Isentress 400mg Tablet is approved for the following uses:

• Treatment of HIV-1 infection in adults and children (aged 4 weeks and older and weighing at least 3 kg)
• Used as part of a combination therapy for managing HIV infection

Raltegravir works by blocking an enzyme called integrase, which the HIV virus needs to multiply and spread in the body. Without this enzyme, the virus cannot insert its genetic material into healthy cells, making it harder for the infection to grow. This helps to reduce the amount of HIV in the body and allows the immune system to function more effectively. While it does not cure HIV, it helps control the infection when taken regularly with other medications.

Isentress 400mg Tablet may interact with other medicines, leading to serious side effects or reduced effectiveness. It’s important to inform your doctor about all the medications, supplements, or herbal products you are taking before starting this medicine.

• Antacids containing aluminium or magnesium can reduce the absorption of Raltegravir. These should be taken several hours apart.
• Rifampin, an antibiotic used to treat tuberculosis, may lower the effectiveness of Raltegravir and should be avoided unless absolutely necessary.
• Phenytoin and phenobarbital, used to treat seizures, may affect how Raltegravir works.
• Warfarin (blood thinner) may require closer monitoring as Raltegravir can alter its effects.
• Statins such as simvastatin and lovastatin may increase the risk of muscle problems when used with Raltegravir.
• Do not take Raltegravir with products containing St. John’s Wort as it can reduce the drug’s effectiveness.

Always check with your doctor or pharmacist before adding or stopping any medicine.

• Store at room temperature, away from moisture and heat.
• If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed one.
• Do not double the dose to make up for a missed one.
• In case of overdose, seek medical attention immediately, even if you feel fine.
• Keep this medicine out of reach of children and do not share it with others.

Isentress 400mg Tablet is usually taken in the form of tablets or chewable tablets. The standard dose for adults is 400 mg taken twice daily, with or without food. It should be swallowed whole with a glass of water. Do not crush or chew the film-coated tablets. Always follow your doctor’s exact instructions regarding dosage and duration of treatment.

Common side effects:

• Headache
• Trouble sleeping
• Nausea
• Dizziness
• Tiredness
• Diarrhea

Serious side effects:

• Severe muscle pain or weakness (possible sign of muscle damage)
• Allergic reactions like rash, swelling, or difficulty breathing
• Liver problems (yellowing of the skin or eyes, dark urine)
• Depression or mood changes

Seek immediate medical attention if serious side effects occur.

Isentress 400mg Tablet is most effective when taken consistently and as prescribed. Skipping doses or stopping the medicine without your doctor’s advice can lead to the virus becoming resistant, making treatment harder. Make sure to attend all scheduled follow-ups and routine lab tests to monitor how well the treatment is working. Avoid sharing personal items like razors or toothbrushes, and always use protection during sexual activity to prevent spreading the virus to others.

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022145s029lbl.pdf
2. https://www.ema.europa.eu/en/medicines/human/EPAR/isentress
3. https://clinicalinfo.hiv.gov/en/drugs/raltegravir/fda-label
4. https://clinicalinfo.hiv.gov/en/guidelines/pediatric-arv/raltegravir