Izirize Injection 1.5ml is a medicine containing Inclisiran as an active ingredient which belongs to the class of medications called proprotein convertase subtilisin kexin type-9 [PCSK-9]. It is first in class and only small interfering RNA (siRNA) therapy to lower low-density lipoprotein cholesterol. It is used to lower the level of low density lipoprotein. It is prescribed as a complement to statin medication and diet in the management of patients with primary high cholesterol levels. 

It is not recommended to use this medication if you are allergic to the active compound Izirize Injection 1.5ml or its components. It is not recommended to use during pregnancy and breastfeeding; it is advised to consult your physician regarding further queries. It is not recommended for children and adolescents under the age of 18. You should be taking a statin and following a diet to reduce your cholesterol before beginning this therapy. For the duration that you are receiving Izirize Injection 1.5ml, you should continue taking the statin and adhering to this cholesterol-lowering diet. Do not stop taking this medicine without consulting your doctor. Talk to your doctor if you have kidney disorders, breathing problems, liver disorders, heart problems, or intolerance to sugars before taking this medicine. Inform your physician or pharmacist of any additional medications you are taking, have recently taken, or may take, including over-the-counter medications and herbal remedies. Izirize injection price varies on retailer and location.

Combination to other statin therapy and diet for treating primary hyperlipidemia [heterozygous familial hypercholesterolemia].

Izirize Injection 1.5ml is a small interfering RNA (siRNA) molecule that interferes with the production of PCSK9 protein in the liver. By inhibiting PCSK9 synthesis, Izirize Injection 1.5ml increases the number of LDL receptors on liver cells, promoting the clearance of LDL cholesterol from the blood. This mechanism ultimately leads to lower LDL cholesterol levels in the bloodstream, helping to reduce the risk of cardiovascular events such as heart attack and stroke.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Izirize Injection 1.5ml and reduce its effectiveness by causing undesirable side effects.

• Izirize Injection 1.5ml should be stored at room temperature, between 20°C to 25°C (68°F to 77°F).

• Protected from light.

• Keep it in its original packaging until it is ready to be used.

• Keep out of the reach of children and pets.

• Should be disposed of properly.

Izirize Injection 1.5ml will be administered to you by a healthcare professional in a hospital setting. It is usually administered as a subcutaneous injection into the abdomen, upper arm, or thigh. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors. The second dose is given after 3 months and the subsequent dose every 6 months.

Like all medications, Izirize Injection 1.5ml can cause side effects, although not everyone who takes it will experience them. 

Common:

• Injection site reactions like redness, rash and pain

• Arthralgia

• Bronchitis

• Fever

• Chills

• Headache.

1. Eating a balanced diet low in saturated and trans fats.

2. Exercising regularly.

3. Maintaining a healthy weight.

4. Quitting smoking.

5. Do not stop your regular statin medications and continue following a proper diet, as Izirize Injection 1.5ml is only effective when combined with these therapies.

6. Do not discontinue this drug without the advice of a healthcare professional, even if symptoms improve.

7. Follow your doctor’s advice and routinely check your cholesterol levels to:

• Monitor the efficacy of Izirize Injection 1.5ml
• Allow timely adjustments to your treatment regimen if required.