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Salt Composition : Letrozole


Origin of Medicine : India

MRP: ‚āĻ79
Price : ‚āĻ48
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Introduction to Letero 2.5mg Tablet

Letero 2.5mg is an anti-cancer drug that belongs to the class aromatase inhibitor. It is indicated as a supportive therapy after the main therapy or first-line therapy for postmenopausal women with early and advanced breast cancer whose tumors are hormone receptor-positive. Since high amounts of estrogen are found to trigger breast cancer, this medicine reduces the levels of the female reproductive hormone by blocking the enzyme (aromatase) that is involved in the production of estrogen. This medicine aims to slow or stop the growth and/or spreading to other body parts. 

Inform your physician if you have not attained menopause yet, as this medicine does not work for premenopausal women. Since this medicine tends to reduce the levels of female reproductive hormones, it is not advised for menstruating women as it is related to causing fertility issues. It is advised to keep track of your cholesterol levels as this medicine tends to elevate cholesterol levels. This medicine could also decrease bone mineral density. Hence, discuss with your physician and consider monitoring your bone parameters regularly. It is advised to use effective birth control during the treatment and at least 3 weeks after the last dose because Letero 2.5mg can cause when it is administrated.

Uses of Letero 2.5mg Tablet

  • First and second-line treatment of postmenopausal women with hormone receptor-positive breast cancer.
  • Supportive to standard treatment for postmenopausal women with early breast cancer.
  • Treatment for unknown advanced breast cancer in postmenopausal women.
  • Extended supportive therapy for postmenopausal women with early breast cancer who have already taken other anti-cancer medication.

Therapeutic Effects of Letero 2.5mg Tablet

The growth of some cancers of breasts are stimulated by estrogens. Letero 2.5mg Tablet is a nonsteroidal compound that inhibits estrogen production by blocking the enzyme aromatase. This medicine reduces the tumor size and stops or slows the progression of the disease, avoiding the reoccurring of early-stage breast cancer and improving the survival rate.

Interaction of Letero 2.5mg Tablet with other drugs

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, or herbal products you take or have taken before the treatment. Certain medications like tamoxifen and others may interact with Letero 2.5mg and cause undesirable side effects. 

More Information about Letero 2.5mg Tablet

  • Keep the tablets away from the reach of children and pets.
  • Store Letero¬†2.5mg Tablets at an optimal temperature not exceeding 25¬įC.

How to consume Letero 2.5mg Tablet

It is advised to consume Letrozole Tablets exactly as your doctor prescribes. It can be consumed with or without food and should be swallowed with a glass of water. Letero 2.5mg can be taken with or without food. It is better to take the tablet at a fixed time. Do not break, chew or crush the tablet. 

Safety Advices for Letero 2.5mg Tablet

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Letero 2.5mg tablets are highly unsafe during pregnancy because they may cause harm to the unborn baby. It is better to discuss with a doctor to use of an effective contraceptive method during the letrozole treatment if you still have the potential to become pregnant. It is recommended to consult your physician if you are pregnant already or suspect pregnancy.  

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Breast Feeding


It is not safe to breastfeed your baby when you are taking Letero 2.5mg tablet Tablet. It is advised to avoid breastfeeding for at least three weeks after the last dose of the medicine.

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Inform your physician if you have liver disease, as the Letero 2.5mg tablet is not recommended for patients with severe liver disease. Dose adjustment may be required.

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Certain lung diseases can occur while using Letero 2.5mg tablet. Consult your doctor if you have lung diseases. 

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It is not recommended to consume alcohol while you are on the treatment with Letero 2.5mg tablet as it may cause serious complications.

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Caution is required while driving and operating machinery when you take Letero 2.5mg tablet causes dizziness, sleepiness, and tiredness.

Side Effects of Letero 2.5mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


  • Decreased red blood cells
  • Decreased bone mineral density
  • Fluid build up in lungs


  • Swelling in the face, eyes, feet, and legs
  • Hot sweats and excessive sweating
  • Hypercholesterolemia (high cholesterol)
  • Constipation
  • Heart papilation
  • Hypertension
  • Diarrhea
  • Loss of appetite
  • Nausea and Vomiting
  • Muscle pain, bone pain, and joint stiffness
  • Dizziness, tiredness, and sleepiness
  • Breathing difficulty
  • Arthralgia

Word of Advice

Notify your doctor if you have hypersensitivity because this medication is contraindicated to such a medical condition. Inform your physician if you have osteoporosis or bone fractures, and periodic monitoring of bone mineral density is required while you are on Letero 2.5mg tablet because this medicine can cause a decrease in bone mineral density. Discuss with your doctor if you are planning for pregnancy, as this medicine shall impact the reproductive potential and might lead to fertility issues. Do not consume this medicine if you are still menstruating and have not yet gone through menopause. Report to your doctor if you are tolerant of any sugar, as Letrozole Tablet contains lactose ingredients. If you missed a dose, do not take a double dose for the forgotten dose. Skip the missed dose and go with a regular schedule.


Q 1. How does Letero 2.5mg tablet work?

Letero 2.5mg tablet is an anti-estrogen medication. It reduces estrogen levels in your body by inhibiting the enzyme aromatase, which is responsible for estrogen production. Estrogen stimulates the growth of certain types of breast cancer in your body. Reduced estrogen production may prevent cancer from spreading.

Q 2. Can Letero 2.5mg cause mood changes?

Mood changes, such as depression or anxiety, are not common side effects of Letero 2.5mg. However, if you experience any changes in mood while taking Letero 2.5mg, it's important to talk to your doctor.

Q 3. What are the serious side effects of the Letero 2.5mg tablet?

The serious side effects do not occur in everyone; very few people experience them. The serious side effects of the Letero 2.5mg tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis, and fluid build-up in the lungs.

Q 4. Is it better to take Letero 2.5mg in the morning or at night?

You can take Letero 2.5mg in the morning, midday, or evening with or without food, but you should take it at about the same time each day.

Q 5. How often should I have my bone density checked while taking Letero 2.5mg ?

Letero 2.5mg can increase the risk of bone fractures in some people, so it's important to have regular bone density checks while taking the medication. Your doctor will recommend how often you should have these checks.

Q 6. How long is Letero 2.5mg taken?

The length of time a person takes Letero 2.5mg depends on their individual situation and the recommendation of their doctor. Treatment may last for several years.

Fact Box of Letero 2.5mg Tablet

Molecule name: Letrozole 

Therapeutic class: Aromatase Inhibitor

Pharmacological class: Anti-Neoplastic drug

Indications: Treatment for early breast cancer in postmenopausal women


  1. Cipla (EU) Limited, Electronic Medicines Compendium (EMC), [Revised on Oct 2021], [Accessed on 22th Mar 2023],
  2. Novartis Pharmaceuticals Corporation, [Revised on May 2020], [Accessed on 22th Mar 2023],
  3. HIGHLIGHTS OF PRESCRIBING INFORMATION. (n.d.). [online] Available at: [Accessed on 22th Mar 2023].
  4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  5. KD Tripathi, Estrogens, Progestins and Contraceptives, Essentials of Medical Pharmacology, 8th Edition, 2019, 330-353.


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