antibiotics may heighten domperidone’s QT-prolonging effect, increasing the chance of arrhythmias. Use only under strict medical supervision.

3. Antiarrhythmics like Amiodarone or Sotalol (Severe)
   These medicines can add to domperidone’s cardiac risks, especially QT prolongation. Doctors generally avoid using them together.

4. Fluconazole (Moderate)
   Fluconazole may raise domperidone levels in the blood, increasing side effect potential. Dose adjustment or monitoring may be needed.

5. Antipsychotics (Moderate)
   Drugs such as haloperidol or quetiapine may further increase the risk of heart rhythm changes. ECG monitoring is recommended when used together.

6. Opioid Pain Medicines (Mild)
   Opioids may increase dizziness or sedation when combined with domperidone. Caution is advised during activities requiring alertness.

• Keep out of sight and reach of pets and children.

• Do not freeze the medicine.

• Do not store above 30°C.

• Always check the expiry date before consuming it.

Take the Damir Tablet as your physician advises. Usually, the tablets will be taken with or without food. Do not crush, chew, or open the medicine. Your physician will decide the correct Damir Tablet dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Damir Tablet side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Common

• Increased calcium level in the blood

• Take Damir Tablet exactly as prescribed by your doctor—don’t change the dose on your own.

• Inform your doctor about any kidney problems or other health conditions before starting the medicine.

• Do not take a double dose if you miss one; just take the next dose at the usual time.

• Watch for unusual symptoms or side effects and report them to your doctor promptly.

• Do not stop the tablet suddenly unless your doctor advises you to.

1. Rivpra formulation PVT LTD, [ Revised on Jan 2021] [Accessed on 15th June 2023], https://www.centaurpharma.com/downloads/2021/nephrology/NEFROGARD.pdf

2. Alexander Zemchenkov, Irina N.Konakova; Efficacy of the Essential Amino Acids and Keto-Analogues on the CKD progression rate in real practice in Russia - city nephrology registry data for outpatient clinic; BMC Nephrology; [Published on 07/07/2016]; [Accessed on 15th June 2023] https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-016-0281-z

3. Arun Sharma et al; Rationale of α-Ketoanalogue Supplemented with Low Protein Diet for the Treatment of Chronic Kidney Disease; Journal of Karnali Academy of Health Sciences; [Published on 09/01/2021]; [Accessed on 15th June 2023]; https://jkahs.org.np/jkahs/index.php/jkahs/article/view/415/222

4. Che-Hsiung Wu et al; Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease; [Published on 05/05/2021]; [Accessed on 15th June 2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5419544/