9:["$","main",null,{"className":"py-10","children":[["$","$L18",null,{}],["$","section",null,{"className":"mx-auto max-w-7xl px-4 sm:px-6 lg:px-8","id":"","children":[[["$","$L19",null,{"hasCustomEntry":true,"customBreadcrumbEntry":[{"name":"Medicine","url":"/products"},{"name":"Jakavi 20mg Tablet","url":"#"}]}],["$","span",null,{"aria-hidden":"true","className":"w-px h-px block","style":{"marginLeft":"0.25rem","marginTop":"1rem"}}],[["$","$L1a",null,{"gutter":[48,24],"justify":"space-between","children":[["$","$L1b",null,{"lg":{"order":0,"span":7},"xs":{"order":1,"span":24},"children":[null,false,["$","div",null,{"className":"!sticky top-[140px] hidden md:block","children":["$","$L1c",null,{"content":[{"id":"bc31a561-0a1d-4729-8653-3992a9a8e3a4","type":"PAP","position":0,"content_placement":4,"data":{"heading":"Patient Assistance Programs","text":"$1d"}},{"id":"c0b27c67-7650-49d8-8e63-4c095d5e1de9","type":"PARA","position":1,"content_placement":1,"data":{"heading":"Introduction to Jakavi 20mg Tablet","text":"$1e"}},{"id":"cfd7f22d-595f-421d-97de-27fa6c8a06c1","type":"PARA","position":2,"content_placement":1,"data":{"heading":"Uses of Jakavi 20mg Tablet","text":"

Myelofibrosis
Polycythemia vera
Acute-graft-versus host disease
Chronic-graft-versus host disease

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Ruxolitinib, a kinase inhibitor, inhibits dysregulated Janus Associated Kinase (JAK) 1 and JAK2 signalling associated with myelofibrosis and polycythemia vera. By blocking certain enzymes, this medicine can reduce the serious risk of blood or vascular complications in myelofibrosis and polycythemia vera. In GvHD, it reduces the signs and symptoms, improving the disease and survival of transplanted cells.

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Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, and supplements and herbal products. Certain medications like fluconazole and other CYP3A4 inhibitors may interact with Jakavi 20mg tablet and reduce its effectiveness by causing undesirable side effects.

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Do not store this medicine above 30°C
Keep the medicine out of reach from children and pets
If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

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Your doctor will decide the dose and duration of Jakavi 20mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.

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Breastfeeding is not recommended in patients taking Jakavi 20mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment and for 2 weeks after the last dose.

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It is unknown whether consuming alcohol is safe when taking Jakavi 20mg tablet. Inform your physician if you are an alcoholic before starting the treatment.

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Jakavi 20mg tablet should be administered cautiously in patients with liver problems. Dose adjustments are necessary for patients with liver diseases. Inform your physician if you have any liver disorder before the treatment.

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It is unknown whether Jakavi 20mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

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Do not drive or operate heavy machinery if you feel dizzy after taking Jakavi 20mg tablet. Consult your doctor for more advice.

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Do not take Jakavi 20mg tablet if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment.

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Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

Low red and white blood cell counts
Low platelet counts
Dizziness, headache
Bruising
Diarrhea
Infections including viral infection
Swelling in the face and body
Fatigue or tiredness

Serious

Severe infections like hepatitis B
Anemia
Bleeding

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You should continue taking this tablet until your doctor says since, it is a long-term treatment. Do not stop taking Jakavi 20mg tablet or reduce its dose without consulting a physician. Inform your physician if you get any infection or symptoms of bleeding during the treatment. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Inform your doctor if you are a smoker or a past smoker.

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Can a patient with kidney problems take Jakavi 20mg tablet?

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Jakavi 20mg tablet should be cautiously taken if you have any kidney problems. Dose adjustments are necessary for patients with kidney diseases. Inform your doctor if you are on dialysis and have any kidney disorders.

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I have tuberculosis, and can I take Jakavi 20mg tablet?

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Inform your physician if you have active tuberculosis or a past medical history of tuberculosis before starting the treatment with Jakavi 20mg tablet.

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What foods should I have to avoid while taking Jakavi 20mg tablet?

","answer":"

Grapefruit or grapefruit juice should be avoided while taking Jakavi 20mg tablet. Unless your doctor suggests special diets, you can follow the normal diet.

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Does Jakavi 20mg tablet weaken the immune system?

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The medicine can suppress your immune system and increase your chances of getting infections. Take precautions to prevent illness and injury.

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What if I overdose or take two doses of Jakavi 20mg tablet?

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If you overdosed or took two doses of Jakavi 20mg tablet unknowingly, immediately inform your healthcare professional and seek medical advice.

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Molecule name: Ruxolitinib

Therapeutic class: Antineoplastics

Pharmacological class: Kinase inhibitors

Indications:

1. Myelofibrosis

2. Polycythemia vera

3. Acute-graft-versus host disease

4. Chronic-graft-versus host disease

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Highlights of prescribing information, Ruxolitinib [Revised on 2021 Sep] [cited 2023 Mar 10]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/202192s023lbl.pdf
Jakavi 5mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. www.medicines.org.uk. 2022 [cited 2023 Mar 10]. Available from: https://www.medicines.org.uk/emc/product/4298/pil
Stefanie Ajayi et al; Ruxolitinib; Recent Results in Cancer Research; Published on 2018; Accessed on 13/03/2023; https://pubmed.ncbi.nlm.nih.gov/30069628/

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