JAKAVI 20MG TABLET

Introduction:

Jakavi 20mg Tablet is a targeted therapy containing the active constituent ruxolitinib. It is used to treat myelofibrosis, a rare blood cancer. Myelofibrosis is a disorder of bone marrow in which marrow is replaced by scarring tissue, resulting in a lack of normal blood cells and the spleen becomes significantly enlarged.

Jakavi 20mg Tablet is also used to treat polycythemia vera in people who were not able to be treated successfully with an anticancer medication, hydroxyurea. Polycythemia is a bone marrow disorder in which marrow produces too many blood cells resulting in thicker blood and reduced spleen size. 

This medication is not recommended for adolescents and children under the age of 18. Do not drink grapefruit juice while taking this medicine; it can affect the amount of medicine in your blood. Before taking Jakavi 20mg Tablet, talk to your physician if you have any infections, kidney disorders, liver disorders, tuberculosis, or skin cancer.

Jakavi 20 mg uses:

• Myelofibrosis
• Polycythemia vera

How Jakavi 20mg Tablet works:

Jakavi 20mg Tablet 14'S prevents the abnormal growth and multiplication of blood cells by blocking the enzymes JAK1 and JAK2 (Janus Associated Kinases).

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Jakavi 20mg Tablet out of sight and reach of children.
• Do not store above 30°C.

References:

1. Novartis Europharm Limited, Electronic medicines compendium (emc), [Revised on Dec 2020] [ Accessed on 30th Nov 2021], https://www.medicines.org.uk/emc/files/pil.4298.pdf
2. DSM Pharmaceuticals, Inc, US Food and Drug Administration, [Revised on Nov 2011] [ Accessed on 30th Nov 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202192lbl.pdf
3. Heiko Becker et al; Ruxolitinib; Recent Results in Cancer Research; Published on 2014; Accessed on 30/11/2021; https://pubmed.ncbi.nlm.nih.gov/24756798/
4. Stefanie Ajayi et al; Ruxolitinib; Recent Results in Cancer Research; Published on 2018; Accessed on 30/11/2021; https://pubmed.ncbi.nlm.nih.gov/30069628/

How to use Jakavi 20mg Tablet:

Follow the exact dosage prescribed by your doctor. Swallow the tablets whole without crushing. Do not drink grapefruit juice while taking this medicine.

Safety advice:

Pregnancy:

Jakavi 20mg Tablet is not recommended for pregnant women. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine. 

Breastfeeding:

Jakavi 20 mg is not recommended for breastfeeding women. You need to tell your physician if you are breastfeeding before taking this medicine. 

Liver:

You need to tell your physician if you have any liver disorders before taking Jakavi 20mg Tablet. 

Kidney:

You need to tell your physician if you have any kidney disorders before taking Jakavi 20mg Tablet. 

Driving: 

Jakavi 20mg Tablet can cause dizziness. Avoid driving if you are unwell.

Others:

• Talk to your doctor if you have or ever had skin cancer, tuberculosis, or have any infections before taking Jakavi 20mg Tablet.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. The Jakavi 20 mg side effects are:

Serious:

• Bleeding in the brain, stomach, or intestine
• Skin rash with blisters
• Low blood cell count
• Fever, chills, or infections

Common:

• High cholesterol levels
• Headache, dizziness
• Weight gain
• High blood pressure
• Difficulty in breathing, pain in the chest
• Constipation
• Flatulence