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Graftide S 360mg Tablet
Prescription Required
Salt Composition : Mycophenolate Sodium
Manufacturer : MYLAN PHARMACEUTICALS PVT LTD
Origin of Medicine : India
10 Tablet(s) In A Strip
Introduction to Graftide S 360mg Tablet
Graftide S 360mg tablet is an immunosuppressant with an active ingredient called Mycophenolate sodium. It belongs to the inosine monophosphate dehydrogenase (IMPDH) inhibitor category. This medicine is used to prevent organ rejection in individuals who have previously received an organ transplant (such as kidney, heart, or liver transplantation). It is prescribed as part of a combination therapy that includes other immunosuppressive drugs.
This drug is contraindicated during pregnancy due to the risk of birth defects and miscarriage. It should not be advised in pregnant women unless there are no relevant alternatives and the potential benefits outweigh the risks. Female patients with reproductive potential are highly advised to use effective contraception while taking this tablet to prevent pregnancy. Live vaccines should not be administered while a person is taking Graftide S 360mg tablet due to reduced vaccine effectiveness and the risk of infection.
Individuals taking this drug should not donate blood during treatment and at least six weeks after stopping treatment. It ensures that the medication has been adequately cleared from the body before donating blood.
It is generally advised not to take this medicine if you are allergic to the drug or any other ingredients. Inform your doctor if you have liver or heart disease before initiating the treatment. As this drug reduces the body's immune defences, it can increase the chance of skin cancer. Individuals must take precautions to limit their exposure to sunlight and ultraviolet (UV) light.
Seek your doctor immediately if you develop any bruising under the skin, fever, unexplained tiredness, dizziness, yellowing of the skin or eyes, vision impairment, reduced urine output, or seizures after taking this medicine. Graftide S 360mg tablet is an immunosuppressive medication. It may affect the infant's developing immune system and should be avoided when breastfeeding.
Uses of Graftide S 360mg Tablet
Graftide S 360mg Tablet is used in the treatment of the following:
- Prevent organ transplant rejections.
Therapeutic Effects of Graftide S 360mg Tablet
Graftide S 360mg tablet works by inhibiting the enzyme inosine monophosphate dehydrogenase (IMPDH) and reducing the production of guanosine nucleotides. MMF specifically affects the proliferation of activated T and B lymphocytes. These lymphocytes are key players in the immune response that can lead to the rejection of a transplanted organ.
Interaction of Graftide S 360mg Tablet with other drugs
Inform your doctor about all your medicines, such as over-the-counter medications, prescription medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain groups of medications may interact with the effects of Graftide S 360mg tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Graftide S 360mg Tablet
- Store Graftide S 360mg tablet at room temperature between (15°C to 30°C)
- Keep the medicine away from the reach of children and pets.
How to consume Graftide S 360mg Tablet
It is an orally available prescription drug. Your physician will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Always take Graftide S 360mg tablet as prescribed by your doctor. Do not open, crush, break, or chew the medicine. Take the medicine at the same time every day as advised by your doctor.
Safety Advices for Graftide S 360mg Tablet
Pregnancy
Graftide S 360mg tablet is known to have harmful effects on the developing fetus and is generally not taken during pregnancy unless your doctor prescribes the medicine.
Breast Feeding
Graftide S 360mg tablet is not recommended for breastfeeding mothers because small amounts of the drug can pass into the mother's milk and affect the nursing baby.
Lungs
It is generally considered safe for individuals with liver disease; however, inform your physician if you have any liver diseases.
Liver
Graftide S 360mg tablet should be cautiously administered in patients with lung diseases. Dose adjustments are necessary. Inform your physician if you have lung problems before initiating the therapy.
Alcohol
It is unsafe to consume alcohol when taking Graftide S 360mg tablet because it may cause excessive drowsiness or liver problems.
Driving
Driving vehicles or operating machinery while taking Graftide S 360mg tablet is unsafe because it may cause drowsiness and vision problems.
Side Effects of Graftide S 360mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Graftide S 360mg Tablet include:
- Infections, fever, or sore throat
- Unusual bleeding or bruising
- Low blood cell count
- Severe allergic reactions
Common side effects of Graftide S 360mg Tablet include:
- Higher risk of developing lymphoma and other cancers
- Nausea, abdominal pain
- Diarrhea
- Constipation
- Loss of appetite
- Shortness of breath
- Weight loss
- Increased heartbeat
- Headache
- Blood pressure problem
- Anaemia
Word of Advice
It is necessary to take the prescribed dose exactly as instructed by your doctor. Inform your doctor about all the medications (prescription, over-the-counter, and herbal) you are taking, as they can interact with this drug. If you plan to conceive or suspect you might be pregnant while taking Graftide S 360mg tablet, it is important to consult your doctor immediately. They may suggest switching to alternative medications that are safer during pregnancy or adjusting your treatment plan.
FAQs
Q 1. Can I breastfeed while taking Graftide S 360mg tablet?
Breastfeeding is generally not recommended while taking Graftide S 360mg tablet. This drug can pass into the mother's breast milk and may hurt the nursing infant. Consult your doctor about breastfeeding if you are taking this tablet.
Q 2. How does Graftide S 360mg tablet work?
Graftide S 360mg tablet suppresses the immune system, preventing it from attacking the transplanted organ. It inhibits the activity of certain immune cells involved in the rejection process.
Q 3. What will happen if I stop taking Graftide S 360mg tablet suddenly?
Stopping your treatment all of a sudden may cause your condition to become worse. Do not stop taking Graftide S 360mg tablet without consulting your doctor.
Q 4. How should I take Graftide S 360mg tablet?
Follow the instructions advised by your doctor or the medication label. Graftide S 360mg tablet is taken orally with food to improve absorption. It should be swallowed, not chewed or broken.
Q 5. Can I drink alcohol while taking Graftide S 360mg tablet?
It is highly recommended to limit or avoid alcohol consumption while taking Graftide S 360mg tablet. Alcohol can interact with the medication, increasing the risk of side effects or interfering with its effectiveness.
Q 6. Whether Graftide S 360mg tablet can cause miscarriage?
Yes, Graftide S 360mg tablet can cause miscarriage. If you have childbearing potential, use effective contraception before or during treatment and at least six weeks after discontinuing the medication. Discuss contraceptive options with your doctor properly.
Q 7. Can I get vaccinated during the treatment with Graftide S 360mg tablet?
Live vaccines should be avoided while taking Graftide S 360mg tablet due to the risk of infection. Inform your healthcare provider about your immunization history and consult them regarding the appropriate timing of vaccinations.
Fact Box of Graftide S 360mg Tablet
Molecule name: Mycophenolate sodium | Therapeutic class: Immunosuppressants |
Pharmacological class: Inosine monophosphate dehydrogenase (IMPDH) inhibitor | Indications: Prevent organ transplant rejections |
References
- Novartis Ireland Limited, European Medicine Consortium (EMC), [Revised on Nov 2022], [Accessed on 25/05/2023], https://www.medicines.org.uk/emc/files/pil.5560.pdf
- S.E. Marshall, Immunological Factors in Disease, Davidson's Principles and Practice of Medicine, 22nd Edition, 2014, 71-96.
- KD Tripathi, Immunosuppressant Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019,.937-945.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Inflammation, Immunomodulation, and Hematopoiesis, 12th Edition, 2011, 1014.
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