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Kyzific 40mg Tablet
Last updated on 26 Sep 2026 | 08:41 AM (IST)
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Kyzific 40 mg Tablet is a prescription medicine used to treat certain types of Philadelphia chromosome-positive chronic myeloid leukaemia (Ph+ CML) in adults. It contains Asciminib, which helps slow the growth of abnormal leukaemia cells. It should be taken only as prescribed by your doctor and requires regular monitoring during treatment.
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Introduction to Kyzific 40mg Tablet
Kyzific 40mg tablet contains the active substance Asciminib. It is an anticancer medicine that belongs to the class tyrosine kinase receptor inhibitors.
Kyzific 40mg tablet is used to treat a certain type of chronic myeloid leukaemia (CML; a type of cancer of the white blood cells) in a chronic phase (CP) who have been previously treated with two or more tyrosine kinase inhibitors. It works by inhibiting the BCR-ABL1 tyrosine kinase, a fusion protein resulting from the Philadelphia chromosome translocation in chronic myeloid leukaemia (CML). It binds specifically to the myristoyl pocket of the ABL1 domain within the BCR-ABL1 protein, inducing a conformational change that locks the protein in an inactive state and inhibits its oncogenic activity.
Inform your doctor before starting treatment with Kyzific 40mg tablet, as it may cause blood problems such as low platelet and white blood cell counts, pancreatic issues, and high blood pressure. Make sure to inform your physician of all the medicines you are taking before you start the treatment with this medication. Report any symptoms of difficulty breathing together with a cough or fever, chest pain, fever, weakness, or seizures.
Uses of Kyzific 40mg Tablet
- To treat a certain type of chronic myeloid leukaemia (CML; a type of cancer of the white blood cells) in a chronic phase (CP) who have been previously treated with two or more tyrosine kinase inhibitors.
Therapeutic Effects of Kyzific 40mg Tablet
Kyzific works by binding specifically to the myristoyl pocket of the ABL1 domain within the BCR-ABL1 protein, inducing a conformational change that locks the protein in an inactive state and inhibits its oncogenic activity.
Interaction of Kyzific 40mg Tablet with other drugs
Inform your healthcare professional about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products.
Certain medications interacting with Kyzific 40 mg may reduce effectiveness by causing undesirable side effects.
More Information about Kyzific 40mg Tablet
- Store Kyzific 40mg tablet at room temperature between 20°C to 25°C.
- Keep out of sight and reach of children and pets.
- Store in the original container.
- Keep it away from moisture, heat and direct sunlight.
- Complete blood counts should be performed every two weeks for the first three months of treatment and monthly after that or as clinically indicated. Patients should be monitored for signs and symptoms of myelosuppression.
How to consume Kyzific 40mg Tablet
Take Kyzific 40mg tablet exactly as your doctor tells you. Do not change your dose or schedule or stop taking Kyzific 40mg tablet unless your healthcare provider tells you to. Take Kyzific 40mg tablet without food.
You should avoid eating for at least 2 hours before and 1 hour after taking the Kyzific 40mg tablet. Swallow Kyzific 40mg tablets whole. Do not break, crush, or chew tablets.
Safety Advice for Kyzific 40mg Tablet
Breast Feeding
Don’t breastfeed while taking kyzific 40mg tablet and for 1 week after your last dose because the drug may come through into your breast milk.
Alcohol
It is not known whether it is safe to use kyzific 40mg Tablet while consuming alcohol. Consult the doctor before taking this medication.
Liver
You need to tell your doctor if you have any liver disorders before taking kyzific 40mg tablet. Your doctor may decide to adjust the dose or delay treating you depending on your liver function.
Lungs
Before starting treatment with Kyzific 40mg tablet, talk to your doctor if you have any lung conditions.
Driving
kyzific 40mg Tablet is not likely to affect driving and the use of any tools or machines. Consult the doctor before taking this medication.
Pregnancy
Kyzific 40mg tablet is not safe for use during pregnancy because it can harm the developing baby.
Side Effects of Kyzific 40mg Tablet
Like all medications, Kyzific 40 mg tablet can cause side effects, although not everyone who takes it will experience them.
Common
- Upper respiratory tract infection
- Headache and nausea
- Tiredness
- Rashes
- Muscle, bone or joint pain
- Diarrhea
Rare
- Trouble breathing or swallowing
- Swelling of the face, lips, or tongue
- Fever
- Skin rash or flushing of your skin
- Fast heartbeat
- Severe Pancreatitis
Word of Advice
If you are taking any laboratory tests, tell your doctor that you are taking Kyzific 40 mg tablet. It may cause changes in test results or affect the interpretation of certain lab findings.
It may also increase your blood pressure. You may be asked to monitor your blood pressure frequently while taking this medication. Please let your doctor know if you notice any changes in your blood pressure.
FAQs about Kyzific 40mg Tablet
Q1.
Is kyzific 40 mg tablet a chemo drug?
Kyzific 40 mg tablet is Tyrosine kinase inhibitors (TKIs) that is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (Ph+ CML) as a targeted therapy drug.
Q2.
Does kyzific 40 mg tablet cause weight gain?
kyzific 40 mg tablet does not cause weight gain. However, any medicine can have different types of adverse effects, and individual reactions may differ. If you are gaining weight unexpectedly while taking Kyzific 40mg tablet, consult a healthcare professional to establish if it is due to the medicine or another underlying condition.
Q3.
What is the half-life of Kyzific 40mg tablet?
The terminal elimination half-life of kyzific 40 mg tablets is 5.5 hours when administered at 40mg twice daily and 9 hours when administered at 200mg twice daily.
Q4.
Is kyzific 40 tablet a TKI?
Kyzific 40 mg tablet is a novel Tyrosine kinase inhibitors (TKIs) that are used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (Ph+ CML).
Q5.
What is the latest drug for CML?
Kyzific 40 mg tablet is the latest drug approved to treat CML approved by the Food and Drug Administration (FDA) approved kyzific 40 tablets in October 2021.
Fact Box of Kyzific 40mg Tablet
| Molecule name | Asciminib
|
| Pharmacological class | BCR-ABL1 tyrosine kinase inhibitor |
Therapeutic class | tyrosine kinase inhibitors |
| Indications | To treat a certain type of chronic myeloid leukaemia in a chronic phase (CP) |
References
Disclaimer
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Author Details
Written By
Dr. Deva Prasath S.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)
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