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Dasanat 20mg Tablet
Last updated on 31 Mar 2026 | 09:31 AM (IST)
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Introduction
Dasanat 20mg tablet consists of the active ingredient Dasatinib. It is prescribed for adults and children above one year of age with Chronic Myeloid Leukemia (CML). This medicine is used to treat newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia in the chronic phase and Ph+ acute lymphoblastic leukemia (ALL) in patients resistant to other therapies. Chronic Myeloid Leukemia refers to a type of blood cancer that causes the body to produce too many white blood cells due to alterations in the Philadelphia chromosome. Acute Lymphoblastic Leukemia is the most common form of blood cancer affecting children, where lymphocytes multiply too quickly and live too long. These conditions form the major Dasanat 20mg uses.
Patients often check the Dasanat 20mg price before beginning therapy, and costs may vary depending on pharmacy and manufacturer. For those comparing treatment options, Dasanat 20mg vs Sprycel (both containing Dasatinib) is a common search, as Sprycel is another well-known brand of the same medication. If needed, your doctor may also suggest Dasanat 20mg substitutes depending on availability and treatment response. Many patients prefer convenience and choose to buy Dasanat 20mg online, provided it is from a trusted and legal pharmacy. The product is generally available as a Dasanat 20mg tablet 1mg strength equivalent per active dose, manufactured by approved pharmaceutical companies; specific Dasanat 20mg manufacturer details can vary based on the brand.
The common Dasanat 20mg side effects include diarrhea, headache, cough, rash, nausea, tiredness, vomiting, muscle pain, weakness, low appetite, and fluctuations in blood pressure. One of the important safety considerations is Dasanat 20mg and pleural effusion, as Dasatinib is known to cause fluid accumulation around the lungs in some patients. Inform your doctor immediately if you notice trouble breathing, chest tightness, or persistent cough. Inform your doctor if these or any other side effects disturb or persist you.
Inform your doctor if you are allergic to Dasatinib or any of its ingredients. Before starting treatment with this medication, you should let your physician know if you have liver or heart problems, breathing difficulties, chest pain, cough, hepatitis B infection, or bleeding issues. This medicine could cause a severe reduction in the number of platelets, WBC, or RBC in the blood, so your physician will monitor your blood levels regularly. Tell your healthcare professional about all the medicines you take, including prescription drugs, OTC medicines, vitamins, antacids, and herbal supplements. It is not recommended for children below one year of age. Your doctor will also guide you on how to take Dasanat 20mg tablet safely, usually swallowed whole with water and taken at the same time each day.
Uses
DasanatĀ 20mgĀ tablet is indicated for the following conditions
Children and adults with chronic myeloid leukemia.
Adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance to prior therapy.
How Dasanat 20mg Tablet Works
DasanatĀ 20mgĀ tablet works by preventing the abnormal protein from signaling the growth of cancer cells. This aids in preventing or reducing the spread of cancer cells.
Interaction of Dasanat 20mg Tablet with other drugs
1. Antacids & Acid-Reducing Medicines
Antacids, H2 blockers (Ranitidine), and PPIs (Omeprazole, Pantoprazole) reduce Dasanat absorption.
Should be avoided or spaced several hours apart.
2. Antifungal & Antibiotic Medicines
Ketoconazole, Itraconazole, Clarithromycin, and Erythromycin increase Dasatinib levels.
May cause severe side effects such as low blood counts and fluid retention.
3. Anticonvulsants (Seizure Medicines)
Carbamazepine, Phenytoin, and Phenobarbital reduce Dasanat effectiveness by lowering drug levels.
Dose adjustments may be required.
4. HIV Medicines
Ritonavir, Saquinavir, and other protease inhibitors can significantly increase Dasanat concentration.
Close monitoring is essential.
5. Blood Thinners
Warfarin, Heparin, and antiplatelet drugs like Aspirin or Clopidogrel increase bleeding risk.
Use with caution under medical supervision.
6. Heart Rhythm Medicines
Amiodarone, Quinidine, and Sotalol may increase the risk of heart rhythm problems (QT prolongation).
Regular ECG monitoring may be needed.
7. Immunosuppressants
Cyclosporine and Tacrolimus may increase the risk of toxicity or drug interactions.
Doctor monitoring is essential.
8. Other Cancer Medicines
Strong CYP3A4 inhibitors or inducers may alter Dasanat 20mg levels, affecting treatment response.
Dose changes may be necessary.
9. Herbal Supplements
St. Johnās Wort lowers Dasatinib levels and reduces treatment effectiveness.
Should be completely avoided.
Storage Condition
Store protected from light at a temperature not exceeding 30c.
How to Use Dasanat 20mg Tablet
Take the tablet with or without food at the same time each day. Do not break, crush or chew the tablet. Your doctor will decide the dose and frequency of DasanatĀ 20mgĀ tablet administration based on your disease severity and other factors. Do not stop taking the tablet without consulting your healthcare professional.Ā
Safety Advice
Breast Feeding
It is not recommended to breastfeed while taking DasanatĀ 20mgĀ tablet as it is unknown whether this medication passes into breast milk. You should not breastfeed during treatment and for 2 weeks after your final dose.
Alcohol
It is not known whether it is safe to consume alcohol with DasanatĀ 20mgĀ tablet. Consult your doctor for advice.
Liver
Inform your physician before starting this treatment if you have liver diseases. Your physician will prescribe a dose accordingly.
Lungs
It is unknown whether DasanatĀ is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment.
Driving
Avoid driving or using machinery if you experience symptoms like breathlessness or altered consciousness.
Pregnancy
DasanatĀ 20mgĀ tablet is not recommended during pregnancy unless necessary. Your physician will discuss the potential risk during pregnancy. Women should use effective birth control during treatment and 30 days after the final dose.Ā
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Ā
Serious
Unusual bleeding or bruising
Rapid heart rate
Changes in consciousness or speech
Breathlessness and swelling all over the body
Fever or signs of infection
Fluid retention
Heart problems
Myelosuppression
Severe allergic reaction
Common
Diarrhea
Headache
Cough
Rash
Nausea, tiredness, vomiting
Muscle pain, weakness
Low appetite
High or low BP
Expert Tips
Use effective contraception during treatment and for 30 days after the last dose (for both men and women).
Monitor your blood pressure regularly while taking Dasanat 20mg Tablet.
Inform your doctor immediately if you notice blood in urine or stools, as it may indicate bleeding complications.
If you are using antacid medication, take it 2 hours before or 2 hours after taking Dasanat 20mg Tablet to avoid reduced absorption.
Frequently Asked Questions
Q1.
Can children use DasanatĀ 20mgĀ tablet?
DasanatĀ 20mgĀ tablet is not recommended for children under the age of one.Ā
Q2.
Can DasanatĀ 20mgĀ tablet cause hair loss?
Yes, Hair loss is one of the common side effects of taking Dosatinib. Consult your doctor for advice if these side effects disturb or persist.Ā
Q3.
Is DasanatĀ 20mgĀ tablet a chemotherapy drug?
Yes, DasanatĀ 20mgĀ tablet is a chemotherapy medication that belongs to the group of Tyrosine kinase inhibitors.Ā
Q4.
Should DasanatĀ 20mgĀ tablet be taken with food?
Yes, DasanatĀ 20mgĀ tablet can be taken with or without food. Do not take this medication with grape fruit and its juices.Ā
Q5.
Which population is contraindicated from taking DasanatĀ 20mgĀ tablet?
DasanatĀ 20mgĀ tablet is contraindicated for pregnant and breastfeeding women and children whose age below one year. It is not recommended if you are allergic to Dasatinib and its ingredients.
Fact Box
Molecule name:Ā | Dasatinib |
Therapeutic class:Ā | Anti-neoplastics |
Pharmacological class:Ā | Tyrosine kinase inhibitor |
Indications:Ā | 1. Myeloid leukemiaĀ 2. Philadelphia chromosome-positive acute lymphoblastic leukemiaĀ |
References
- Bristol-Myers Squibb Pharma, Electronic Medicines Compendium (EMC), [Revised on Mar 2022] [Accessed on 1st Dec 2022], https://www.medicines.org.uk/emc/files/pil.7745.pdf
- Bristol-Myers Squibb Company, [Revised on Jun 2021] [Accessed on 1st Dec 2022], https://packageinserts.bms.com/ppi/ppi_sprycel.pdf
- H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidsonās Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056.
- Edward Chu, Cancer Chemotherapy, Langeās Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Disclaimer
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Author Details
Written By
Dr Rakshitha B K
Doctor of Pharmacy
Reviewed By
Dr. Abhishaanth Prabu
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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