ENFIERA 100MG INJECTION

Introduction:

Enfiera 100mg Injection consists of the active ingredient Rituximab. It is prescribed to treat lymph node disease, Chronic Lymphocytic Leukemia, Rheumatoid Arthritis, Pemphigus Vulgaris and granulomatosis with polyangiitis. Non-Hodgkin's Lymphoma is a disease of the lymph tissue that affects the white blood cells. Chronic Lymphocytic Leukemia is the accumulation of abnormal lymphocytes, a type of white blood cells in the bone marrow and blood. Rheumatoid arthritis is a persistent inflammatory disease of the joints.

Granulomatosis with polyangiitis and microscopic polyangiitis are inflammatory disorders of the blood vessels that affect the lungs and kidneys. Pemphigus Vulgaris is an autoimmune disorder affecting the skin, the lining of the mouth, throat and genitals.

Uses of Enfiera 100mg Injection:

• Management of Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
• Treatment of Rheumatoid arthritis, Pemphigus Vulgaris and granulomatosis.

How Enfiera 100mg Injection works:

Enfiera 100mg Injection acts against the CD20 receptor expressed by the immature plasma cells and the B lymphocytes of the white blood cells. It depletes B cells through stimulation of cell toxicity. This process inhibits the action of cells that are responsible for inflammation and prevents the growth and multiplication of tumour cells.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store in a refrigerator (2-8°C) and keep the injection out of the sight and reach of children

References:

1. S.H. Ralston, I.B. McInnes, Rheumatology and Bone Disease, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 1057-1135.
2. Ahmed A. Negm & Daniel E. Furst, Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 642-666.
3. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Aug 2021] [Accessed on 20th Dec 2021], https://www.medicines.org.uk/emc/files/pil.3801.pdf

How to use Enfiera 100mg Injection: 

Your physician will administer this injection intravenously and monitor you constantly.

Safety Advice:

Pregnancy:

Tell your physician if you are pregnant, think you might be pregnant or planning to become pregnant before taking this medicine.

Breastfeeding: 

Breastfeeding during this treatment may not be safe. Your physician might suggest you to stop breastfeeding for some time depending on your condition.

Liver:

Inform your physician before starting this treatment if you have hepatitis or other liver diseases. 

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.

Others:

• Inform your physician before starting this treatment if you have severe infection, weak immune system, severe heart failure or heart disease.
• Talk to your physician if you are about to take vaccination in the near future.
• Inform your physician if you experience allergic reactions to Rituximab or its ingredients.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Infection
• Skin reactions
• Allergic reactions
• Heart problems

Common:

• Infusion related reactions
• Low levels of RBC, WBC or platelets in blood
• Bald spots, headache
• Nausea
• Low immunity
• High levels of glucose and LDL in the blood
• Swelling of the face
• Restlessness
• Tinnitus
• Dizziness and anxiety
• Wheezing
• Muscle problems