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Jakavi 5mg Tablet
Last updated on 31 Mar 2026 | 09:31 AM (IST)
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MRP: ₹24345
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Jakavi 5 mg Tablet is a prescription medicine used to treat certain blood disorders, including myelofibrosis and polycythemia vera. It contains ruxolitinib, a targeted therapy that works by inhibiting Janus kinase (JAK) pathways involved in abnormal blood cell production and inflammation. Jakavi is used under strict medical supervision as part of a specialised hematology treatment plan.
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Introduction
Jakavi 5mg Tablet contains the active ingredient Ruxolitinib and belongs to the class of kinase inhibitors. It is an advanced anticancer medication used to treat myelofibrosis, a rare bone marrow cancer that disrupts normal blood cell production. It is also prescribed for polycythemia vera, a condition where the body produces too many red blood cells, particularly in patients who do not respond well to hydroxyurea. Additionally, Jakavi 5mg tablet for GVHD (Graft versus Host Disease) is approved for adults and children aged 12 and above who have not responded adequately to steroid or systemic therapies.
The Jakavi 5mg for myelofibrosis dosage is determined by the physician based on body weight, blood counts, and treatment response. It works by blocking abnormal signalling pathways that drive excessive cell growth, helping to reduce symptoms like spleen enlargement and fatigue.
Patients should avoid this medication if allergic to Ruxolitinib or any of its components. Inform your doctor beforehand if you have a history of tuberculosis, hepatitis B or C, liver or kidney disease, or low blood cell counts. Common side effects include dizziness, headache, swelling, bruising, and reduced platelet levels. Notify your doctor immediately if you experience persistent bleeding or infection.
For affordability, the Jakavi 5mg Tablet price and Ruxolitinib 5mg tablet price in India may vary by pharmacy or region. Patients can buy Jakavi 5mg Tablet online from trusted sources to ensure authenticity. The Novartis Jakavi 5mg price reflects its high-quality manufacturing standards. If unavailable, your doctor may suggest a Jakavi 5mg substitute such as Ruxolix, though Jakavi 5mg vs Ruxolix 5mg comparisons show both have similar efficacy and composition.
Eligible patients can also explore the Jakavi 5mg Patient Assistance Program, which provides financial support to make treatment more accessible. Overall, Jakavi remains a trusted option in modern haematology for managing complex blood and bone marrow disorders.
Uses
Jakavi 5mg uses are
Myelofibrosis
Polycythemia vera
Acute-graft-versus-host disease
Chronic-graft-versus-host disease
How Jakavi 5mg Tablet works
Ruxolitinib, a kinase inhibitor, inhibits dysregulated Janus Associated Kinase (JAK) 1 and JAK2 signaling associated with myelofibrosis and polycythemia vera. By blocking certain enzymes, this medicine can reduce the serious risk of blood or vascular complications in myelofibrosis and polycythemia vera. In GvHD, it reduces the signs and symptoms, improving the disease and survival of transplanted cells.
Interaction of Jakavi 5mg Tablet with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, and supplements and herbal products. Certain medications like fluconazole and other CYP3A4 inhibitors may interact with Jakavi 5mg tablet and reduce its effectiveness by causing undesirable side effects.
Storage conditions
Do not store this medicine above 30°C
Keep the medicine out of reach from children and pets
If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
How to take Jakavi 5mg Tablet
Your doctor will decide the dose and duration of Jakavi 5mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Safety Advice for Jakavi 5mg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking Jakavi 5mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment and for 2 weeks after the last dose.
Alcohol
It is unknown whether consuming alcohol is safe when taking Jakavi 5mg tablet. Inform your physician if you are an alcoholic before starting the treatment.
Liver
Jakavi 5mg tablet should be administered cautiously in patients with liver problems. Dose adjustments are necessary for patients with liver diseases. Inform your physician if you have any liver disorder before the treatment.
Lungs
It is unknown whether Jakavi 5mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Do not drive or operate heavy machinery if you feel dizzy after taking Jakavi 5mg tablet. Consult your doctor for more advice.
Pregnancy
Do not take Jakavi 5mg tablet if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Jakavi 5mg side effects are
Common
Low red and white blood cell counts
Low platelet counts
Dizziness, headache
Bruising
Diarrhea
Infections, including viral infections
Swelling in the face and body
Fatigue or tiredness
Serious
Severe infections like hepatitis B
Anemia
Bleeding
Expert tips
Continue the medication exactly as prescribed. It is a long-term treatment and should not be stopped abruptly.
Do not reduce or discontinue Jakavi 5mg Tablets without consulting your doctor.
Inform your physician immediately if you notice any signs of infection or bleeding during treatment.
This medicine can increase your risk of bleeding, bruising, or getting infections more easily, so take extra precautions to avoid injuries or exposure to illness.
Maintain good hygiene, and wash your hands frequently to reduce the risk of infections.
Your doctor will perform regular laboratory tests to monitor how the medicine affects your blood and overall health.
Inform your doctor if you are currently a smoker or a former smoker, as it may influence your treatment plan or response to the medicine.
FAQs about Jakavi 5mg Tablet
Q1.
Can a patient with kidney problems take Jakavi 5mg tablet?
Jakavi 5mg tablet should be cautiously taken if you have any kidney problems. Dose adjustments are necessary for patients with kidney diseases. Inform your doctor if you are on dialysis and have any kidney disorders.
Q2.
I have tuberculosis, and can I take Jakavi 5mg tablet?
Inform your physician if you have active tuberculosis or a past medical history of tuberculosis before starting the treatment with Jakavi 5mg tablet.
Q3.
What foods should I have to avoid while taking Jakavi 5mg tablet?
Grapefruit or grapefruit juice should be avoided while taking Jakavi 5mg tablet. Unless your doctor suggests special diets, you can follow the normal diet.
Q4.
Does Jakavi 5mg tablet weaken the immune system?
The medicine can suppress your immune system and increase your chances of getting infections. Take precautions to prevent illness and injury.
Q5.
What if I overdose or take two doses of Jakavi 5mg tablet?
If you overdosed or took two doses of Jakavi 5mg tablet unknowingly, immediately inform your healthcare professional and seek medical advice.
Fact Box
Molecule name
| Ruxolitinib |
Therapeutic class | Antineoplastics |
Pharmacological class | Janus kinase inhibitor |
Indications | 1. Myelofibrosis 2. Polycythemia vera 3. Acute-graft-versus host disease 4. Chronic-graft-versus host disease |
References
- Highlights of prescribing information, Ruxolitinib [Revised on 2021 Sep] [cited 2023 Mar 10]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/202192s023lbl.pdf
- Jakavi 5mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. www.medicines.org.uk. 2022 [cited 2023 Mar 10]. Available from: https://www.medicines.org.uk/emc/product/4298/pil
- Stefanie Ajayi et al; Ruxolitinib; Recent Results in Cancer Research; Published on 2018; Accessed on 13/03/2023; https://pubmed.ncbi.nlm.nih.gov/30069628/
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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